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Protecting the Health of Future Generations: Assessing and Preventing Exposures to Endocrine-Disrupting Flame Retardant Chemicals & PCBs in Two Alaska Native Arctic Communities on St. Lawrence Island

Award Number: R01ES019620
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Protecting the Health of Future Generations: Assessing and Preventing Exposures to Endocrine-Disrupting Flame Retardant Chemicals & PCBs in Two Alaska Native Arctic Communities on St. Lawrence Island - Project Summary/Abstract The objectives of this community-based participatory research (CBPR) project are to investigate exposures, endocrine effects, and mechanisms of developmental disruption associated with legacy contaminants and emerging flame retardant chemicals in two Yupik communities on St. Lawrence Island (SLI) in arctic Alaska. The Arctic is subject to atmospheric deposition of globally-distilled persistent organic pollutants (POPs), acting as a hemispheric sink for POPs that are transported from lower latitudes. Thus, the Arctic is significant as an indicator region and contains some of the most highly contaminated animals and people in the world. This study addresses a primary public health concern of the people of SLI by focusing on the levels and effects of legacy and emerging contaminants on the development of children in an arctic indigenous population that is vulnerable, underserved, and experiences significant health disparities. Other studies have shown that young children are more highly exposed than adults. Using innovative and minimally invasive techniques, we will assess exposures of children to polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and emerging halogenated and non-halogenated organophosphate flame retardants. We will quantify PCBs and flame retardant chemicals in household dust, known to be an important exposure route. We will assess relationships among contaminant levels and evidence of health disruption via transcriptomics and endocrinology. We will use chemical concentrations in household dust and utilization of a subsistence diet as determined by stable isotope analysis to assess exposure pathways of these compounds. In order to understand the mechanistic basis of developmental disruption, and to have a reference for interpretation of human data, we will monitor patterns of gene expression, endocrinology, and histology of our resident fish model, the stickleback, from both contaminated and reference sites. Collectively, we will increase our understanding of routes of exposure, endocrine disruption, and effects on the transcriptome of Yupik children exposed to high levels of PCBs and flame retardant chemicals. This study provides an opportunity to investigate the levels of PBDEs and emerging flame retardants in nails and blood in relation to health outcomes of arctic indigenous children for the first time. Our CBPR project will also empower SLI communities with the knowledge and tools they need to address important health disparities in their communities. Our results will inform public health interventions and improve health outcomes of arctic children broadly. Furthermore, discovery of bioindicators relevant to early detection of developmental disruption will enable early intervention and improve health outcomes. Importantly, we will build capacity through our CBPR approach, public health interventions, and policy outreach, which will mitigate future exposure of SLI children to toxic chemicals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	ALASKA COMMUNITY ACTION ON TOXICS	1225 E INTL AIRPORT RD STE 220	ANCHORAGE	AK	99518	ANCHORAGE	USA	Environmental Health	000	10	8/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	ALASKA COMMUNITY ACTION ON TOXICS	1225 E INTL AIRPORT RD STE 220	ANCHORAGE	AK	99518	ANCHORAGE	USA	Environmental Health	000	10	7/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $544,266 )
2021	2021	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	10	7/13/2021	NON-COMPETING CONTINUATION	$544,266
														Subtotal = $544,266

Issue Date FY: 2020 ( Subtotal = $564,715 )
2020	2020	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	9	7/1/2020	NON-COMPETING CONTINUATION	$564,715
														Subtotal = $564,715

Issue Date FY: 2019 ( Subtotal = $579,553 )
2019	2019	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	8	7/2/2019	NON-COMPETING CONTINUATION	$562,796
2019	2019	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	003	8	8/20/2019	NON-COMPETING CONTINUATION	$3,791
2019	2018	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	002	7	8/19/2019	NON-COMPETING CONTINUATION	$5,744
2019	2017	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	001	6	8/16/2019	COMPETING CONTINUATION	$7,222
														Subtotal = $579,553

Issue Date FY: 2018 ( Subtotal = $612,264 )
2018	2018	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	002	7	7/9/2018	NON-COMPETING CONTINUATION	$552,266
2018	2015	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	001	5	6/14/2018	SUPPLEMENT FOR EXPANSION	$28,000
2018	2015	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	5	6/14/2018	NON-COMPETING CONTINUATION	$31,998
														Subtotal = $612,264

Issue Date FY: 2017 ( Subtotal = $494,466 )
2017	2017	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	002	6	8/28/2017	COMPETING CONTINUATION	$554,464
2017	2015	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	5	8/1/2017	NON-COMPETING CONTINUATION	-$31,998
2017	2015	ALASKA COMMUNITY ACTION ON TOXICS	505 W NORTHERN LIGHTS BLVD STE 205	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	001	5	8/1/2017	SUPPLEMENT FOR EXPANSION	-$28,000
														Subtotal = $494,466

Issue Date FY: 2016 ( Subtotal = $96,523 )
2016	2016	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	5	6/28/2016	SUPPLEMENT FOR EXPANSION	$96,523
														Subtotal = $96,523

Issue Date FY: 2015 ( Subtotal = $521,629 )
2015	2015	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	5	2/11/2015	NON-COMPETING CONTINUATION	$493,629
2015	2015	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	001	5	5/1/2015	SUPPLEMENT FOR EXPANSION	$28,000
														Subtotal = $521,629

Issue Date FY: 2014 ( Subtotal = $459,072 )
2014	2014	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	4	4/4/2014	NON-COMPETING CONTINUATION	$459,072
														Subtotal = $459,072

Issue Date FY: 2013 ( Subtotal = $456,745 )
2013	2013	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	001	3	7/9/2013	NON-COMPETING CONTINUATION	$37,286
2013	2013	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	3	3/26/2013	NON-COMPETING CONTINUATION	$419,459
														Subtotal = $456,745

Issue Date FY: 2012 ( Subtotal = $468,068 )
2012	2012	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	001	2	4/29/2012	NON-COMPETING CONTINUATION	$469,386
2012	2011	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	1	2/8/2012	NEW	-$1,318
														Subtotal = $468,068

Issue Date FY: 2011 ( Subtotal = $471,521 )
2011	2011	ALASKA COMMUNITY ACTION ON TOXICS	505 WEST NORTHERN LIGHTS BLVD	ANCHORAGE	AK	99503	ANCHORAGE	USA	Environmental Health	000	1	8/8/2011	NEW	$471,521
														Subtotal = $471,521

Grand Total All Awards = $5,268,822

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Protecting the Health of Future Generations: Assessing and Preventing Exposures to Endocrine-Disrupting Flame Retardant Chemicals & PCBs in Two Alaska Native Arctic Communities on St. Lawrence Island

Award Number: R01ES019620

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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