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The CHARGE Study: Childhood Autism Risks from Genetics and the Environment

Award Number: R01ES015359
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2009
PERIOD OF PERFORMANCE END DATE: 09/24/2012

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The CHARGE Study: Childhood Autism Risks from Genetics and the Environment - Abstract Few rigorous epidemiologic studies have addressed the environmental causes and biologic underpinnings of autism spectrum disorder (ASD). The CHARGE (CHildhood Autism Risks from Genetics and Environment) Study is a large, population-based case-control investigation of environmental risk factors, broadly defined, in relation to ASD and developmental delay without ASD symptoms, with referents from the general population. Fieldwork began In 2003, and by now CHARGE has published widely on exposures such as air pollution, mercury, flame retardants, maternal nutritional status in the peri-conception, untreated fever during pregnancy, mitochondrial dysfunction, candidate genes, a wide array of functional immune markers in both the child and the mother, and maternal metabolic conditions including obesity and diabetes. This last finding is notable, given the epidemic of obesity and type 2 diabetes that has occurred in parallel with the steady rise in ASD over the last few decades. Moreover, an emerging literature implicates several endocrine disrupting chemicals as contributing to obesity and metabolic dysregulation, including hyperinsulinemia, and to neurodevelopmental disorders as well. This project therefore builds upon these observations in several ways. First, obesity and type 2 or gestational diabetes will be examined in a larger sample, and glucose challenge test (GCT) results for the first time, to determine associations not only with development of ASD and intellectual impairment in the children, but also with specific speech and language delays, behavioral phenotypes such as attention deficits or hyperactivity, and gene expression. Second, these maternal metabolic conditions will be evaluated for associations with markers of both metabolic and immune dysregulation to be measured in neonatal bloodspots. Third, the predictive value of neonatal bloodspot markers for a later diagnosis of ASD or other child developmental and behavioral outcomes will be assessed. Fourth, the maternal metabolic conditions will be analyzed for potential links with upstream exposures to phthalates and anti- bacterial compounds, ubiquitous chemicals in common household products. Finally, this project will examine how gene variants that play a role in biochemical pathways relevant to the processes under study may influence susceptibility of the mother, the neonate or the child. To ensure adequate power for this analysis of gene-environment interaction, the sample size will be increased to 2400 children. This project addresses several goals set by the NIH Interagency Autism Coordinating Committee: 1) to discover environmental factors contributing to ASD, particularly in the prenatal period, 2) to understand biological mechanisms for ASD risk, including gene-by-environment interactions, and 3) to identify children at risk for ASD at earlier time points. Results of this detailed inquiry into early exposures, maternal pathophysiology and prognostic markers in the newborn will set the stage for developing prevention strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$8 )
2022	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	10	12/7/2021	SUPPLEMENT FOR EXPANSION	-$8
2022	2009	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Recovery Act Research Support	000	3	12/7/2021	SUPPLEMENT FOR EXPANSION	$8
2022	2009	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Trans-NIH Recovery Act Research Support	002	3	1/12/2022	SUPPLEMENT FOR EXPANSION	-$8
														Subtotal = -$8

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	10	6/25/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	10	6/25/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	10	6/25/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $235,500 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	10	9/17/2019	SUPPLEMENT FOR EXPANSION	$235,500
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	10	6/17/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	10	6/17/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $235,500

Issue Date FY: 2018 ( Subtotal = $514,654 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	10	9/13/2018	SUPPLEMENT FOR EXPANSION	$514,654
														Subtotal = $514,654

Issue Date FY: 2017 ( Subtotal = $1,125,781 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	008	10	8/18/2017	NON-COMPETING CONTINUATION	$1,125,781
2017	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	007	9	4/21/2017	EXTENSION WITH OR WITHOUT FUNDS	$82,158
2017	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	006	9	4/21/2017	EXTENSION WITH OR WITHOUT FUNDS	$56,116
2017	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	004	9	4/21/2017	EXTENSION WITH OR WITHOUT FUNDS	-$56,116
2017	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	005	9	4/21/2017	EXTENSION WITH OR WITHOUT FUNDS	-$82,158
2017	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	9	2/9/2017	EXTENSION WITH OR WITHOUT FUNDS	$142,387
2017	2015	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	003	8	2/9/2017	SUPPLEMENT FOR EXPANSION	-$82,158
2017	2015	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	8	2/9/2017	NON-COMPETING CONTINUATION	-$4,113
2017	2015	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	002	8	2/9/2017	SUPPLEMENT FOR EXPANSION	-$56,116
														Subtotal = $1,125,781

Issue Date FY: 2016 ( Subtotal = $1,225,233 )
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	9	6/29/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,225,233
														Subtotal = $1,225,233

Issue Date FY: 2015 ( Subtotal = $1,244,326 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	8	6/17/2015	NON-COMPETING CONTINUATION	$1,106,052
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	002	8	6/24/2015	SUPPLEMENT FOR EXPANSION	$82,158
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	8	6/23/2015	SUPPLEMENT FOR EXPANSION	$56,116
														Subtotal = $1,244,326

Issue Date FY: 2014 ( Subtotal = $1,327,498 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	7	7/21/2014	NON-COMPETING CONTINUATION	$1,114,894
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	7	9/17/2014	SUPPLEMENT FOR EXPANSION	$212,604
														Subtotal = $1,327,498

Issue Date FY: 2013 ( Subtotal = $1,151,250 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	003	6	8/19/2013	COMPETING CONTINUATION	$1,151,250
2013	2012	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	002	5	8/14/2013	SUPPLEMENT FOR EXPANSION	$0
2013	2011	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	5	8/14/2013	NON-COMPETING CONTINUATION	$0
2013	2011	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	5	4/2/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,151,250

Issue Date FY: 2012 ( Subtotal = $188,012 )
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	5	8/6/2012	SUPPLEMENT FOR EXPANSION	$188,012
														Subtotal = $188,012

Issue Date FY: 2011 ( Subtotal = $965,562 )
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	001	5	6/10/2011	NON-COMPETING CONTINUATION	$60,347
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	5	1/25/2011	NON-COMPETING CONTINUATION	$905,215
														Subtotal = $965,562

Issue Date FY: 2010 ( Subtotal = $1,005,627 )
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	4	1/29/2010	NON-COMPETING CONTINUATION	$1,005,627
														Subtotal = $1,005,627

Issue Date FY: 2009 ( Subtotal = $2,633,513 )
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	3	2/5/2009	NON-COMPETING CONTINUATION	$913,519
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Trans-NIH Recovery Act Research Support	002	3	9/24/2009	SUPPLEMENT FOR EXPANSION	$1,212,792
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Trans-NIH Recovery Act Research Support	003	3	9/1/2009	SUPPLEMENT FOR EXPANSION	$405,700
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	001	3	3/20/2009	NON-COMPETING CONTINUATION	$101,502
														Subtotal = $2,633,513

Grand Total All Awards = $13,763,073

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The CHARGE Study: Childhood Autism Risks from Genetics and the Environment

Award Number: R01ES015359

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2009

PERIOD OF PERFORMANCE END DATE: 09/24/2012

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