Thursday, November 21, 2024 11/21/2024

Diversity Supplement to Molecular and Cellular Basis of PCB Developmental Neurotoxicity (Mendieta)

Award Number: R01ES014901
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Lower-chlorinated polychlorinated biphenyls (LC-PCBs) are increasingly recognized as a significant risk to human health, and a primary target of concern is the developing brain. LC-PCBs are the predominant PCB congener type detected in the serum of pregnant women at increased risk of having a child with a neurodevelopmental disorder (NDD), and they are widely detected in not only school air but also the serum of schoolchildren and teachers. The parent grant investigates how CYP-mediated metabolism influences the in vitro and in vivo effects of LC-PCBs on CREB-dependent neurodevelopmental processes using state-of-the-art mouse models that express human CYP2A6 or CYP2B6 but not mouse Cyp2a, 2b, 2f2, 2g1, and 2s1 proteins (Cyp2abfgs-null mice). Preliminary data generated under the parent grant suggests that the LC-PCB, PCB 28, interferes with axonal and dendritic growth in primary rat cortical neuron-glia co-cultures. This diversity supplement leverages and extends findings from the parent grant to address the following questions: (1) Does exposure to PCB 28 cause developmental neurotoxicity (DNT) in vivo, and (2) To what extent does the route of exposure influence the in vivo DNT of PCB 28, e.g., are different neurotoxic outcomes observed in pups born to dams exposed to PCB 28 via diet vs. inhalation? To address these questions, the diversity supplement will use Sprague Dawley rat dams exposed to varying doses of PCB 28 in the diet vs. the air to test the hypothesis that maternal exposure to PCB 28 causes neurodevelopmental deficits in weanling pups and that the profile of developmental neurotoxicity differs between inhalation and dietary exposure. This hypothesis will be tested by addressing the following aims: 1) Characterize the disposition of PCB 28 and metabolites in dams and pups following inhalational vs. dietary exposure; (2) Determine whether maternal exposure to PCB 28 via inhalation vs ingestion differentially impacts neurobehavioral outcomes in juvenile rats; and (3) Evaluate the effects of maternal exposure to PCB 28 via inhalation vs. diet on neurodevelopmental endpoints. The anticipated outcomes of these research studies include the identification of LC-PCBs as a new class of environmental contaminants that interfere with neurodevelopment and novel mechanistic data regarding how the route of exposure impacts PCB DNT. Together with findings from the parent grant, this research will impact public health by providing critical mechanistic insights regarding risk that LC-PCBs pose to the developing brain and strategies for mitigating DNT risk in vulnerable subpopulations. The training goals of this Diversity supplement include: (1) developing the trainee’s knowledge and technical skill set to enable them to successfully conduct research on environmental influences on neurodevelopmental outcomes; (2) guiding the trainee’s research activity to ensure the generation of data needed to support their preparation of a competitive F31 application and advance to candidacy; (3) enhancing the trainee’s professional skills; and (4) actively working with the trainee to build their professional networks to enhance their success in transitioning to an independent career in research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $820,318 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	002	14	11/1/2024	SUPPLEMENT FOR EXPANSION	$95,141
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	14	10/30/2024	SUPPLEMENT FOR EXPANSION	$114,992
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	14	10/28/2024	NON-COMPETING CONTINUATION	$610,185
														Subtotal = $820,318

Issue Date FY: 2024 ( Subtotal = $730,065 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	002	13	8/29/2024	SUPPLEMENT FOR EXPANSION	$21,619
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	13	11/16/2023	NON-COMPETING CONTINUATION	$611,064
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	13	1/30/2024	SUPPLEMENT FOR EXPANSION	$97,382
														Subtotal = $730,065

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	12	10/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $612,589 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	12	10/29/2021	NON-COMPETING CONTINUATION	$612,589
														Subtotal = $612,589

Issue Date FY: 2021 ( Subtotal = $642,317 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	11	12/15/2020	COMPETING CONTINUATION	$642,317
2021	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	10	7/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $642,317

Issue Date FY: 2019 ( Subtotal = $936,611 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	10	12/7/2018	NON-COMPETING CONTINUATION	$936,611
														Subtotal = $936,611

Issue Date FY: 2018 ( Subtotal = $952,122 )
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	001	9	11/22/2017	SUPPLEMENT FOR EXPANSION	$441,829
2018	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	9	11/16/2017	NON-COMPETING CONTINUATION	$510,293
														Subtotal = $952,122

Issue Date FY: 2017 ( Subtotal = $514,963 )
2017	2017	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	8	12/5/2016	NON-COMPETING CONTINUATION	$514,963
														Subtotal = $514,963

Issue Date FY: 2016 ( Subtotal = $509,395 )
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	7	11/23/2015	NON-COMPETING CONTINUATION	$509,395
														Subtotal = $509,395

Issue Date FY: 2015 ( Subtotal = $522,199 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Environmental Health	000	6	11/21/2014	COMPETING CONTINUATION	$522,199
														Subtotal = $522,199

Issue Date FY: 2013 ( Subtotal = $449,985 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	001	5	7/15/2013	NON-COMPETING CONTINUATION	$36,733
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	5	11/29/2012	NON-COMPETING CONTINUATION	$413,252
														Subtotal = $449,985

Issue Date FY: 2012 ( Subtotal = $458,921 )
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	001	4	3/14/2012	NON-COMPETING CONTINUATION	$38,425
2012	2012	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	4	12/1/2011	NON-COMPETING CONTINUATION	$420,496
														Subtotal = $458,921

Issue Date FY: 2011 ( Subtotal = $468,190 )
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	001	3	6/10/2011	NON-COMPETING CONTINUATION	$29,263
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	3	11/19/2010	NON-COMPETING CONTINUATION	$438,927
														Subtotal = $468,190

Issue Date FY: 2010 ( Subtotal = $474,003 )
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	2	11/17/2009	NON-COMPETING CONTINUATION	$430,911
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	001	2	2/2/2010	NON-COMPETING CONTINUATION	$43,092
														Subtotal = $474,003

Issue Date FY: 2009 ( Subtotal = $460,123 )
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	001	1	12/4/2008	NEW	$0
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Environmental Health	000	1	11/27/2008	NEW	$460,123
														Subtotal = $460,123

Grand Total All Awards = $8,551,801

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Diversity Supplement to Molecular and Cellular Basis of PCB Developmental Neurotoxicity (Mendieta)

Award Number: R01ES014901

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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