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The Effect of Pesticide Exposure on Cognitive and Brain Development in Latino Children: PACE5 Administrative Supplement 2

Award Number: R01ES008739
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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View Award Abstract

Concern is mounting that commonly used pesticides are detrimental to children. Children are rapidly undergoing cognitive, sensory, and motor development, and disruption of normal maturation can have life-long consequences. The extant literature strongly indicates that prenatal exposure to pesticides leads to abnormal neurobehavioral development. A recent brain imaging study further showed that prenatal pesticide exposure is associated with disrupted anatomical brain development. However, results concerning the consequences of postnatal pesticide exposure are much less conclusive. Some studies have reported neurobehavioral deficits following postnatal pesticide exposure, but just as many studies have reported no negative consequences. Currently there are no studies that assess the effects of postnatal pesticide exposure on brain development using anatomical or functional brain imaging. More conclusive research on the effects of postnatal exposure on neurodevelopment requires a highly exposed population, a longitudinal design, and careful quantification of exposure and outcomes. We propose a two-group, prospective, longitudinal study of Latino children 7 years of age with quarterly measurement of cumulative pesticide exposure using passive dosimetry wristbands as well as documentation of prenatal and early life exposure through life history techniques. Children from Latino seasonal farmworker families will be compared with children from Latino families not participating in farm work and not living in an agricultural environment. Children in Latino farmworker families are at particularly high risk of exposure. Not only are pesticides frequently used in their low quality housing, but they are also exposed to agricultural pesticides used in nearby fields brought home by parental/sibling farmworkers on clothing. Children will be followed for 2 years with measurement of neurobehavioral function at baseline, 1 year, and 2 years. Neuroimaging will be performed in a subset of participants with structural and functional brain organization assessed at baseline and two years later. Specific aims for this project are: Aim 1: Compare 2-year longitudinal and prenatal/early life pesticide exposure between children of Latino seasonal farmworkers and children of Latino parents who are not farmworkers. Aim 2: Compare 2-year longitudinal neurobehavioral and emotional and behavioral functioning among children of Latino seasonal farmworkers relative to children of Latino parents who are not farmworkers. Aim 3: Compare 2-year longitudinal anatomical and functional brain development between children of Latino seasonal farmworkers and children of Latino parents who are not farmworkers. Our nearly two decades of environmental justice (EJ) and community-based participatory research (CBPR) on pesticide exposure with farmworkers and their families provides an auspicious context to engage this vulnerable population in a study of both scientific and environmental justice importance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$109,155 )
2025	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	24	11/12/2024	SUPPLEMENT FOR EXPANSION	-$109,155
														Subtotal = -$109,155

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	001	24	8/1/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	24	7/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $220,838 )
2022	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	001	24	5/16/2022	SUPPLEMENT FOR EXPANSION	$220,838
2022	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	24	5/13/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $220,838

Issue Date FY: 2021 ( Subtotal = $563,104 )
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	24	6/16/2021	NON-COMPETING CONTINUATION	$563,104
														Subtotal = $563,104

Issue Date FY: 2020 ( Subtotal = $662,792 )
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	23	5/28/2020	NON-COMPETING CONTINUATION	$662,792
														Subtotal = $662,792

Issue Date FY: 2019 ( Subtotal = $677,962 )
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	22	5/7/2019	NON-COMPETING CONTINUATION	$598,893
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	001	22	7/30/2019	SUPPLEMENT FOR EXPANSION	$79,069
														Subtotal = $677,962

Issue Date FY: 2018 ( Subtotal = $607,111 )
2018	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	002	21	5/22/2018	NON-COMPETING CONTINUATION	$607,111
2018	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	001	20	12/5/2017	COMPETING CONTINUATION	$413,523
2018	2016	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	19	12/5/2017	EXTENSION WITH OR WITHOUT FUNDS	-$413,523
														Subtotal = $607,111

Issue Date FY: 2017 ( Subtotal = $638,539 )
2017	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	001	20	7/24/2017	COMPETING CONTINUATION	$638,539
2017	2016	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	19	7/20/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $638,539

Issue Date FY: 2016 ( Subtotal = $489,907 )
2016	2016	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	19	2/26/2016	EXTENSION WITH OR WITHOUT FUNDS	$489,907
														Subtotal = $489,907

Issue Date FY: 2015 ( Subtotal = $922,673 )
2015	2015	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	18	2/19/2015	NON-COMPETING CONTINUATION	$922,673
														Subtotal = $922,673

Issue Date FY: 2014 ( Subtotal = $939,391 )
2014	2014	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	17	2/27/2014	NON-COMPETING CONTINUATION	$939,391
														Subtotal = $939,391

Issue Date FY: 2013 ( Subtotal = $392,141 )
2013	2013	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	16	2/12/2013	SUPPLEMENT FOR EXPANSION	$392,141
														Subtotal = $392,141

Issue Date FY: 2012 ( Subtotal = $593,127 )
2012	2012	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	16	3/3/2012	NON-COMPETING CONTINUATION	$593,127
														Subtotal = $593,127

Issue Date FY: 2011 ( Subtotal = $615,410 )
2011	2011	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	002	15	7/22/2011	COMPETING CONTINUATION	$615,410
2011	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	14	2/15/2011	NON-COMPETING CONTINUATION	$0
2011	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	001	14	7/20/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $615,410

Issue Date FY: 2009 ( Subtotal = $443,326 )
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	14	3/24/2009	NON-COMPETING CONTINUATION	$443,326
														Subtotal = $443,326

Issue Date FY: 2008 ( Subtotal = $518,251 )
2008	2008	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	13	3/14/2008	NON-COMPETING CONTINUATION	$518,251
														Subtotal = $518,251

Issue Date FY: 2007 ( Subtotal = $525,356 )
2007	2007	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Environmental Health	000	12	3/29/2007	NON-COMPETING CONTINUATION	$525,356
														Subtotal = $525,356

Issue Date FY: 2006 ( Subtotal = $343,126 )
2006	2006	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	11	5/23/2006	COMPETING CONTINUATION	$343,126
														Subtotal = $343,126

Issue Date FY: 2004 ( Subtotal = $377,746 )
2004	2004	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	10	7/31/2004	NON-COMPETING CONTINUATION	$377,746
														Subtotal = $377,746

Issue Date FY: 2003 ( Subtotal = $378,225 )
2003	2003	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	9	8/28/2003	NON-COMPETING CONTINUATION	$378,225
														Subtotal = $378,225

Issue Date FY: 2002 ( Subtotal = $380,187 ) (Continued on the next page)
2002	2002	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	001	7	7/15/2002	SUPPLEMENT FOR EXPANSION	$8,630
Grand Total All Awards = $10,974,945

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The Effect of Pesticide Exposure on Cognitive and Brain Development in Latino Children: PACE5 Administrative Supplement 2

Award Number: R01ES008739

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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