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DNA Repair Genes and Proteins of the RAD52 Group

Award Number: R01ES007061
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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¿ DESCRIPTION (provided by applicant): Studies in the model eukaryote Saccharomyces cerevisiae have revealed that homologous recombination (HR) provides a major mechanism for eliminating DNA double-stranded breaks (DSBs) induced by ionizing radiation or are associated with injured DNA replication forks. During the repair process, the ends of the DNA breaks are resected nucleolytically to yield 3' ssDNA tails, which are bound by HR factors. The nucleoprotein complex thus formed then conducts a search to locate an undamaged DNA homolog, and catalyzes the formation of a DNA joint, called D-loop, with the homolog. Resolution of the D-loop can proceed via at least three mechanistically distinct pathways, two of which generate only non-crossover recombinants and are therefore more adept at genome preservation, with the remaining pathway being able to produce crossovers frequently. Proteins encoded by evolutionarily conserved genes of the RAD52 epistasis group catalyze the HR reaction. Our studies have provided insights into the mechanistic underpinnings of the HR machinery that harbors proteins of this gene group. In this renewal project, a combination of biochemical, genetic, and other cell-based approaches will be employed to (i) define the mechanism of action of the DNA motor-driven path of DSB end resection and its functional crosstalk with Exo1-mediated resection in both yeast and human cells, and (ii) delineate the roles that the conserved Rad51 paralogs fulfill in the assembly of Rad51-ssDNA nucleoprotein filaments. The results from our endeavors will allow us to formulate detailed models to elucidate HR mechanisms in eukaryotes. Given the importance of HR-mediated chromosome damage repair in tumor suppression, our work also has direct, strong relevance to cancer biology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $525,698 )
2024	2024	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	000	30	12/14/2023	NON-COMPETING CONTINUATION	$505,540
2024	2024	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	001	30	8/8/2024	SUPPLEMENT FOR EXPANSION	$20,158
														Subtotal = $525,698

Issue Date FY: 2023 ( Subtotal = $505,540 )
2023	2023	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	001	29	3/8/2023	COMPETING CONTINUATION	$505,540
2023	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	000	28	2/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $505,540

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	000	28	4/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $376,875 )
2020	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	000	28	5/11/2020	NON-COMPETING CONTINUATION	$376,875
														Subtotal = $376,875

Issue Date FY: 2019 ( Subtotal = $376,875 )
2019	2019	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	004	27	5/24/2019	NON-COMPETING CONTINUATION	$376,875
2019	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	006	26	9/24/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$9,925
2019	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Environmental Health	003	25	5/15/2019	NON-COMPETING CONTINUATION	$14,077
2019	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Environmental Health	005	25	9/24/2019	NON-COMPETING CONTINUATION	-$9,925
2019	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Environmental Health	000	25	3/19/2019	NON-COMPETING CONTINUATION	-$164,077
2019	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	002	26	5/14/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$14,077
2019	2018	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Environmental Health	001	26	3/20/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$164,077
														Subtotal = $376,875

Issue Date FY: 2018 ( Subtotal = $376,875 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Environmental Health	000	25	5/28/2018	NON-COMPETING CONTINUATION	$376,875
														Subtotal = $376,875

Issue Date FY: 2017 ( Subtotal = $376,875 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	NEW HAVEN	USA	Environmental Health	000	24	5/24/2017	NON-COMPETING CONTINUATION	$376,875
														Subtotal = $376,875

Issue Date FY: 2016 ( Subtotal = $376,688 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	23	5/20/2016	COMPETING CONTINUATION	$376,688
														Subtotal = $376,688

Issue Date FY: 2014 ( Subtotal = $390,711 )
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	22	3/21/2014	NON-COMPETING CONTINUATION	$390,711
														Subtotal = $390,711

Issue Date FY: 2013 ( Subtotal = $387,126 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	21	4/10/2013	NON-COMPETING CONTINUATION	$355,521
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	001	21	7/9/2013	NON-COMPETING CONTINUATION	$31,605
														Subtotal = $387,126

Issue Date FY: 2012 ( Subtotal = $395,353 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	20	3/26/2012	NON-COMPETING CONTINUATION	$395,353
														Subtotal = $395,353

Issue Date FY: 2011 ( Subtotal = $395,143 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	19	3/21/2011	NON-COMPETING CONTINUATION	$370,906
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	001	19	6/3/2011	NON-COMPETING CONTINUATION	$24,237
														Subtotal = $395,143

Issue Date FY: 2010 ( Subtotal = $400,116 )
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	18	8/9/2010	COMPETING CONTINUATION	$400,116
														Subtotal = $400,116

Issue Date FY: 2009 ( Subtotal = $360,827 )
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	17	6/25/2009	NON-COMPETING CONTINUATION	$360,827
														Subtotal = $360,827

Issue Date FY: 2008 ( Subtotal = $360,827 )
2008	2008	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	16	6/17/2008	NON-COMPETING CONTINUATION	$360,827
														Subtotal = $360,827

Issue Date FY: 2007 ( Subtotal = $368,191 )
2007	2007	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	15	6/21/2007	NON-COMPETING CONTINUATION	$368,191
														Subtotal = $368,191

Issue Date FY: 2006 ( Subtotal = $379,188 )
2006	2006	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	14	6/27/2006	NON-COMPETING CONTINUATION	$379,188
														Subtotal = $379,188

Issue Date FY: 2005 ( Subtotal = $388,313 )
2005	2005	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	13	5/2/2005	COMPETING CONTINUATION	$388,313
														Subtotal = $388,313

Issue Date FY: 2004 ( Subtotal = $318,503 )
2004	2004	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	12	6/30/2004	NON-COMPETING CONTINUATION	$318,503
														Subtotal = $318,503

Issue Date FY: 2003 ( Subtotal = $318,872 )
2003	2003	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	NEW HAVEN	USA	Environmental Health	000	11	8/21/2003	NON-COMPETING CONTINUATION	$318,872
														Subtotal = $318,872

Grand Total All Awards = $8,663,901

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DNA Repair Genes and Proteins of the RAD52 Group

Award Number: R01ES007061

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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