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Autonomous Hybrid Bioprinting of Hierarchical Perfusable Vascularized Liver Tissues

Award Number: R01EB038366
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/05/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2030

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Autonomous Hybrid Bioprinting of Hierarchical Perfusable Vascularized Liver Tissues - Abstract With the progress in vascular bioengineering, three-dimensional (3D) bioprinting has emerged as a potential approach for generating physiologically relevant blood vessels with the ability to grow, remodel, and repair vascular structures in vitro and in vivo. Different 3D bioprinting techniques and strategies have been investigated and established over the past years to fabricate biomimetic blood vessels and are constantly being refined and improved. To this end, sacrificial bioprinting technologies developed in the past few years have provided a convenient solution for this problem due to its capability to fabricate interconnected microchannels of arbitrary geometries and connectivity. However, although sacrificial bioprinting provides a versatile method to create vessel-like structures, there are two major obstacles preventing its further growth, i.e., the patterns attainable are relatively simple, and the resolutions attainable for the perfusable vessels are insufficient in most cases, both due to the extrusion bioprinting method that has been exclusively utilized in sacrificial bioprinting so far. We accordingly propose to develop an innovative hybrid multi-material and multi- method autonomous printing (HM2AP) technology integrating aerosol jet sacrificial printing and extrusion bioprinting, which enables facile construction of 3D complex and hierarchical vascular structures with feature sizes ranging from 10-100 µm embedded within tissue microenvironments. Successful completion of this project will build a paradigm-shifting bioprinting technology using which complex and hierarchical vessels of varying dimensions can be readily generated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $662,737 )
2026	2026	UNIVERSITY OF NOTRE DAME DU LAC	940 GRACE HALL	NOTRE DAME	IN	46556	ST JOSEPH	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	3/2/2026	NEW	$662,737
														Subtotal = $662,737

Grand Total All Awards = $662,737

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Autonomous Hybrid Bioprinting of Hierarchical Perfusable Vascularized Liver Tissues

Award Number: R01EB038366

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/05/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2030

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