Wednesday, April 2, 2025
4/2/2025
Instant and reversible wet tissue adhesive tape - ABSTRACT Minimally invasive surgery (MIS) is favored for its benefits, such as reduced pain, shorter recovery times, and minimized scarring, with 7.5 million laparoscopies performed worldwide in 2015. Procedures like lung cancer surgery, tubal ligation, cholecystectomy, gastric bypass, myomectomy, and prostatectomy are predominantly conducted using MIS, a trend expected to grow by up to 15% in the next 5–10 years. However, adapting surgical tools for the confined environments of MIS remains challenging. Traditional retractors and stabilizers often cause tissue damage and can detach during procedures, and their bulkiness limits their effectiveness. Effective hemostasis in gastrointestinal (GI) surgeries using endoscopic methods is a critical unmet need, as current methods like mechanical clips, thermal coagulation, and injection therapies face challenges with precision, potential tissue damage, and risk of rebleeding. Tissue adhesives that can adhere to wet tissues in confined environments could provide effective wound closure and tissue retraction. Currently available tissue adhesives, such as fibrin sealants (e.g., Tisseel™), cyanoacrylate-based glues (e.g., Histoacryl™, Dermabond™, Omnex™), and protein/peptide-based glues (e.g., BioGlue™, TissuGlu™), have limitations such as limited adhesion strength, inability to reposition, and toxicity, making them less suitable for MIS. An ideal tissue adhesive for MIS should be easy to apply, rapidly adhere to wet tissue, repositionable, avoid reactive chemistry or ionizing radiation, withstand multiple extension/compression cycles, and be biocompatible and resorbable. This proposal aims to develop a novel PSB system for MIS. Pressure-sensitive adhesives (PSAs) form instant, reversible attachments through viscoelastic properties and have potential applications in MIS by enabling easy repositioning and removal of surgical equipment, minimizing tissue damage, and enhancing surgical adaptability. Despite their potential, available medical PSAs do not attach to wet internal organs because water on the wet tissues blocks the direct contact of the viscoelastic PSAs to the tissue. Our preliminary studies on a PSB based on poly(glycerol sebacate) (PGS) combined with poly(ethylene glycol) (PEG) show that it can adhere instantly to wet tissues like the heart and lungs, even in the presence of blood or body fluid. The PSB can be integrated with medical devices without specific surface chemistry limitations. Reversible adhesion provides atraumatic detachment and reattachment, reducing tissue damage and assisting surgeons with adaptable positioning during procedures. Aim 1. Fabricate PSB with tunable viscoelastic properties and adhesive properties to different types of tissues. Aim 2. Explore the PBS's performance for minimally invasive applications. Aim 3. Evaluate the feasibility of PSB for translational MIS scenarios – hemostatic adhesive and tissue stabilization during endoscopic procedures.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).