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Universal optical coherence polarimetry

Award Number: R01EB033321
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Universal optical coherence polarimetry - Project Summary The goal of this research is to enable the integration of advanced polarimetric imaging into existing optical coherence tomography (OCT) hardware and expedite its clinical translation. OCT is essential in contemporary ophthalmology and is routinely used to guide percutaneous coronary interventions. Extending OCT to measure polarization effects arising from tissue anisotropy affords contrast between tissues that are indiscernible in OCT’s conventional scattering signal. Polarization provides insight into the make-up and physical orientation of tissue microstructure beyond the spatial resolution of OCT. Intravascular polarimetry with polarization-sensitive (PS)-OCT offers refined insight into coronary atherosclerosis in patients suffering from myocardial infarction and other coronary syndromes and may improve patient management and guidance of percutaneous interventions. In the eye, PS-OCT has shown promise to detect alterations of the retinal nerve fiber layer (RNFL) that precede the degeneration of its retinal ganglion cell axons encountered in glaucoma, the leading cause of irreversible blindness. However, the dissemination of PS-OCT relies on adoption by a wider community, which has been hindered by the excessive hardware complexity of conventional PS-OCT. This project develops a universal and robust signal processing framework for optical coherence polarimetry (OCP) that accommodates novel simplified hardware implementations. Coherent measurements of the polarization response to propagation through tissue conventionally require polarization-diverse detection and illumination with two input states. To avoid the acute complexity of multiplexing two input states, prototype PS- OCT systems currently employed for imaging the coronary arteries or the lung use sequential input modulation. Still, this remains incompatible with the substantial commercial OCT instrument infrastructure available in the clinic today. OCP capitalizes on an intrinsic symmetry constraint manifesting in round-trip measurements performed with OCT, which enables the recovery of polarization effects from previously ill-conditioned configurations and enables adaptation of existing commercial OCT instruments to perform advanced tissue polarimetry. Aim 1 integrates concepts from magnetic resonance image reconstruction into OCP to compensate for detrimental system effects and suppress speckle-induced polarization noise. Aim 2 adapts OCP to commercial clinical intravascular OCT instruments using a single, spectrally varying input state and polarization diverse detection for investigating plaque rupture and healing in patients. Aim 3 performs OCP with retinal OCT instruments using a single spectrometer, relying on a rotating waveplate module, fitted into the accessible round-trip path and repeated scan patterns established for OCT angiography. RNFL birefringence will be investigated with the adapted clinical instruments in glaucoma patients and healthy controls. Combined, this work will provide the clinical OCT imaging community with a toolbox of algorithms that transforms existing OCT instruments with minimal modification into powerful polarimetric imaging platforms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	12/15/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $522,807 )
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	5/1/2025	NON-COMPETING CONTINUATION	$522,807
2025	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	4/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $522,807

Issue Date FY: 2024 ( Subtotal = $533,210 )
2024	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/20/2024	NON-COMPETING CONTINUATION	$533,210
														Subtotal = $533,210

Issue Date FY: 2023 ( Subtotal = $477,748 )
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	4/24/2023	NON-COMPETING CONTINUATION	$477,748
														Subtotal = $477,748

Issue Date FY: 2022 ( Subtotal = $486,248 )
2022	2022	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	7/7/2022	NEW	$486,248
														Subtotal = $486,248

Grand Total All Awards = $2,020,013

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Universal optical coherence polarimetry

Award Number: R01EB033321

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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