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NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing

Award Number: R01EB031813
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/05/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing - NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing PROJECT SUMMARY Our goal is to develop a portable, non-invasive, measurement of volume status to improve quality of life and reduce morbidity and mortality among hospitalized patients. Maintenance of euvolemic status and proper fluid balance are critical for health and improved outcomes for renal, cardiovascular, and many other disease types as well as in healthy populations prone to dehydration such as athletes and soldiers. Our laboratory has previously constructed a portable single sided magnetic resonance (MR) sensors that is capable of resolving individual fluid compartments (subcutaneous, intramuscular, etc.) within tissue. This sensor was used in a pilot clinical trial with end stage kidney disease patients. Quantitative MRI results on these patients demonstrated that the first sign of fluid overload among hemodialysis patients is an expanded skeletal muscle extracellular fluid (ECF) space. The early stage nature of the technology was evident in that study as the portable sensor could not unambiguously differentiate skeletal muscle tissue from subcutaneous tissue. The proposed research includes the design of a new portable low-field MR sensor and improved signal processing that will allow it to capture the same quantitative assessment of volume status currently achievable with quantitative MRI (qMRI). We measure local fluid distribution in the target in vivo tissue compartment. In the case of fluid volume status, our hypothesis is that a localized skeletal muscle measurement is representative of systemic fluid distribution based on results from a prior study1. The optimized sensor will have the sensitive region of the magnetic field designed to target the skeletal muscle. The existing and newly designed portable MR sensors will be used to measure intramuscular fluid distribution in end stage kidney disease patients undergoing dialysis treatment as well as in healthy athletes experiencing exercise induced fluid loss. The sensor measurement will allow for quantification of volume overload (hypervolemia) or depletion (hypovolemia) and allow for its use in clinical decision making. Dialysis patients and athletes are the target population for the following proposal. The rapid reduction in fluid volume during a dialysis session and exercise respectively provides the ideal clinical context for performing repeated fluid status measurements.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $540,178 )
2025	2025	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	6/25/2025	NON-COMPETING CONTINUATION	$54,018
2025	2025	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	2/18/2025	NON-COMPETING CONTINUATION	$486,160
														Subtotal = $540,178

Issue Date FY: 2024 ( Subtotal = $530,132 )
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	2/1/2024	NON-COMPETING CONTINUATION	$486,856
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	5/27/2024	NON-COMPETING CONTINUATION	$43,276
														Subtotal = $530,132

Issue Date FY: 2023 ( Subtotal = $540,951 )
2023	2023	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	2/7/2023	NON-COMPETING CONTINUATION	$540,951
														Subtotal = $540,951

Issue Date FY: 2022 ( Subtotal = $581,837 )
2022	2022	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	5/4/2022	NEW	$581,837
														Subtotal = $581,837

Grand Total All Awards = $2,193,098

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NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing

Award Number: R01EB031813

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/05/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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