Monday, December 22, 2025 12/22/2025

SOCAL: Privacy-protecting Sharing Of Clinical Data Across Laboratories

Award Number: R01EB031030
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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SOCAL: Privacy-protecting Sharing Of Clinical Data Across Laboratories - Project Summary Privacy and security of personal information has become one of the major grand challenges in modern society, especially for healthcare studies. Re-identification risks and data breaches require new policies and regulations for data sharing across healthcare institutions and research laboratories. While policy cannot solve the problem on its own, advanced technologies that work hand in hand with policy are important to address the privacy/security concerns. Predictive analytics can support quality improvement, clinical research, and eventually impact patient health status. Extensive clinical variable information and voluminous data records from multiple institutions and laboratories are necessary to further improve the performance of modeling approaches and to identify medication-outcome associations for diseases. Nonetheless, the transfer of such sensitive data among institutions/laboratories can present serious privacy risks, which can jeopardize NIH’s mission. Aiming at mitigating the privacy problem while increasing predictive capability via cross-institutional modeling, prior studies proposed distributed methods to exchange only the predictive models, but not patient data. However, these methods still pose many challenges to the clinical cross-institutional learning problem, including the need for more comprehensive clinical variables and more patient records to achieve better prediction discrimination and build more generalizable models, the necessity for discovery/alleviation of data manipulation to increase the trustworthiness of the collaboratively trained models, and the requirement for more validation to ensure usability. In this proposal, we plan to develop SOCAL (Privacy-protecting Sharing Of Clinical data Across Laboratories), a distributed framework addressing these challenges by integrating vertical/horizontal modeling methods to include both more complete variables and more records, discovering/alleviating data manipulation incidents using models recorded on blockchain, and conducting controlled experiments and designing/testing a web portal with physician-researchers to increase the usability of the system. SOCAL will be evaluated on a Coronavirus Disease 2019 (COVID-19) dataset from five University of California (UC) Health medical centers. We expect the knowledge/capability of collaborative modeling can be improved, the trustworthiness of the learning process can be enhanced, and the framework will be ready for use. SOCAL is innovative because it will be a new integration methodology for vertical/horizontal modeling, a novel data manipulation resisting methods, and a hardened prototype for a practical blockchain application. We anticipate a powerful impact of the SOCAL framework to largely reduce the privacy concerns of predictive modeling tasks for various stakeholders, including healthcare providers, clinical researchers, and patients. Upon completion, SOCAL can accelerate the development of methods/technologies to increase willingness of institutions to participate in such a collaboration for improving the effectiveness of healthcare.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	12/9/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $332,554 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	4	7/1/2025	NON-COMPETING CONTINUATION	$332,554
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	3	2/13/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$417,500
2025	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	2/13/2025	NON-COMPETING CONTINUATION	-$327,242
2025	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	2/13/2025	NEW	-$90,258
														Subtotal = $332,554

Issue Date FY: 2024 ( Subtotal = $343,314 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	7/17/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$343,314
2024	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $343,314

Issue Date FY: 2023 ( Subtotal = $327,242 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	7/20/2023	NON-COMPETING CONTINUATION	$327,242
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	10/17/2022	NEW	$0
														Subtotal = $327,242

Issue Date FY: 2022 ( Subtotal = $328,388 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/23/2022	NEW	$328,388
														Subtotal = $328,388

Grand Total All Awards = $1,331,498

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SOCAL: Privacy-protecting Sharing Of Clinical Data Across Laboratories

Award Number: R01EB031030

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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