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Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view

Award Number: R01EB029596
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/07/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view - ABSTRACT The ultimate goal of this project is to address the unmet clinical need in breast cancer screening for women with high breast density. This population (BI-RADS density grades C and D) accounts for nearly half of women. The high breast density reduces mammography sensitivity to as low as 62%, and it is also associated with a two-fold higher risk of breast cancer (American College of Obstetricians and Gynecologists, Management of Women With Dense Breasts Diagnosed by Mammography, 2016). While 30 states have now passed breast density notification laws, there is no promising modality for large-scale screening of patients with dense breasts. For instance, the breast ultrasound (US) is operator-dependent, and has limited sensitivity and a high false positive rate; while dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI) is limited by its high cost, required injection of gadolinium contrast, and limited availability. To address this issue, this project will develop a three- dimensional (3D) breast screening system with both photoacoustic (PA) and US imaging capabilities. The proposal is capitalized on the team’s recent advances in the double-scan PA technology, which utilized two linear transducer arrays and two linear optical fiber bundles to image a slightly compressed breast from both the cranial and caudal (CC) sides. With a novel co-planar optical illumination and acoustic detection design, the prototype system successfully imaged through a 7-cm-thick compressed breast. This depth has never been achieved by any other PA breast imaging systems. The CC-view detection also presents images in a form that is familiar to radiologists. In addition, the system is portable and images the patient in a standing pose, both of these features will significantly facilitate clinical workflow. This R01 project will further advance the dual-scan system to achieve better breast coverage, higher spatial resolution, better US capability, and multi-parametric quantification of breast tissue. To ensure successful implementation of the project, the team possesses multidisciplinary expertise in photoacoustics, ultrasound, computational informatics, biostatistics, as well as breast oncology and radiology. The project has also secured support from the Buffalo’s two busiest breast imaging centers ― Roswell Park Cancer Institute and Windsong Radiology Group. The specific aims of the project are as follows: Aim 1. Develop a compact double-scan photoacoustic and ultrasonic breast imaging system. Aim 2. Develop photoacoustic and ultrasound image acquisition and processing algorithms. Aim 3. Investigate photoacoustic and ultrasonic features of breast malignancy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$440 )
2025	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/22/2025	NON-COMPETING CONTINUATION	-$440
														Subtotal = -$440

Issue Date FY: 2023 ( Subtotal = $357,289 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	1/30/2023	NON-COMPETING CONTINUATION	$357,289
														Subtotal = $357,289

Issue Date FY: 2022 ( Subtotal = $357,357 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	2/23/2022	NON-COMPETING CONTINUATION	$321,620
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	6/30/2022	NON-COMPETING CONTINUATION	$35,737
														Subtotal = $357,357

Issue Date FY: 2021 ( Subtotal = $354,398 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	3/22/2021	NON-COMPETING CONTINUATION	$28,931
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	2	6/15/2021	NON-COMPETING CONTINUATION	$0
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	12/19/2020	NON-COMPETING CONTINUATION	$325,467
														Subtotal = $354,398

Issue Date FY: 2020 ( Subtotal = $342,791 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/7/2020	NEW	$342,791
														Subtotal = $342,791

Grand Total All Awards = $1,411,395

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Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view

Award Number: R01EB029596

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/07/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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