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Multi-Task MR Simulation for Abdominal Radiation Treatment Planning

Award Number: R01EB029088
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Multi-Task MR Simulation for Abdominal Radiation Treatment Planning - The accuracy of radiation treatment planning (RTP) heavily influences the effectiveness of external beam radiotherapy (EBRT). Individualized RTP begins with a “simulation”, in which the patient in a treatment position is commonly scanned using computed tomography (CT) to define the treatment target and organs at risk (OARs). When soft-tissue contrast is inadequate to support accurate target and OAR delineation in CT based RTP, conservatively large treatment margins are used to avoid a geometric miss. The crude treatment prevents delivering sufficient radiation dose to the tumor without exceeding the tolerance of surrounding normal tissues. Magnetic resonance (MR) can be used as a simulation platform complementary to CT for improved soft-tissue conspicuity. Yet, such a complicated, costly and tedious multi-modal RTP workflow along with unavoidable systematic MR-CT co-registration errors has limited its applications in EBRT, especially at the abdominal site whereby anatomies are highly mobile. Over the past few years, there is a keen interest in the integration of MR alone into RTP and even the therapy workflow (i.e. MR-guided radiotherapy, MRgRT). The abdomen poses critical challenges to MR simulation. Current MR imaging sequences are suboptimal to produce motion-free images and resolve respiratory motion. MR data processing for abdominal RTP is underdeveloped. Contouring of target and OARs typically relies on manual, tedious procedures that are time-consuming and variation-prone. In this proposal, we will substantially improve the MR acquisition and automated multi-organ segmentation, so the potential of MR as a simulation modality can be fully unleashed for abdominal EBRT. Three specific aims will be completed. In Aim 1, we will develop and validate a standalone multi-task MR (MT-MR) sequence dedicated to abdominal MR simulation. In Aim 2, we will develop an MT-MR simulation based multi-organ auto- segmentation tool. In Aim 3, we will optimize a deep learning-based dose prediction model and assess the effectiveness of the MT-MR based RTP workflow in adaptive stereotactic body radiotherapy planning of pancreatic cancer patients. Successful completion of the project will significantly promote the clinical adoption of MR simulation for abdominal RTP, which will improve treatment precision and outcomes. Moreover, the developed techniques will open the door to future studies aiming at optimizations in both cancer diagnosis and radiotherapy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$6,853 )
2025	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	7/28/2025	NON-COMPETING CONTINUATION	-$6,853
														Subtotal = -$6,853

Issue Date FY: 2023 ( Subtotal = $681,141 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/14/2023	NON-COMPETING CONTINUATION	$681,141
														Subtotal = $681,141

Issue Date FY: 2022 ( Subtotal = $724,120 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	4/8/2022	NON-COMPETING CONTINUATION	$723,589
2022	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	9/26/2022	NEW	$531
														Subtotal = $724,120

Issue Date FY: 2021 ( Subtotal = $507,076 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	005	2	8/5/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$451,546
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	3/29/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$507,076
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	2	5/10/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	2	5/28/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2021	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	3/28/2021	NEW	$0
2021	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	1	8/5/2021	NEW	-$451,546
														Subtotal = $507,076

Issue Date FY: 2020 ( Subtotal = $556,712 )
2020	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/17/2020	NEW	$556,712
														Subtotal = $556,712

Grand Total All Awards = $2,462,196

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Multi-Task MR Simulation for Abdominal Radiation Treatment Planning

Award Number: R01EB029088

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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