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Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance

Award Number: R01EB028283
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance - ABSTRACT The recent expansion of lung cancer screening programs in the United States has led to a significant increase in the number of lung lesions requiring sampling to evaluate their malignancy status. Bronchoscopic based peripheral lung biopsy offers the lowest rate of procedural complication. However, diagnostic yields have remained moderate, primarily due to the lack of high resolution, real-time imaging guidance. Techniques such as endobronchial ultrasound and electromagnetic navigational bronchoscopy offer some guidance for the interventionalist, but remain limited for the necessary fine localization of the biopsy needle tip and lesion just prior to sampling. Standard CT based imaging approaches are too expensive and cumbersome for intra- procedural use. We have developed a stationary digital chest tomosynthesis imaging approach based on the linear x-ray array based on the carbon nanotube field emission sources. Our approach offers the potential for rapid, high resolution in-plane imaging combined with low-dose stereoscopic imaging, all without the need for any physical motion of the x-ray source or detector. We seek to refine our stationary chest tomosynthesis system, evaluate rapid CT to tomosynthesis image registration techniques and integrate the software control and guidance system in a system for pre-clinical large animal evaluation. Our academic-industrial partnership will incorporate a team of physicists, computer scientists, radiologists and interventional pulmonologists to develop this system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$5 )
2025	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/18/2025	NON-COMPETING CONTINUATION	-$5
														Subtotal = -$5

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	3/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $711,589 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/18/2023	NON-COMPETING CONTINUATION	$711,589
														Subtotal = $711,589

Issue Date FY: 2022 ( Subtotal = $706,479 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/11/2022	NON-COMPETING CONTINUATION	$706,479
														Subtotal = $706,479

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $732,676 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	8/20/2020	NON-COMPETING CONTINUATION	$732,676
														Subtotal = $732,676

Issue Date FY: 2019 ( Subtotal = $770,451 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/9/2019	NEW	$770,451
														Subtotal = $770,451

Grand Total All Awards = $2,921,190

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Stationary Digital Tomosynthesis for Transbronchial Biopsy Guidance

Award Number: R01EB028283

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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