Sunday, October 1, 2023 10/1/2023

Personalized Functional Network Modeling to Characterize and Predict Psychopathology in Youth

Award Number: R01EB022573
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

ABSTRACT Intrinsic functional connectivity magnetic resonance imaging is a powerful tool to study the organization of functional networks (FNs) in the human brain. Rich and accumulating evidence demonstrates that FNs undergo predictable normative development in youth, and that abnormal development is associated with diverse psychopathology. Recent work based on advances in image analytics has established that FNs are in fact person-specific. When paired with large-scale neuroimaging datasets, person-specific FNs provide unprecedented translational opportunities for the development of new diagnostics that could guide personalized treatments for neuropsychiatric illnesses. However, the translational promise of person-specific FNs is at present hindered by several obstacles. First, current methods compute personalized FNs at a specific scale, despite clear evidence that the brain is a multi-scale system with a hierarchical functional organization. Second, to enforce correspondence across different subjects personalized FNs are typically computed under certain constraints, which may yield biased results. Third, deep learning has achieved mixed success in neuroimaging data analysis partially due to the fact that ad-hoc network architecture is typically adopted and feature learning capability is often deprived by adopting pre-engineered rather than learned features. Fourth, to correct site effects of neuroimaging measures from multiple datasets of large-scale neuroimaging studies current methods typically attempt to harmonize data prior to statistical modeling, resulting in loss of valuable information. Fifth, longitudinal neuroimaging and clinical data are increasingly available, but effective analytic tools for longitudinal data are scarce. Last but not least, deep learning algorithms have been developed to analyze fcMRI data but are often released as poorly documented source code, limiting both reproducibility and adoption by translational researchers. In this application, we build on the success of the prior award period to address these limitations by developing, validating, and disseminating tools that characterize brain functional organization at an individual subject level. We will leverage complementary large-scale studies of brain development to validate our methods and delineate how abnormal development of FNs is associated with major dimensions of psychopathology in youth, including depression, anxiety, psychosis, and ADHD-spectrum symptoms. Specifically, we will develop novel methods to 1) accurately identify bias-free personalized FNs with a multiscale hierarchical organization; 2) robustly predict psychiatric symptom dimensions using personalized FNs with optimized deep neural network architecture and integrated site-effect correction, and 3) effectively model longitudinal data of FNs to create predictive models of psychopathology. These tools will be released in a freely available, containerized software package to ensure frictionless portability across computing platforms and full reproducibility.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $653,448 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	4/12/2023	NON-COMPETING CONTINUATION	$653,448


Issue Date FY: 2022 ( Subtotal = $655,048 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	5/30/2022	NON-COMPETING CONTINUATION	$653,448
2022	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	9/26/2022	NON-COMPETING CONTINUATION	$1,600


Issue Date FY: 2021 ( Subtotal = $655,383 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	8/24/2021	COMPETING CONTINUATION	$66,520
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	8/2/2021	COMPETING CONTINUATION	$655,383
2021	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	8/24/2021	NON-COMPETING CONTINUATION	-$66,520


Issue Date FY: 2019 ( Subtotal = $522,460 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	4/30/2019	NON-COMPETING CONTINUATION	$522,460


Issue Date FY: 2018 ( Subtotal = $549,838 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/7/2018	NON-COMPETING CONTINUATION	$549,838


Issue Date FY: 2017 ( Subtotal = $549,838 )
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	5/18/2017	NON-COMPETING CONTINUATION	$549,838


Issue Date FY: 2016 ( Subtotal = $491,014 )
2016	2016	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/30/2016	NEW	$491,014


Grand Total All Awards = $4,077,029

Sum of Action Amount is $4,077,029;

Grand Total = $4,077,029

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Personalized Functional Network Modeling to Characterize and Predict Psychopathology in Youth

Award Number: R01EB022573

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer