Saturday, November 23, 2024 11/23/2024

OpenIGTLink: a network communication interface for closed-loop image-guided interventions

Award Number: R01EB020667
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract In this cycle of the project, we will extend OpenIGTLink software to enable individualized precision guidance, where patient-specific characteristics are taken into account in the planning and control process for image- guided robotic interventions (IGRI) to achieve a better clinical outcome. In particular, we will focus on improving needle placement accuracy for IGRI of the prostate, as a simple, and yet a representative application of individualized precision guidance. Percutaneous needle placement plays a fundamental role in both the diagnosis and treatment of prostate cancer. Nearly one million prostate biopsies are performed annually in the United States, where tissues are sampled from the prostate with a biopsy needle for pathological examination. The confirmed lesions may then be focally treated with brachytherapy or thermal ablation using applicator needles depending on clinical indications and patient preference. For those procedures, accurate needle placement is essential to avoid false-negatives or ensure an optimal dose distribution. The demand for accurate needle placement is growing in recent years, as clinicians are now capable of pinpointing subregions in a heterogeneous tumor thanks to the recent progress in imaging technologies, particularly multiparametric magnetic resonance imaging (MRI). However, the in vivo accuracies achieved by previous studies have never matched the level of tumor subregion targeting due to needle deviation as a result of physical interaction between the needle and the heterogeneous tissue. To address this issue, we will incorporate needle deviation models in an IGRI system using OpenIGTLink software. Our hypothesis is that the models adapted to individual patients will enable avoidance or compensation of needle deviation, leading to an improved in vivo needle placement accuracy. The project comprises the following four specific aims: (Aim 1) Develop a biomechanical model with image-based semi-automatic model generation; (Aim 2) Develop a data-driven prediction model and hybridize with the biomechanical model; (Aim 3) Extend the IGRI platform for model- based closed-loop control using OpenIGTLink; (Aim 4) Evaluate biomechanical, data-driven, and hybrid models in vivo needle placement.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	11/18/2024	NON-COMPETING CONTINUATION	$0
2025	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	11/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $635,108 )
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	3/7/2024	NON-COMPETING CONTINUATION	$583,265
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	4/29/2024	NON-COMPETING CONTINUATION	$51,843
														Subtotal = $635,108

Issue Date FY: 2023 ( Subtotal = $643,330 )
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	2/3/2023	NON-COMPETING CONTINUATION	$643,330
														Subtotal = $643,330

Issue Date FY: 2022 ( Subtotal = $929,292 )
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	7/25/2022	NON-COMPETING CONTINUATION	$0
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	4/22/2022	NON-COMPETING CONTINUATION	$64,214
2022	2022	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	5	8/29/2022	SUPPLEMENT FOR EXPANSION	$287,179
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	2/3/2022	NON-COMPETING CONTINUATION	$577,899
														Subtotal = $929,292

Issue Date FY: 2021 ( Subtotal = $701,392 )
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	4/9/2021	COMPETING CONTINUATION	$701,392
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	4	5/26/2021	COMPETING CONTINUATION	$0
2021	2017	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	1/26/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $701,392

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/10/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $399,375 )
2017	2017	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/26/2017	NON-COMPETING CONTINUATION	$399,375
														Subtotal = $399,375

Issue Date FY: 2016 ( Subtotal = $399,375 )
2016	2016	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	6/4/2016	NON-COMPETING CONTINUATION	$399,375
														Subtotal = $399,375

Issue Date FY: 2015 ( Subtotal = $392,643 )
2015	2015	BRIGHAM & WOMEN`S HOSPITAL	10 VINING STREET	BOSTON	MA	02115	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/29/2015	NEW	$392,643
														Subtotal = $392,643

Grand Total All Awards = $4,100,515

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OpenIGTLink: a network communication interface for closed-loop image-guided interventions

Award Number: R01EB020667

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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