Friday, May 9, 2025 5/9/2025

Coherence-Based Fetal Ultrasonic Imaging

Award Number: R01EB017711
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Coherence-Based Fetal Ultrasonic Imaging - Abstract Ultrasonic imaging is widely used to monitor fetal growth and development during the first and second trimester, and multiple studies document the resultant positive impacts on fetal and maternal outcomes. However, current methods fail to provide adequate visualization of key structures in many patients, and alternative imaging modes are rarely available to these patients. We have developed novel ultrasonic beamforming methods that utilize the spatial coherence of backscattered echoes. These methods, in simulation, phantom, and blinded-observer clinical studies, show markedly improved image quality over conventional ultrasonic images, especially in difficult-to-image patients. We propose extend our theory of coherence imaging to 1.5D and 2D arrays and to very large arrays. Using such advanced arrays, we propose clinical studies to assess the role of coherence imaging in key fetal diagnostic tasks in first trimester and second trimester scans. Quantitative image quality metrics and observer studies are proposed to compare B-mode and coherence images with an emphasis on difficult-to-image patients for whom current imaging methods fail. Related studies will measure the contribution of various sources of image degradation in fetal scans. If successful, the proposed research could lead to a new class of ultrasonic beamforming methods that operate in imaging environments in which current methods fail.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $429,966 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	12	1/16/2025	NON-COMPETING CONTINUATION	$429,966
														Subtotal = $429,966

Issue Date FY: 2024 ( Subtotal = $468,184 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	11	6/7/2024	NON-COMPETING CONTINUATION	$38,218
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	11	1/22/2024	NON-COMPETING CONTINUATION	$429,966
														Subtotal = $468,184

Issue Date FY: 2023 ( Subtotal = $494,738 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	10	2/17/2023	NON-COMPETING CONTINUATION	$494,738
2023	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	9	11/28/2022	COMPETING CONTINUATION	$55,050
2023	2021	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	11/28/2022	NON-COMPETING CONTINUATION	-$55,050
														Subtotal = $494,738

Issue Date FY: 2022 ( Subtotal = $477,738 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	9	2/11/2022	COMPETING CONTINUATION	$421,531
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	9	7/5/2022	COMPETING CONTINUATION	$56,207
														Subtotal = $477,738

Issue Date FY: 2021 ( Subtotal = $348,226 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	8	5/26/2021	NON-COMPETING CONTINUATION	$0
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	4/23/2021	NON-COMPETING CONTINUATION	$348,226
														Subtotal = $348,226

Issue Date FY: 2020 ( Subtotal = $355,594 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	4/9/2020	NON-COMPETING CONTINUATION	$355,594
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	11/8/2019	NON-COMPETING CONTINUATION	$0
2020	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	5	8/12/2020	COMPETING CONTINUATION	$0
2020	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	4	8/12/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $355,594

Issue Date FY: 2019 ( Subtotal = $355,306 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	6	4/9/2019	NON-COMPETING CONTINUATION	$355,306
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	12/27/2018	COMPETING CONTINUATION	$1,371
2019	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	12/27/2018	NON-COMPETING CONTINUATION	-$1,371
														Subtotal = $355,306

Issue Date FY: 2018 ( Subtotal = $353,942 )
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	6/19/2018	COMPETING CONTINUATION	$353,942
														Subtotal = $353,942

Issue Date FY: 2017 ( Subtotal = $346,418 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	6/9/2017	NON-COMPETING CONTINUATION	$346,418
														Subtotal = $346,418

Issue Date FY: 2016 ( Subtotal = $346,854 )
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	5/27/2016	NON-COMPETING CONTINUATION	$346,854
														Subtotal = $346,854

Issue Date FY: 2015 ( Subtotal = $340,327 )
2015	2015	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/1/2015	NON-COMPETING CONTINUATION	$340,327
														Subtotal = $340,327

Issue Date FY: 2014 ( Subtotal = $337,105 )
2014	2014	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	6/23/2014	NEW	$337,105
														Subtotal = $337,105

Grand Total All Awards = $4,654,398

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Coherence-Based Fetal Ultrasonic Imaging

Award Number: R01EB017711

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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