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Combining zwitterionic hydrogels with S100A9 inhibition for postoperative abdominal adhesion prevention

Award Number: R01DK149648
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/08/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Combining zwitterionic hydrogels with S100A9 inhibition for postoperative abdominal adhesion prevention - PROJECT SUMMARY Postoperative abdominal adhesions affect more than half of patients following abdominal surgery, leading to significant complications, and imposing a substantial health and economic burden. Current commercial anti- adhesion materials can alleviate postoperative adhesions to some extent, but they have several intrinsic disadvantages, and their efficacy is far from ideal. In addition, a deeper understanding of the intricate interactions among inflammatory response, matrix deposition, and fibrinolysis during wound healing and adhesion formation is lacking. Therefore, there is a strong clinical need for a safe, multifunctional, and efficient anti-adhesion barrier system to effectively prevent abdominal adhesions without interfering wound healing. This project will utilize our innovative multifunctional hydrogels, previously established evidence regarding the inflammatory role of S100A9, and established rodent and porcine models to develop and assess new engineered systems. Our second generation hydrogel systems are based on the synthesis of multifunctional zwitterionic hydrogels and the incorporation of S100A9 inhibitor. These materials are envisioned to function as robust physical barriers, exhibit fouling-resistant properties, showcase anti-oxidative and anti-inflammatory characteristics, and possess the capability to accommodate therapeutic payloads. We also aim to gain an in- depth understanding of the role of S100A9 in the inflammatory milieu, peritoneal cell behavior, and immune cell recruitment during wound healing and adhesion formation. This proposal will build on the hypothesis that our zwitterionic hydrogels, with optimized zwitterionic moiety units and the incorporation of an S100A9 inhibitor, can effectively prevent postoperative abdominal adhesions in both rodent and porcine models. This will be examined in the following Specific Aims: 1) Develop multifunctional zwitterionic hydrogels and determine how the hydrogels with different zwitterionic functional groups affect postoperative abdominal adhesions; 2) Determine the roles of S100A9 on postoperative abdominal adhesions; and 3) Determine the efficacy of zwitterionic hydrogels in the prevention of postoperative abdominal adhesions in a porcine model. Current study will develop clinically applicable hydrogel systems for effectively preventing postoperative abdominal adhesions and will elucidate the role of S100A9 in regulating inflammation and peritoneal matrix remodeling during wound healing and adhesion formation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $597,290 )
2026	2026	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/4/2026	NEW	$597,290
														Subtotal = $597,290

Grand Total All Awards = $597,290

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Combining zwitterionic hydrogels with S100A9 inhibition for postoperative abdominal adhesion prevention

Award Number: R01DK149648

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/08/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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