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Pancreas regeneration in the conditions caused by genetic mutation

Award Number: R01DK148765
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/10/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Pancreas regeneration in the conditions caused by genetic mutation - Project summary/abstract Pancreatic diseases like pancreatitis and diabetes can cause serious health problems. But scientists still don’t fully understand how the pancreas heals itself after injury—especially in children or in people with genetic conditions like cystic fibrosis (CF). Most studies have looked at adults or focused only on the part of the pancreas that makes insulin. But the pancreas also helps with digestion by producing important proteins, and we know much less about how this part recovers after damage—especially in young people with CF. Our research team has created a new animal model that closely mimics how the pancreas gets injured and heals in people with a specific CF gene mutation. This model lets us turn the disease on and off, giving us a powerful way to study how healing happens. We’ve already seen that both the insulin-producing and digestive parts of the pancreas can bounce back if the underlying problem is fixed. In this project, we’ll explore how healing works in young versus adult animals, how some cells change their roles to help with repair, and whether recovery in one part of the pancreas can support healing in the other.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $718,880 )
2026	2026	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/7/2026	NEW	$718,880
														Subtotal = $718,880

Grand Total All Awards = $718,880

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Pancreas regeneration in the conditions caused by genetic mutation

Award Number: R01DK148765

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/10/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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