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Transforming Precision Medicine: Dynamic Learning and Prediction of Disease Progression in Massive, Diverse, and Multimodal Cohorts

Award Number: R01DK142026
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/10/2025
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Transforming Precision Medicine: Dynamic Learning and Prediction of Disease Progression in Massive, Diverse, and Multimodal Cohorts - Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Modern healthcare data, e.g., electronic medical records (EHRs) and biobanks, provide massive multi-level and multi-scale information over a long period. These datasets offer a unique opportunity to quantify disease progression and the associated time-varying risk factors. However, existing statistical algorithms and tools that can effectively analyze exposure trajectories and disease onset at this scale and complexity lag behind. This proposal aims to fill these gaps by delivering novel statistical methods, computational algorithms, and user-friendly software to study individual health trajectories relevant to disease onset and progression for biobank scale real-world data. It is motivated by our team’s recent experiences analyzing the UK Biobank, VA EHRs, NIH All of US, and other complex data sources. The proposed work will push forward several frontiers in biostatistics, optimization, and clinical medicine (i.e., personalized diabetes management, dynamic prediction, and early detection of disease progression).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $562,589 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	3/5/2026	NON-COMPETING CONTINUATION	$562,589
														Subtotal = $562,589

Issue Date FY: 2025 ( Subtotal = $562,589 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	5/16/2025	NEW	$35,687
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/7/2025	NEW	$526,902
														Subtotal = $562,589

Grand Total All Awards = $1,125,178

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Transforming Precision Medicine: Dynamic Learning and Prediction of Disease Progression in Massive, Diverse, and Multimodal Cohorts

Award Number: R01DK142026

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/10/2025

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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