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The Impact of Reflective Motivation on the Effect of a Shared Decision Making Intervention for Diabetes Prevention

Award Number: R01DK127733
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes (T2DM). Evidence from the Diabetes Prevention Program (DPP) indicates that lifestyle change and metformin use in this population are clinically equivalent, each reducing the incidence of T2DM by approximately 50%; women with a GDM history thus face a preference-sensitive decision between these evidence-based alternatives. Shared decision making (SDM) is an attractive approach for addressing the patients’ choice between two alternatives, using a decision aid to make the decision explicit, describe the available options with equipoise, elicit patient preferences, and helping patients make an informed decision that is right for them. To our knowledge, there are no existing studies evaluating SDM for diabetes prevention among women with a history of GDM. Moreover, understading mechanisms of action of such an intervention will contribute to our understanding of the “how, why and for whom” this intervention is effective, in turn improving our ability to harness behavior change strategies to improve outcomes for women at high risk for T2DM, and increasing knowledge of how to aid behavior adoption and maintenance during and after similar diabetes prevention interventions. Our team has extensive experience with a team-based SDM approach for diabetes prevention, and our prior work showed that this approach leads to increased uptake of an evidence-based diabetes prevention strategy and sustained weight loss at 12-month follow-up in a broader population with prediabetes. In this administrative supplement, we aim to use new and existing data collected in the parent R01 to evaluate components of reflective motivation, based on the Capability, Opportunity, Motivation, and Behavior (COM-B) model of behavior, as mediators and moderators of the SDM intervention for diabetes prevention among women with a history of GDM within two health systems (UCLA and Intermountain). Our Specific Aims are as follows: To test components of reflective motivation (perceived risk, perceived control [locus of control + self-efficacy]) as modifiers of the effectiveness of an SDM intervention for diabetes prevention on primary (weight loss at 12 months) and secondary (physical activity, eating patterns, treatment engagement) outcomes among overweight/obese women with a GDM history and hemoglobin A1c between 5.7-6.4% enrolled in the parent RCT; and To test components of reflective motivation (patient activation) as mediators of the effectiveness of an SDM intervention for diabetes prevention on primary and secondary outcomes among women enrolled in the parent RCT. Our application presents a unique opportunity to study mechanisms of a robust behavior change intervention in an existing rigorous project addressing a critical area of unmet need in diabetes prevention for women with history of GDM, leveraging our health system infrastructure and our collaborative, multidisciplinary team with a strong record of accomplishment in diabetes prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $497,600 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	11/28/2023	NON-COMPETING CONTINUATION	$497,600
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	12/5/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $497,600

Issue Date FY: 2023 ( Subtotal = $756,961 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	7/29/2023	SUPPLEMENT FOR EXPANSION	$193,004
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	1/20/2023	NON-COMPETING CONTINUATION	$563,957
														Subtotal = $756,961

Issue Date FY: 2022 ( Subtotal = $575,294 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	4/7/2022	NON-COMPETING CONTINUATION	$57,528
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	11/5/2021	NON-COMPETING CONTINUATION	$517,766
														Subtotal = $575,294

Issue Date FY: 2021 ( Subtotal = $589,875 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/15/2021	NEW	$589,875
														Subtotal = $589,875

Grand Total All Awards = $2,419,730

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The Impact of Reflective Motivation on the Effect of a Shared Decision Making Intervention for Diabetes Prevention

Award Number: R01DK127733

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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