Friday, July 26, 2024 7/26/2024

Mechanisms that Predict Weight Trajectory after Bariatric Surgery: The Interactive Roles of Behavior and Biology

Award Number: R01DK112585
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

Abstract Bariatric surgery is currently the most efficacious and durable intervention for severe obesity. Many comorbid conditions (e.g., diabetes, hypertension) generally remit or resolve following bariatric surgery. Yet, some patients experience suboptimal weight outcomes following surgery, often resulting from substantial weight regain following successful weight loss. Unfortunately, weight recidivism is also often associated with reemergence of obesity-associated comorbidities. The most commonly performed procedures in the U.S. are the Roux-en-Y Gastric Bypass (RYGB) and the laparoscopic Sleeve Gastrectomy (SG). Both procedures involve significant anatomical and physiological changes that lead to changes in behavior and biology. The etiological contributors to weight loss following surgery are not well understood, and it is therefore difficult to predict which patients may experience suboptimal post-surgical weight outcomes. Changes in eating and physical activity behaviors, mood, and the microbiome have all been reported to occur following bariatric surgery and have an association with weight change. Weight change likely involves complex interactions between behavioral and biological variables. The longitudinal relationship between changes in the gut microbiome and post-surgery weight trajectory has not been explored thoroughly, and the associations between the microbiome and other variables that impact weight have been similarly understudied. Therefore, we propose to conduct a prospective, 24-month longitudinal study of patients planning to undergo RYGB or SG and aim to identify correlates and predictors of observed weight loss trajectories over 24 months following bariatric surgery. In particular, this application is designed to examine the relationships between empirically supported behavioral and biological variables following surgery and their combined impact on weight outcome. These data will extend the current literature by collecting behavioral and biological data, by carrying out longer term follow-up of participants enrolled, and by studying a larger sample size. Novel data collection in this protocol will include intensive measurement of problematic eating behaviors and compliance with diet and exercise regimens post-surgically, which may be altered in parallel with, or in response to, changes observed in the gut microbiota. Identifying post-surgical predictors of weight loss and comorbidity resolution will allow for the development of interventions that can be tailored to individual patients based upon his/her risk profile which can then be implemented early to optimize surgery-related outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$79,914 )
2023	2020	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/1/2023	NON-COMPETING CONTINUATION	-$79,914
														Subtotal = -$79,914

Issue Date FY: 2020 ( Subtotal = $930,251 )
2020	2020	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	7/23/2020	NON-COMPETING CONTINUATION	$930,251
														Subtotal = $930,251

Issue Date FY: 2019 ( Subtotal = $956,003 )
2019	2019	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	8/16/2019	NON-COMPETING CONTINUATION	$956,003
														Subtotal = $956,003

Issue Date FY: 2018 ( Subtotal = $896,062 )
2018	2018	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	8/23/2018	NON-COMPETING CONTINUATION	$896,062
														Subtotal = $896,062

Issue Date FY: 2017 ( Subtotal = $963,151 )
2017	2017	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/7/2017	SUPPLEMENT FOR EXPANSION	$121,629
2017	2017	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	9/6/2017	NON-COMPETING CONTINUATION	$841,522
														Subtotal = $963,151

Issue Date FY: 2016 ( Subtotal = $803,943 )
2016	2016	NORTH DAKOTA STATE UNIVERSITY	P.O. BOX 5405	FARGO	ND	58105	CASS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/14/2016	NEW	$803,943
														Subtotal = $803,943

Grand Total All Awards = $4,469,496

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mechanisms that Predict Weight Trajectory after Bariatric Surgery: The Interactive Roles of Behavior and Biology

Award Number: R01DK112585

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer