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Competing Revision: Sensitization of the Reinforcing Value of Food as a Predictor of Weight Change in Adolescents.

Award Number: R01DK106265
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Competing Revision: Sensitization of the Reinforcing Value of Food as a Predictor of Weight Change in Adolescents. - Project Summary: The adolescent brain is driven to seek out reinforcers, but the areas of the brain involved in impulse control and executive function remain immature until early adulthood. This may make adolescents particularly susceptible to overeating and weight gain. Motivation to eat, or reinforcing value (RRV) of food, is a strong predictor of energy consumption and adiposity. Understanding factors that lead to higher levels of the RRV of food is a critical first step toward developing novel treatment and prevention strategies for obesity. The purpose of the parent grant was 1) to determine if increases in the RRV of high energy density snack foods predict weight gain over time 2) to determine if increases in the RRV of low energy density snacks protect against weight gain over time 3) to determine if RRV of physical activity and/or delay discounting (DD) moderate the relationship between changes in the RRV of food after repeated exposure and weight change in adolescents. We have completed baseline data collection on 95% of our target sample in the parent grant as well as follow-up appointments on approximately 50% of our target population. We have shown that children with healthy weight decrease their RRV of snack food after two weeks of repeated exposure, but children with overweight do not show changes in RRV of snack food after repeated exposure. We have also shown that participants who showed an increase in RRV of snack food after repeated exposure had significantly greater zBMI change at 6 and 15 months compared to those participants who did not increase their RRV of food. Finally, we showed that individuals with high baseline RRV and DD had significantly greater zBMI change at 6 and 15 months compared to those with low DD and RRV of food. When taken together, these findings suggest that several behavioral phenotypes predict zBMI change over time and could potentially help to identify individuals at high risk of weight gain prior to the onset of weight gain. While we work toward completion of the original goals of the parent grant, new ideas have emerged as we have progressed through this study. The primary purpose of this competing revision proposal is to build upon our preliminary findings and determine 1) if the predictive value of baseline behavioral phenotypes extends into later adolescence 2) the role that eating autonomy plays in eating behavior and weight change over time 3) the extent to which the development of disordered eating behavior and dieting moderates the relationship between baseline behavioral phenotypes and zBMI change over time. This competing revision proposal will enhance the value of the outcomes of the parent grant by adding additional, age-appropriate measures, by extending the timeline of our follow- up to later adolescence and emerging adulthood, and by allowing us to develop and validate a novel measure of eating behavior (eating autonomy) that may be particularly important during this critical period of eating behavior development. Once these factors are identified and characterized, future studies could focus on refining methods for altering the RRV of food as a way to increase healthy eating and decrease less healthy food intake.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1,400 )
2024	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	11/1/2023	SUPPLEMENT FOR EXPANSION	-$300
2024	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	11/1/2023	NON-COMPETING CONTINUATION	-$1,100
														Subtotal = -$1,400

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	1/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $459,462 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	3/6/2020	SUPPLEMENT FOR EXPANSION	$98,451
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	2/20/2020	NON-COMPETING CONTINUATION	$361,011
														Subtotal = $459,462

Issue Date FY: 2019 ( Subtotal = $361,287 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	3/27/2019	SUPPLEMENT FOR EXPANSION	$9,307
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	2/14/2019	NON-COMPETING CONTINUATION	$351,980
														Subtotal = $361,287

Issue Date FY: 2018 ( Subtotal = $352,250 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	4/19/2018	NON-COMPETING CONTINUATION	$35,225
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	2/1/2018	NON-COMPETING CONTINUATION	$317,025
														Subtotal = $352,250

Issue Date FY: 2017 ( Subtotal = $352,500 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	6/21/2017	NON-COMPETING CONTINUATION	$35,250
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/25/2017	NON-COMPETING CONTINUATION	$317,250
														Subtotal = $352,500

Issue Date FY: 2016 ( Subtotal = $352,745 )
2016	2016	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/11/2016	NEW	$352,745
														Subtotal = $352,745

Grand Total All Awards = $1,876,844

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Competing Revision: Sensitization of the Reinforcing Value of Food as a Predictor of Weight Change in Adolescents.

Award Number: R01DK106265

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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