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Brainstem circuits controlling gastrointestinal function

Award Number: R01DK055530
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Autonomic dysfunctions, especially gastrointestinal motility disorders, occur frequently in parkinsonian patients and are often prodromic to the clinical diagnosis of Parkinson’s disease (PD). Chronic constipation and delayed gastric emptying are observed in many parkinsonian patients and are especially troublesome; the latter provides an additional unresolved complication to the absorption and appropriate therapeutic dosing regimen of L-DOPA, i.e. the main therapy used to treat PD-related motor dysfunctions. In the quest to elucidate the treatment of parkinsonian-related gastroparesis, it is necessary to understand the factors, including the environmental influences, which contribute to the etiology and development of idiopathic PD. Several epidemiological studies have associated an increased incidence of PD with pesticide or herbicide exposure and rural location/lifestyle. Similarly, studies have indicated that vegetarians who follow a diet high in plant seed lectins have a higher incidence of PD compared to non-vegetarians. Of note, some vegetable cultivars in SE Asia have enriched lectin concentrations of up to 1%. Based on our preliminary studies that indicate impaired gastric motility upon administration of subthreshold doses of lectins and the herbicide paraquat, we propose the following novel hypothesis: “lectin- mediated retrograde transport of environmental toxins disrupts the brain-gut axis through a vagally-dependent ENS-DMV-SNpc pathway” prior to the development of PD-related motor dysfunctions. To investigate this novel hypothesis, we will use a combination of in vivo optogenetic, electrophysiological, anatomical and behavioral approaches in rodents to investigate on the gastric-related neural pathways affected in parkinsonian-related gastric dysfunctions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2020	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	11/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	6/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY AVE RM C1607	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	5/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY AVE RM C1607	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	1/22/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $393,892 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	6/16/2020	NON-COMPETING CONTINUATION	$393,892
														Subtotal = $393,892

Issue Date FY: 2019 ( Subtotal = $393,892 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	6/18/2019	NON-COMPETING CONTINUATION	$393,892
														Subtotal = $393,892

Issue Date FY: 2018 ( Subtotal = $393,892 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	6/6/2018	NON-COMPETING CONTINUATION	$393,892
														Subtotal = $393,892

Issue Date FY: 2017 ( Subtotal = $461,392 )
2017	2017	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	6/27/2017	COMPETING CONTINUATION	$461,392
														Subtotal = $461,392

Issue Date FY: 2012 ( Subtotal = $329,354 )
2012	2012	MILTON S HERSHEY MEDICAL CENTER	500 UNIVERSITY DRIVE, POB 850	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	4/24/2012	NON-COMPETING CONTINUATION	$329,354
														Subtotal = $329,354

Issue Date FY: 2011 ( Subtotal = $329,352 )
2011	2011	MILTON S HERSHEY MEDICAL CENTER	500 UNIVERSITY DRIVE, POB 850	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	6/8/2011	NON-COMPETING CONTINUATION	$329,352
														Subtotal = $329,352

Issue Date FY: 2010 ( Subtotal = $367,092 )
2010	2010	MILTON S HERSHEY MEDICAL CENTER	500 UNIVERSITY DRIVE, POB 850	HERSHEY	PA	17033	DAUPHIN	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	13	8/12/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$367,092
2010	2009	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	8/10/2010	COMPETING CONTINUATION	$0
														Subtotal = $367,092

Issue Date FY: 2009 ( Subtotal = $355,200 )
2009	2009	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	4/23/2009	COMPETING CONTINUATION	$355,200
														Subtotal = $355,200

Issue Date FY: 2006 ( Subtotal = $269,150 )
2006	2006	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Digestive Diseases and Nutrition Research	000	11	8/10/2006	NON-COMPETING CONTINUATION	$269,150
														Subtotal = $269,150

Issue Date FY: 2005 ( Subtotal = $275,626 )
2005	2005	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Digestive Diseases and Nutrition Research	000	10	8/29/2005	NON-COMPETING CONTINUATION	$275,626
														Subtotal = $275,626

Issue Date FY: 2004 ( Subtotal = $275,626 )
2004	2004	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Digestive Diseases and Nutrition Research	000	9	8/20/2004	NON-COMPETING CONTINUATION	$275,626
														Subtotal = $275,626

Issue Date FY: 2003 ( Subtotal = $346,415 )
2003	2003	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Digestive Diseases and Nutrition Research	000	7		COMPETING CONTINUATION	$346,415
														Subtotal = $346,415

Issue Date FY: 2002 ( Subtotal = $157,035 )
2002	2002	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Digestive Diseases and Nutrition Research	000	6	8/7/2002	NON-COMPETING CONTINUATION	$157,035
														Subtotal = $157,035

Issue Date FY: 2001 ( Subtotal = $152,593 )
2001	2001	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Digestive Diseases and Nutrition Research	000	5	9/17/2001	NON-COMPETING CONTINUATION	$152,593
														Subtotal = $152,593

Issue Date FY: 2000 ( Subtotal = $135,563 )
2000	2000	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Digestive Diseases and Nutrition Research	000	3	8/18/2000	NON-COMPETING CONTINUATION	$135,563
														Subtotal = $135,563

Issue Date FY: 1999 ( Subtotal = $131,703 )
1999	1999	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Digestive Diseases and Nutrition Research	000	2	9/16/1999	NON-COMPETING CONTINUATION	$131,703
														Subtotal = $131,703

Issue Date FY: 1998 ( Subtotal = $131,754 )
1998	1998	HENRY FORD HEALTH SYSTEM	2799 WEST GRAND BOULEVARD	DETROIT	MI	48202	WAYNE	USA	Digestive Diseases and Nutrition Research	000	1	9/3/1998	NEW	$131,754
														Subtotal = $131,754

Grand Total All Awards = $4,899,531

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Brainstem circuits controlling gastrointestinal function

Award Number: R01DK055530

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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