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Innovations in Shock Wave Lithotripsy Technology

Award Number: R01DK052985
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/1997
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Innovations in Shock Wave Lithotripsy Technology - SUMMARY ABSTRACT Urolithiasis imposes a substantial and growing public health burden in the United States with a prevalence nearly doubled over the past 15 years, impacting now 1 in 11 Americans in their lifetime. Shock wave lithotripsy (SWL) remains to be the only non-invasive treatment option for kidney stone patients despite the advances in ureteroscopy. The progressive decline in the clinic use of SWL, on the other hand, has been attributed to several key factors, including 1) no fundamental technology breakthrough with problematic dry coupling technique widely employed by contemporary shock wave lithotripters, 2) no real-time monitoring of cavitation activity during clinical SWL, and 3) increased number of shockwaves administered per session with elevated fragment size and non- successful rate. Overall, addressing these critical issues is urgently needed to improve the efficiency and safety of SWL, and ultimately, reinvigorate the confidence of urologists in this non-invasive treatment modality for stone patients. In this competing R01 renewal application, we will leverage the knowledge and expertise that our interdisciplinary team has accumulated in the past ten years through the R37 program. We will focus on developing the next-generation SWL, cavitation monitoring, and miniature wet coupling technologies as well as strategies to produce fine stone fragments in SWL with clear translational potentials. We propose three specific aims: 1) create a SAFE (Steerable and Adjustable Focusing Electrohydraulic) shock wave generator with flexible focal width and beam orientation, and a miniature wet coupling device, 2) develop 3D Dynamic Cavitation Monitoring (3D-DCM) technology for safeguarding SWL while improving stone fragmentation efficiency and treatment outcome , and 3) investigate mechanism of surface acoustic wave (SAW) generation and its contribution to producing fine fragments through synergistic interaction with cavitation in SWL. Achieving these aims will significantly advance the state-of-the-art research activities in SWL, and further propel technology development in the field in close collaboration with lithotripter manufacturers. The new technologies envisioned in this project will improve the safety and efficacy of SWL, while providing the urologist opportunity and flexibility in tailor-designing the treatment protocol for stone patients under various clinical scenarios.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $493,936 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	28	4/1/2025	NON-COMPETING CONTINUATION	$493,936
														Subtotal = $493,936

Issue Date FY: 2024 ( Subtotal = $524,986 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	27	6/4/2024	NON-COMPETING CONTINUATION	$524,986
														Subtotal = $524,986

Issue Date FY: 2023 ( Subtotal = $615,119 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	26	3/30/2023	NON-COMPETING CONTINUATION	$615,119
														Subtotal = $615,119

Issue Date FY: 2022 ( Subtotal = $726,720 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	25	3/4/2022	NON-COMPETING CONTINUATION	$573,996
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	25	3/31/2022	NON-COMPETING CONTINUATION	$63,780
2022	2021	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	24	10/30/2021	COMPETING CONTINUATION	$88,944
														Subtotal = $726,720

Issue Date FY: 2021 ( Subtotal = $584,864 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	24	4/29/2021	COMPETING CONTINUATION	$584,864
														Subtotal = $584,864

Issue Date FY: 2010 ( Subtotal = $129,897 )
2010	2010	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Recovery Act Research Support	000	13	11/19/2009	SUPPLEMENT FOR EXPANSION	$129,897
														Subtotal = $129,897

Issue Date FY: 2009 ( Subtotal = $304,315 )
2009	2009	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	8/24/2009	NON-COMPETING CONTINUATION	$304,315
														Subtotal = $304,315

Issue Date FY: 2008 ( Subtotal = $304,315 )
2008	2008	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	12	8/20/2008	NON-COMPETING CONTINUATION	$304,315
														Subtotal = $304,315

Issue Date FY: 2007 ( Subtotal = $310,526 )
2007	2007	DUKE UNIVERSITY	BOX 104135	DURHAM	NC	27708	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	11	8/21/2007	NON-COMPETING CONTINUATION	$310,526
														Subtotal = $310,526

Issue Date FY: 2006 ( Subtotal = $318,946 )
2006	2006	DUKE UNIVERSITY	POST OFFICE BOX 40005	DURHAM	NC	27706	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	10	8/3/2006	COMPETING CONTINUATION	$318,946
														Subtotal = $318,946

Issue Date FY: 2005 ( Subtotal = $329,175 )
2005	2005	DUKE UNIVERSITY	POST OFFICE BOX 40005	DURHAM	NC	27706	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	9	7/12/2005	NON-COMPETING CONTINUATION	$329,175
														Subtotal = $329,175

Issue Date FY: 2004 ( Subtotal = $329,175 )
2004	2004	DUKE UNIVERSITY	POST OFFICE BOX 40005	DURHAM	NC	27706	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	8	6/10/2004	NON-COMPETING CONTINUATION	$329,175
														Subtotal = $329,175

Issue Date FY: 2003 ( Subtotal = $380,765 )
2003	2003	DUKE UNIVERSITY	POST OFFICE BOX 40005	DURHAM	NC	27706	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	001	6		SUPPLEMENT FOR EXPANSION	$51,590
2003	2003	DUKE UNIVERSITY	POST OFFICE BOX 40005	DURHAM	NC	27706	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	7	8/18/2003	NON-COMPETING CONTINUATION	$329,175
														Subtotal = $380,765

Issue Date FY: 2002 ( Subtotal = $329,175 )
2002	2002	DUKE UNIVERSITY	POST OFFICE BOX 40005	DURHAM	NC	27706	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	6	7/26/2002	NON-COMPETING CONTINUATION	$329,175
														Subtotal = $329,175

Issue Date FY: 2001 ( Subtotal = $321,672 )
2001	2001	DUKE UNIVERSITY	POST OFFICE BOX 40005	DURHAM	NC	27706	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	5	9/19/2001	COMPETING CONTINUATION	$321,672
														Subtotal = $321,672

Issue Date FY: 2000 ( Subtotal = $183,455 )
2000	2000	Duke University	OFFICE OF SPONSORED PROGRAMS	DURHAM	NC	27705	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	4	8/25/2000	NON-COMPETING CONTINUATION	$183,455
														Subtotal = $183,455

Issue Date FY: 1999 ( Subtotal = $178,160 )
1999	1999	Duke University	OFFICE OF SPONSORED PROGRAMS	DURHAM	NC	27705	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	3	7/23/1999	NON-COMPETING CONTINUATION	$178,160
														Subtotal = $178,160

Issue Date FY: 1998 ( Subtotal = $173,026 )
1998	1998	Duke University	OFFICE OF SPONSORED PROGRAMS	DURHAM	NC	27705	DURHAM	USA	Kidney Diseases, Urology and Hematology Research	000	2	9/14/1998	NON-COMPETING CONTINUATION	$173,026
														Subtotal = $173,026

Grand Total All Awards = $6,538,227

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Innovations in Shock Wave Lithotripsy Technology

Award Number: R01DK052985

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/1997

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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