Sunday, October 6, 2024 10/6/2024

Quantitative Studies in Urinary Bladder Sensation

Award Number: R01DK051413
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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(PLEASE KEEP IN WORD, DO NOT PDF) ABSTRACT. Acute and chronic pains originating from the urinary bladder are common clinical entities affecting most females at some time in their lives, particularly as they get older. In an attempt to understand urinary bladder hypersensitivity in a translational manner, this ongoing research project has used rodents to define basic neurophysiological elements of bladder sensation at spinal and supraspinal levels. Using urinary bladder distension (UBD)-evoked reflexes and primary/spinal/supraspinal neuronal responses as experimental endpoints, clinically relevant models of bladder hypersensitivity have been developed. The present application explores the effect of aging on a rodent model of bladder pain that utilized neonatal bladder inflammation (NBI) to evoke many of the phenotypic features of interstitial cystitis/bladder pain syndrome (IC/BPS) with an emphasis on known alterations in opioidergic and corticotrophin releasing factor receptor (CRFR)-related modulatory mechanisms. Three Specific Aims are proposed: Specific Aim #1: To contrast/compare the effect of aging in rats which experienced neonatal bladder inflammation (NBI) and their controls on reflex and neuronal responses to urinary bladder distension (UBD) and bladder histology. Specific Aim #2: To contrast/compare the role of endogenous opioid systems modulating reflex & neuronal responses to UBD in both young adult and aged rats which experienced NBI and their controls. Specific Aim #3: To contrast/compare the role of spinal CRF systems modulating reflex & neuronal responses to UBD in both young adult and aged rats which experienced NBI and their controls. The proposed studies in rodent model systems will give insight related to bladder sensation and how it is altered by aging while exploring novel therapeutics. An improved understanding of sensory processing related to urinary bladder sensory pathways and their modulation by secondary insults will result in an increased translation of basic science to therapeutics for bladder pain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $285,120 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	22	8/26/2024	NON-COMPETING CONTINUATION	$285,120
2024	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	21	8/23/2024	COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	1/5/2024	COMPETING CONTINUATION	$69,486
2024	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	1/5/2024	NON-COMPETING CONTINUATION	-$69,486
														Subtotal = $285,120

Issue Date FY: 2023 ( Subtotal = $297,000 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	9/8/2023	COMPETING CONTINUATION	$297,000
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	8/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $297,000

Issue Date FY: 2022 ( Subtotal = $326,700 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	7/15/2022	NON-COMPETING CONTINUATION	$326,700
														Subtotal = $326,700

Issue Date FY: 2021 ( Subtotal = $326,700 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	6/30/2021	NON-COMPETING CONTINUATION	$326,700
														Subtotal = $326,700

Issue Date FY: 2020 ( Subtotal = $326,700 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	18	9/21/2020	COMPETING CONTINUATION	$952
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	7/3/2020	COMPETING CONTINUATION	$326,700
2020	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	17	9/21/2020	NON-COMPETING CONTINUATION	-$952
														Subtotal = $326,700

Issue Date FY: 2018 ( Subtotal = $330,750 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	3/22/2018	NON-COMPETING CONTINUATION	$297,675
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	17	5/14/2018	NON-COMPETING CONTINUATION	$33,075
														Subtotal = $330,750

Issue Date FY: 2017 ( Subtotal = $330,750 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	3/16/2017	NON-COMPETING CONTINUATION	$297,675
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	6/16/2017	NON-COMPETING CONTINUATION	$33,075
														Subtotal = $330,750

Issue Date FY: 2016 ( Subtotal = $330,750 )
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	3/17/2016	COMPETING CONTINUATION	$330,750
														Subtotal = $330,750

Issue Date FY: 2013 ( Subtotal = $212,059 )
2013	2013	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	7/29/2013	NON-COMPETING CONTINUATION	$212,059
														Subtotal = $212,059

Issue Date FY: 2012 ( Subtotal = $219,750 )
2012	2012	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	8/9/2012	NON-COMPETING CONTINUATION	$219,750
														Subtotal = $219,750

Issue Date FY: 2011 ( Subtotal = $219,750 )
2011	2011	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	9/8/2011	COMPETING CONTINUATION	$219,750
														Subtotal = $219,750

Issue Date FY: 2009 ( Subtotal = $16,687 )
2009	2009	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Recovery Act Research Support	000	11	7/17/2009	SUPPLEMENT FOR EXPANSION	$16,687
														Subtotal = $16,687

Issue Date FY: 2008 ( Subtotal = $291,305 )
2008	2008	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	11	2/27/2008	NON-COMPETING CONTINUATION	$291,305
														Subtotal = $291,305

Issue Date FY: 2007 ( Subtotal = $297,250 )
2007	2007	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	10	1/29/2007	COMPETING CONTINUATION	$297,250
														Subtotal = $297,250

Issue Date FY: 2005 ( Subtotal = $244,326 )
2005	2005	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	9	4/13/2005	NON-COMPETING CONTINUATION	$244,326
														Subtotal = $244,326

Issue Date FY: 2004 ( Subtotal = $244,326 )
2004	2004	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	8	4/2/2004	NON-COMPETING CONTINUATION	$244,326
														Subtotal = $244,326

Issue Date FY: 2003 ( Subtotal = $244,326 )
2003	2003	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	7	6/19/2003	NON-COMPETING CONTINUATION	$244,326
														Subtotal = $244,326

Issue Date FY: 2002 ( Subtotal = $331,494 )
2002	2002	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	6	6/3/2002	COMPETING CONTINUATION	$331,494
														Subtotal = $331,494

Issue Date FY: 2001 ( Subtotal = $116,608 )
2001	2001	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	5	6/6/2001	NON-COMPETING CONTINUATION	$116,608
														Subtotal = $116,608

Issue Date FY: 2000 ( Subtotal = $113,213 )
2000	2000	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	4	7/3/2000	NON-COMPETING CONTINUATION	$113,213
														Subtotal = $113,213

Issue Date FY: 1999 ( Subtotal = $109,912 )
1999	1999	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Kidney Diseases, Urology and Hematology Research	000	3	5/28/1999	NON-COMPETING CONTINUATION	$109,912
														Subtotal = $109,912

Grand Total All Awards = $5,322,187

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Quantitative Studies in Urinary Bladder Sensation

Award Number: R01DK051413

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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