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MicroRNA-Mediated Mechanisms in Temporomandibular Joint Health and Disease

Award Number: R01DE035223
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/05/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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MicroRNA-Mediated Mechanisms in Temporomandibular Joint Health and Disease - Abstract Oral health refers to the well-being of the mouth, including the teeth, gums, and joints, and is essential for orofacial functions such as speaking and chewing. The temporomandibular joint (TMJ), crucial for speaking, chewing, and swallowing, has a unique cartilage structure that supports both movement and growth. While TMJ osteoarthritis (TMJOA) affects 8-16% of the population, it remains significantly under-researched compared to knee osteoarthritis, which impacts 14% of U.S. adults. Treating TMJ diseases is particularly challenging due to the specialized nature of the mandibular condylar cartilage (MCC), a multi-layered structure that combines characteristics of both articular and growth plate cartilage. Understanding how this cartilage is regulated, along with strategies to restore damaged cartilage, is essential for developing effective treatments. This proposal aims to investigate the role of microRNAs, small non-coding RNAs that regulate gene expression, in maintaining TMJ health, specifically focusing on their regulation of fibrocartilage stem/progenitor cells (FCSCs) and the Hippo signaling pathway. These mechanisms are critical not only for the maintenance of healthy cartilage but also for the remoding of damaged cartilage. By exploring these processes, this study aims to fill the gap in TMJ research, offering potential breakthroughs in developing personalized treatment options and restoring cartilage integrity for TMJ disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $706,281 )
2026	2026	ADA FORSYTH INSTITUTE, INC.	100 CHESTNUT ST FL 4	SOMERVILLE	MA	02143	MIDDLESEX	USA	Oral Diseases and Disorders Research	000	1	5/11/2026	NEW	$706,281
														Subtotal = $706,281

Grand Total All Awards = $706,281

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MicroRNA-Mediated Mechanisms in Temporomandibular Joint Health and Disease

Award Number: R01DE035223

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/05/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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