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Role of the oral microbiome in driving local and systemic inflammation in HIV

Award Number: R01DE032624
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Role of the oral microbiome in driving local and systemic inflammation in HIV - PROJECT SUMMARY / ABSTRACT Chronic HIV infection remains a public health challenge with nearly 38 million people worldwide living with HIV/AIDS. Despite the success of antiretroviral therapy in suppressing ongoing viral replication, numerous challenges remain including chronic inflammation and accelerated onset of comorbidities. Better understanding of the mechanisms contributing to these phenomena is imperative to further reduce comorbidities and improve treatment of HIV. The microbiome is comprised of trillions of diverse microbes (bacterial, fungal, viral), and multiple lines of evidence highlight the connections between the microbiome, mucosal immune system, and HIV-related inflammation. While the intestinal microbiome has been the focus of intense research, less is known about the role of the oral microbiome in health and disease. In non-HIV settings, the oral microbiome has been associated with increased risk of inflammation-related comorbidities such as cardiovascular disease. Recent evidence has also highlighted the connection between the oral and gut microbiomes, and increased colonization of aerotolerant “oral” bacteria in the gut has been observed in many inflammatory diseases, including HIV. Studies examining the oral microbiome in the setting of HIV are limited, and none have examined the relationships between oral to gut bacteria translocation, onset of dysbiosis, and systemic inflammation in HIV. We hypothesize that bacterial translocation from the mouth to the gut contributes to the development of dysbiosis in chronic HIV infection. Further, we hypothesize that the oral microbiome contributes to local and systemic inflammation in chronic HIV, and this altered mucosal environment may increase susceptibility for oral infections. Using longitudinal specimens, novel saliva analyses, and epidemiologic clinical outcomes we will systematically address our hypotheses. We propose to: 1) determine the contribution of oral microbiota to gut dysbiosis and systemic inflammation in persons living with HIV; 2) define the relationship between salivary IgA responses to key oral bacteria and local and systemic inflammation; and 3) identify specific oral bacteria that may predict risk of oral sexually transmitted infections (STI) in at-risk persons with and without HIV. This work will help better define the complex relationships between the oral microbiome, inflammation, and infection susceptibility in HIV; a critical step for developing novel strategies and saliva-based monitoring tools to better treat HIV and reduce comorbidities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $758,545 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Oral Diseases and Disorders Research	000	3	6/23/2025	NON-COMPETING CONTINUATION	$758,545
														Subtotal = $758,545

Issue Date FY: 2024 ( Subtotal = $757,421 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Oral Diseases and Disorders Research	000	2	7/26/2024	NON-COMPETING CONTINUATION	$757,421
														Subtotal = $757,421

Issue Date FY: 2023 ( Subtotal = $761,604 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Oral Diseases and Disorders Research	000	1	7/27/2023	NEW	$723,524
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Oral Diseases and Disorders Research	001	1	8/29/2023	NEW	$38,080
														Subtotal = $761,604

Grand Total All Awards = $2,277,570

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Role of the oral microbiome in driving local and systemic inflammation in HIV

Award Number: R01DE032624

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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