Sunday, June 1, 2025 6/1/2025

Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

Award Number: R01DE031025
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy - SUMMARY Early childhood caries (ECC) is the most common chronic childhood disease. Although largely preventable, ECC affects one third of socioeconomically disadvantaged and racial/ethnic minority preschool children in the US. Effectively reducing ECC disparity requires a better understanding of its biological factors from birth to early childhood including identifying differential exposure to risk factors by race and socioeconomic status. While ECC is an infectious disease initiated by the oral microbiota (bacteria and fungi), the interplay between host, environment, and oral microbiota affects the onset and severity of ECC. However, to date, few studies have examined the early-life longitudinal development of oral microbiota in underserved children, and none have utilized comprehensive methods to examine multiplatform (host and environmental) factors that contribute to the establishment of cariogenic microflora and onset of ECC among the underserved children. Oral Microbiome in Early Infancy (OMEI) study will address this urgent need to understand biological factors related to ECC among underserved racial/ethnic minority groups. The OMEI leverages a recently archived birth cohort that compromises 160 low-income minority infants (primarily Black/African American) and a comprehensive collection of medical/oral health records and ~1760 salivary/supragingival samples (obtained via NIDCR KL2TR001999 and K23DE027412, PI: Xiao). The OMEI builds upon our previous work that 1) revealed racial background is associated with early-life oral microbiome development in the context of ECC; 2) demonstrated oral bacterial-fungal cross-kingdom interactions and their associations with ECC; 3) identified human genes related to Host-S. mutans-Dental caries interactions; and 4) developed machine-learning prediction models for ECC. In Aim 1, we will use metagenomic analysis to define the critical assembly and functional development of the oral microbiome (bacteria and fungi) in early infancy (birth to two years) among all infants and their respective racial groups. In Aim 2, we will use computational modeling to identify determinants (maternal, genetic, and immune factors) of infants’ oral microbiome development. In Aim 3, we will use high- dimensional statistical machine learning approaches to integrate multi-platform (maternal, microbial, genetic, immune, and environmental) data to identify biological factors underlying ECC etiopathogenesis and develop ECC prediction models. The OMEI will be the first study that examines the early-life biological factors underlying ECC disparity from an infants’ oral microbiome perspective. Risk factors revealed from OMEI could be used as targets for ECC early prediction and prevention specifically suitable for underserved children. An integrated health disparities research team with investigators from multiple disciplines (microbiome, perinatal oral health, metagenomic sequencing, high-dimensional biostatistics, genetics, and health disparities), together with an outstanding internal-external advisory committee, will ensure the success of the proposed OMEI project.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $683,122 )
2025	2025	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	000	4	2/14/2025	NON-COMPETING CONTINUATION	$614,812
2025	2025	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	001	4	5/6/2025	NON-COMPETING CONTINUATION	$68,310
														Subtotal = $683,122

Issue Date FY: 2024 ( Subtotal = $766,797 )
2024	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	003	3	7/10/2024	NON-COMPETING CONTINUATION	-$77,933
2024	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	001	3	1/25/2024	SUPPLEMENT FOR EXPANSION	$79,523
2024	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	000	3	1/24/2024	NON-COMPETING CONTINUATION	$631,169
2024	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Oral Diseases and Disorders Research	002	3	6/19/2024	NON-COMPETING CONTINUATION	$134,038
														Subtotal = $766,797

Issue Date FY: 2023 ( Subtotal = $896,275 )
2023	2023	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Oral Diseases and Disorders Research	001	2	1/23/2023	SUPPLEMENT FOR EXPANSION	$178,929
2023	2023	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Oral Diseases and Disorders Research	002	2	2/28/2023	NON-COMPETING CONTINUATION	$71,734
2023	2023	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Oral Diseases and Disorders Research	000	2	1/19/2023	NON-COMPETING CONTINUATION	$645,612
														Subtotal = $896,275

Issue Date FY: 2022 ( Subtotal = $844,221 )
2022	2022	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Oral Diseases and Disorders Research	001	1	8/24/2022	SUPPLEMENT FOR EXPANSION	$112,906
2022	2022	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Oral Diseases and Disorders Research	000	1	4/22/2022	NEW	$731,315
														Subtotal = $844,221

Grand Total All Awards = $3,190,415

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

Award Number: R01DE031025

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer