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Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic

Award Number: R01DE030413
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic - Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic ABSTRACT Controlled Differential Tooth Movement (CDTM) refers to the ability to move teeth to be displaced faster, or to minimize the movement of teeth to be stationary (i.e., anchorage teeth or teeth during the retention phase). CDTM is highly desired in common orthodontic treatments such as canine retraction, canine impaction, molar protraction, and space closure. Successful CDTM drastically shortens treatment time and reduces common side- effects such as root resorption and anchorage loss. Studies show that an intermittent vibration force (IVF) superimposed on orthodontic force accelerates tooth movement. Further, in the absence of orthodontic force, IVF strengthens bone mineral density of the alveolar bone. However, currently there is little evidence to facilitate optimal selection of stimulation level. Furthermore, lack of control on stimulation level on the target tooth inevitably results in inconsistent reporting of outcomes. The overarching goal of the proposed work is to enable CDTM in the clinic by transitioning from successful animal studies to clinical applications. Objectives of the proposed project include: 1) identifying optimal IVF stimulation level for accelerating orthodontic tooth movement in rats as well as associated side-effects; 2) verifying effects of IVF on bone strengthening resulting in tooth stabilization; and 3) determining the threshold that can be used to scale stimulation level up for larger species like dogs and humans. We hypothesize that: (H1) there is an optimal level of IVF that accelerates movement of targeted teeth without side-effects; (H2) the same IVF can strengthen the bone surrounding the tooth without orthodontic force and reduce relapse during retention; and (H3) stress in the periodontal ligament (PDL) can be used as the threshold to effectively scale up the stimulation level from rats to larger species for achieving accelerated tooth movement. These hypotheses will be tested through three specific aims. Aim 1: Determine the optimal level of IVF (OLIVF) stimulation superimposed on an orthodontic load system that accelerates tooth movement in a rat model (H1) and the associated biological responses. Aim 2: Determine the effects of OLIVF on the tooth without orthodontic force (H2). Aim 3: Scale up stimulation level for larger species including dogs and humans, by normalizing to stress in the PDL, and validate the theory on dogs (H3). A PDL stress threshold will be used as the criterion for scaling up IVF from rats to dogs in this proposed study, with an eye toward scaling up to humans in future studies. Thus, a novel method to ensure delivery of the specified IVF on each individual tooth in the clinic will also be tested. This comprehensive study will pave the way for clinical trials using this technology. Further, associated biomechanics and biological studies will elucidate the mechanism behind IVF based CDTM, which will further advance the field as well as methods for applying this technology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $406,528 )
2025	2025	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE # 1100	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Oral Diseases and Disorders Research	006	5	5/8/2025	NON-COMPETING CONTINUATION	$0
2025	2025	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE # 1100	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Oral Diseases and Disorders Research	002	5	3/18/2025	NON-COMPETING CONTINUATION	$406,528
2025	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Oral Diseases and Disorders Research	000	3	12/17/2024	NON-COMPETING CONTINUATION	-$441,321
2025	2024	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE # 1100	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Oral Diseases and Disorders Research	001	4	12/18/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$441,321
2025	2024	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE # 1100	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Oral Diseases and Disorders Research	005	4	3/19/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$215,662
2025	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Oral Diseases and Disorders Research	004	3	3/19/2025	NON-COMPETING CONTINUATION	-$1
2025	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Oral Diseases and Disorders Research	003	2	3/19/2025	NON-COMPETING CONTINUATION	-$215,661
														Subtotal = $406,528

Issue Date FY: 2024 ( Subtotal = $441,322 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Oral Diseases and Disorders Research	001	3	6/13/2024	NON-COMPETING CONTINUATION	$36,026
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Oral Diseases and Disorders Research	000	3	3/27/2024	NON-COMPETING CONTINUATION	$405,296
														Subtotal = $441,322

Issue Date FY: 2023 ( Subtotal = $454,006 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Oral Diseases and Disorders Research	000	2	3/23/2023	NON-COMPETING CONTINUATION	$454,006
														Subtotal = $454,006

Issue Date FY: 2022 ( Subtotal = $451,437 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Oral Diseases and Disorders Research	000	1	3/24/2022	NEW	$451,437
														Subtotal = $451,437

Grand Total All Awards = $1,753,293

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Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic

Award Number: R01DE030413

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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