Monday, November 3, 2025 11/3/2025

Diabetes-enhanced Experimental Periodontitis

Award Number: R01DE017732
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2007
PERIOD OF PERFORMANCE END DATE: 01/31/2027

Group Awards By:

View Award Description

Diabetes-enhanced Experimental Periodontitis - Abstract: Diabetes increases the risk and frequency of bacterial infection and alters the adaptive immune response. Surprisingly little is known about the impact of diabetes on dendritic cells and how it may increase susceptibility to periodontitis. The lack of understanding until recently has been hampered by limited technical ability to define the specific behavior of dendritic cells and interactions with other cell types during active periodontal disease. New advances in single cell transcriptomics such as single cell RNA-seq (scRNA-seq) have provided an exponential increase in our ability to dissect the behavior of specific cell types under various disease conditions. The studies proposed will elucidate how diabetes alters dendritic cell function in a way that contributes to periodontitis. New Prel Data has been added resulting a completely revised proposal demonstrating that diabetes alters dendritic cell gene expression in vivo as assessed by scRNA-seq. The studies proposed involve sophisticated bioinformatic analysis of scRNA-seq data very recently obtained and a new experimental approach, spatially resolved transcriptomics, to provide new insight on how diabetes may affect dendritic cell activity. The risk in this approach in Aim 1 is mitigated by Prel Data that have identified potential key genes that are up- or down-regulated in the periodontium in dendritic cells during active periodontal disease progression, which will be further investigated by bioinformatic analysis of scRNA-seq results. In addition, translational studies are proposed in Aim 1 as a preclinical step for therapeutic intervention. Functional studies are proposed in Aim 2 to examine gene candidates in vitro to establish cause and effect relationships between candidate genes and functional outcomes. Experiments in Aim 3 will use spatial transcriptomics to define how diabetes may alter the spatial compartments in which DC and other leukocytes are found during the initiation of periodontitis and investigate co-localization of cells and pattern of inflammatory gene expression to better understand their interaction. Taken together this proposal combines an unbiased approach for hypothesis discovery with functional in vitro and in vivo methods for hypothesis testing and establishing mechanisms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $459,116 )
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	15	5/6/2025	NON-COMPETING CONTINUATION	$45,912
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	15	1/17/2025	NON-COMPETING CONTINUATION	$413,204
														Subtotal = $459,116

Issue Date FY: 2024 ( Subtotal = $449,934 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	14	1/8/2024	NON-COMPETING CONTINUATION	$413,204
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	14	6/14/2024	NON-COMPETING CONTINUATION	$36,730
														Subtotal = $449,934

Issue Date FY: 2023 ( Subtotal = $461,436 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	13	2/22/2023	NON-COMPETING CONTINUATION	$46,144
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	13	1/25/2023	NON-COMPETING CONTINUATION	$415,292
														Subtotal = $461,436

Issue Date FY: 2022 ( Subtotal = $437,509 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	12	1/24/2022	COMPETING CONTINUATION	$437,509
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	002	12	6/9/2022	COMPETING CONTINUATION	$2,853
2022	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	11	6/9/2022	NON-COMPETING CONTINUATION	-$2,853
														Subtotal = $437,509

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	11	12/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $430,558 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	11	11/28/2018	NON-COMPETING CONTINUATION	$430,558
														Subtotal = $430,558

Issue Date FY: 2018 ( Subtotal = $438,940 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	10	11/15/2017	NON-COMPETING CONTINUATION	$395,046
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	10	4/20/2018	NON-COMPETING CONTINUATION	$43,894
														Subtotal = $438,940

Issue Date FY: 2017 ( Subtotal = $439,314 )
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	9	5/26/2017	NON-COMPETING CONTINUATION	$43,931
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	9	11/16/2016	NON-COMPETING CONTINUATION	$395,383
														Subtotal = $439,314

Issue Date FY: 2016 ( Subtotal = $451,681 )
2016	2016	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	8	12/15/2015	NON-COMPETING CONTINUATION	$406,513
2016	2016	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	8	1/29/2016	NON-COMPETING CONTINUATION	$45,168
														Subtotal = $451,681

Issue Date FY: 2015 ( Subtotal = $455,041 )
2015	2015	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	7	11/27/2014	COMPETING CONTINUATION	$455,041
														Subtotal = $455,041

Issue Date FY: 2011 ( Subtotal = $480,702 )
2011	2011	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	000	6	6/17/2011	NON-COMPETING CONTINUATION	$480,702
														Subtotal = $480,702

Issue Date FY: 2010 ( Subtotal = $490,276 )
2010	2010	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Oral Diseases and Disorders Research	001	5	9/7/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$461,155
2010	2010	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07107	ESSEX	USA	Oral Diseases and Disorders Research	000	4	4/20/2010	SUPPLEMENT FOR EXPANSION	$29,121
2010	2010	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07101	ESSEX	USA	Oral Diseases and Disorders Research	003	4	9/14/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2009	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07101	ESSEX	USA	Oral Diseases and Disorders Research	002	4	9/14/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $490,276

Issue Date FY: 2009 ( Subtotal = $407,568 )
2009	2009	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07107	ESSEX	USA	Oral Diseases and Disorders Research	002	4	6/26/2009	NON-COMPETING CONTINUATION	$308,568
2009	2009	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07107	ESSEX	USA	Trans-NIH Recovery Act Research Support	003	4	9/16/2009	SUPPLEMENT FOR EXPANSION	$99,000
2009	2008	BOSTON UNIVERSITY	25 BUICK ST	BOSTON	MA	02215	SUFFOLK	USA	Oral Diseases and Disorders Research	000	2	2/6/2009	NON-COMPETING CONTINUATION	-$183,977
2009	2008	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07107	ESSEX	USA	Oral Diseases and Disorders Research	001	3	2/6/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$183,977
														Subtotal = $407,568

Issue Date FY: 2008 ( Subtotal = $321,425 )
2008	2008	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Oral Diseases and Disorders Research	000	2	6/11/2008	NON-COMPETING CONTINUATION	$321,425
														Subtotal = $321,425

Issue Date FY: 2007 ( Subtotal = $325,000 )
2007	2007	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Oral Diseases and Disorders Research	000	1	6/26/2007	NEW	$325,000
														Subtotal = $325,000

Grand Total All Awards = $6,048,500

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Diabetes-enhanced Experimental Periodontitis

Award Number: R01DE017732

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2007

PERIOD OF PERFORMANCE END DATE: 01/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer