Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS

Award Number: R01DE014190
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2003
PERIOD OF PERFORMANCE END DATE: 03/31/2009

Group Awards By:

View Award Description

DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS - DESCRIPTION (provided by applicant): The need for biomaterials has increased as the world population ages. Calcium phosphate cements (CPC) are highly promising for wide clinical applications due to their osteoconductivity and bone replacement capability.Their low strength, however, limits CPC to only non-stress uses. A literature search revealed no study on fiber reinforcement of CPC. In preliminary studies, the promise for CPC reinforcement was shown with a 2- to 5-fold increase in strength, 6-fold increase in fracture toughness, and two orders of magnitude increase in work-of-fracture. In this project, Aim 1 will use absorbable fibers to strengthen CPC and then to dissolve and create microprocessor vascular ingrowth; the effects of fiber length, volume fraction and fiber-matrix interface will be studied. Aim 2vill study the effects of changes in the absorbable fiber properties on the composite properties, and establish predictive equations. In Aim 3, CPC matrices with wide property ranges will be used to establish the relationships between matrix and composite properties. Non-rigid CPC, fast-dissolution CPC, flow able CPC and macroporous CPC will be studied; models on fundamental structure-property relationships will be determined. Aim 4 will investigate novel methods to control the macropore formation rate and tailor the strength history of the implant. Faster-absorbable fibers and slow-absorbable fibers will be combined in CPC for a high initial strength. Then the faster fibers dissolve and create macropores for bony ingrowth, while the slow fibers provide longer-term strength. Modeling will be performed to relate the composite property change to that of each fiber. In Aim 5, absorbable meshes will be used in CPC for strength and then highly interconnected macropores. The effects of mesh thickness and strength changes in immersion will be investigated and predictive equations will be established. Functionally graded multilayer implants will be investigated using mesh and fibers for controlled strength and macropore formation gradient. These studies will: 1) Yield novel composites for Dental and craniofacial repairs with superior strength, self-setting ability, scaffold structures, and capability of resorption and replacement by new bone; (it) Establish microstructural design methods for implants to achieve high strength and toughness with tailored strength history and macropore formation rates; (iii) Provide new reinforcement mechanisms, fundamental composite-constituent relationships, predictive models, and processing guidance to form the basis for a new generation of biomaterials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2013	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	11	12/8/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $441,674 )
2013	2013	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	001	11	5/10/2013	NON-COMPETING CONTINUATION	$27,602
2013	2013	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	11	11/28/2012	NON-COMPETING CONTINUATION	$414,072
														Subtotal = $441,674

Issue Date FY: 2012 ( Subtotal = $277,104 )
2012	2012	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	10	12/21/2011	NON-COMPETING CONTINUATION	$249,396
2012	2012	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	001	10	1/25/2012	NON-COMPETING CONTINUATION	$27,708
														Subtotal = $277,104

Issue Date FY: 2011 ( Subtotal = $273,027 )
2011	2011	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	9	12/27/2010	NON-COMPETING CONTINUATION	$255,652
2011	2011	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	001	9	5/31/2011	NON-COMPETING CONTINUATION	$17,375
														Subtotal = $273,027

Issue Date FY: 2010 ( Subtotal = $701,120 )
2010	2010	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	002	8	1/12/2010	NON-COMPETING CONTINUATION	$43,110
2010	2010	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	8	12/8/2009	NON-COMPETING CONTINUATION	$431,111
2010	2009	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Trans-NIH Recovery Act Research Support	003	7	3/18/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2009	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Trans-NIH Recovery Act Research Support	001	7	1/4/2010	SUPPLEMENT FOR EXPANSION	$226,899
														Subtotal = $701,120

Issue Date FY: 2009 ( Subtotal = $462,985 )
2009	2009	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Trans-NIH Recovery Act Research Support	002	7	9/21/2009	SUPPLEMENT FOR EXPANSION	$189,725
2009	2009	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	001	7	6/26/2009	COMPETING CONTINUATION	$0
2009	2009	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Oral Diseases and Disorders Research	000	7	3/20/2009	COMPETING CONTINUATION	$273,260
														Subtotal = $462,985

Issue Date FY: 2007 ( Subtotal = $248,898 )
2007	2007	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	5	3/16/2007	NON-COMPETING CONTINUATION	$248,898
														Subtotal = $248,898

Issue Date FY: 2006 ( Subtotal = $256,332 )
2006	2006	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	4	3/21/2006	NON-COMPETING CONTINUATION	$256,332
														Subtotal = $256,332

Issue Date FY: 2005 ( Subtotal = $262,500 )
2005	2005	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	3	3/29/2005	NON-COMPETING CONTINUATION	$262,500
														Subtotal = $262,500

Issue Date FY: 2004 ( Subtotal = $225,000 )
2004	2004	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	2	3/5/2004	NON-COMPETING CONTINUATION	$225,000
														Subtotal = $225,000

Issue Date FY: 2003 ( Subtotal = $225,000 )
2003	2003	AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION	211 EAST CHICAGO AVE	CHICAGO	IL	60611	COOK	USA	Oral Diseases and Disorders Research	000	1		NEW	$225,000
														Subtotal = $225,000

Grand Total All Awards = $3,373,640

Top

All Categories

About

Search

Reports

Data Submission

Award Information

DEVELOPMENT OF STRONG AND MACROPOROUS BIOMATERIALS

Award Number: R01DE014190

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2003

PERIOD OF PERFORMANCE END DATE: 03/31/2009

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer