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Differential Control of Auditory Cortex by Two Populations of Layer 1 Interneurons

Award Number: R01DC018353
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary. The primary auditory cortex (A1) is a central site of convergence for ascending sensory projections and projections from diverse neuromodulatory regions. These inputs interact in A1 to both influence moment-to-moment cortical activity and drive long-lasting changes in synaptic connections that may underlie auditory behavioral learning. Our recent work has revealed that a diverse group of inhibitory interneurons in cortical layer 1 (L1) has a privileged capacity to integrate tuned sensory input from the auditory thalamus and neuromodulatory inputs from cholinergic and serotonergic brain regions. These L1 interneurons send spatially- precise axonal projections to their postsynaptic targets that powerfully control cortical network activity and plasticity. Our recent results suggest that two distinct classes of L1 interneurons defined by the expression of either neuron-derived neurotrophic factor (NDNF) or vasoactive intestinal peptide (VIP) may receive differential inputs and send distinct outputs to their cortical targets. We propose that each L1 interneuron class has a specialized function in controlling cortical activity and plasticity. However, the mechanisms by which NDNF and VIP L1 interneuron subtypes are activated and control cortical state and plasticity are not fully understood. To address this unknown, we will use anatomical, trans-synaptic viral tracing, and electrophysiological approaches to elucidate the pre and post-synaptic partners of NDNF and VIP L1 interneurons in mouse A1. We will also use two-photon imaging in behaving mice to determine the in vivo activity and plasticity of NDNF and VIP L1 interneurons during auditory perceptual learning. The results of this research will identify L1 circuit mechanisms that promote auditory plasticity in adulthood and can be exploited to advance treatments following hearing loss.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $512,062 )
2024	2024	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	11/16/2023	NON-COMPETING CONTINUATION	$460,856
2024	2024	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	5	5/2/2024	NON-COMPETING CONTINUATION	$51,206
														Subtotal = $512,062

Issue Date FY: 2023 ( Subtotal = $631,014 )
2023	2023	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	4	8/11/2023	SUPPLEMENT FOR EXPANSION	$118,952
2023	2023	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	4	11/16/2022	NON-COMPETING CONTINUATION	$460,856
2023	2023	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	4	1/14/2023	NON-COMPETING CONTINUATION	$51,206
														Subtotal = $631,014

Issue Date FY: 2022 ( Subtotal = $512,062 )
2022	2022	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	3	11/22/2021	NON-COMPETING CONTINUATION	$460,856
2022	2022	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	3	4/22/2022	NON-COMPETING CONTINUATION	$51,206
														Subtotal = $512,062

Issue Date FY: 2021 ( Subtotal = $512,062 )
2021	2021	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	2	1/8/2021	NON-COMPETING CONTINUATION	$51,206
2021	2021	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	2	10/27/2020	NON-COMPETING CONTINUATION	$460,856
														Subtotal = $512,062

Issue Date FY: 2020 ( Subtotal = $512,062 )
2020	2020	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	1	11/20/2019	NEW	$512,062
														Subtotal = $512,062

Grand Total All Awards = $2,679,262

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Differential Control of Auditory Cortex by Two Populations of Layer 1 Interneurons

Award Number: R01DC018353

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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