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Heterogeneity of mitral cell properties determined by the timing of neurogenesis

Award Number: R01DC016307
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT We have an ability to discriminate between millions of odors. Each odorant binds to subsets of olfactory sensory neurons, which subsequently activate specific glomeruli in the olfactory bulb (OB). In the glomeruli, mitral and tufted cells, OB projection neurons, receive synaptic inputs from the olfactory sensory neurons. Mitral/tufted cells are the only neurons that transmit olfactory information to the olfactory cortex. To process the vast amount of information from the olfactory sensory neurons, OB projection neurons consist of functionally different subpopulations. Over the past several decades, differences between mitral and tufted cells have been intensively studied. Moreover, several lines of recent evidence show that we cannot consider mitral cells as a homogeneous population anymore. However, the most fundamental aspects of mitral cell heterogeneity are still unknown: How many mitral cell subpopulations? What factor(s) determines the mitral cell properties? Are there correlations among different mitral cell properties? What are the roles of each mitral cell subpopulation in olfactory information processing? As a starting point to address these significant gaps in our knowledge, we previously demonstrated that mitral cells generated at different timing during development were incorporated into functionally distinct neuronal circuits in the OB, suggesting that we can sort the mitral cells into functionally different subgroups based on their timing of neurogenesis (“neuronal birthdate”). In this project, we will separately label the early- and late-generated mitral cells with fluorescent proteins using an innovative method developed by the PI; in utero electroporation of plasmid vectors. Using this technique, we will determine whether mitral cells with different neuronal birthdates play different roles in olfactory information processing by pursuing following three specific aims: Specific Aim 1) Determine whether the molecular expression profile of mitral cells varies based on their timing of neurogenesis; Specific Aim 2) Characterize the functional properties of early- and late-generated mitral cells; and Specific Aim 3) Examine whether early- and late-generated mitral cells differentially project axons to the olfactory cortex. The proposed project will advance our knowledge about rule(s) used for olfactory information processing in the OB and the olfactory cortex.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$124 )
2025	2021	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	001	4	11/7/2024	SUPPLEMENT FOR EXPANSION	-$69
2025	2021	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	000	5	11/7/2024	NON-COMPETING CONTINUATION	-$55
														Subtotal = -$124

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	000	5	4/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $738,122 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY AVE RM C1607	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	000	4	4/9/2021	SUPPLEMENT FOR EXPANSION	$408,829
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY AVE RM C1607	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	001	5	6/7/2021	NON-COMPETING CONTINUATION	$329,293
														Subtotal = $738,122

Issue Date FY: 2020 ( Subtotal = $329,293 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	000	4	6/23/2020	NON-COMPETING CONTINUATION	$329,293
														Subtotal = $329,293

Issue Date FY: 2019 ( Subtotal = $329,293 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	000	3	6/14/2019	NON-COMPETING CONTINUATION	$329,293
														Subtotal = $329,293

Issue Date FY: 2018 ( Subtotal = $329,293 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	000	2	6/8/2018	NON-COMPETING CONTINUATION	$329,293
														Subtotal = $329,293

Issue Date FY: 2017 ( Subtotal = $336,873 )
2017	2017	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	Research Related to Deafness and Communication Disorders	000	1	6/16/2017	NEW	$336,873
														Subtotal = $336,873

Grand Total All Awards = $2,062,750

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Heterogeneity of mitral cell properties determined by the timing of neurogenesis

Award Number: R01DC016307

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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