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The Efficacy of a Visualizing Reading Intervention on Improving the Brain's Reading Network in Children with Autism

Award Number: R01DC016303
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT The overarching goal of this proposal is to test the impact of a comprehensive reading intervention program on changing the neurobiological mechanisms underlying reading comprehension deficits in children with autism spectrum disorders (ASD). There is evidence that as many as 65% of children with ASD have a deficit in reading comprehension. This ultimately has profound impact on language, learning, and academic success (Nation, Clarke, Wright, & Williams, 2006). Poor reading comprehension in children with autism is often masked by their relative strength in decoding. Moreover, reading comprehension in general is not well- understood, and as a result, current treatments are limited in its potential and in its effectiveness. In this project, we will test a group of children with ASD and NT control participants who share common characteristic of average level decoding along with below average reading comprehension. We also have included an additional NT group without any reading comprehension deficits, and this group will serve as another control for additional comparisons. We will test the efficacy of an intensive reading intervention training program, visualizing and verbalizing for language comprehension and thinking (V/V), and its effects on changing the brain circuitry underlying reading comprehension in children with ASD. The project will use multimodal neuroimaging with task-based functional MRI, resting state functional MRI, diffusion imaging, and neuropsychological testing. It should be noted that neuroimaging as well as behavioral studies of language in autism have largely ignored a subgroup of children with comprehension deficits. The proposed project addresses this critical gap by targeting brain plasticity in children with ASD (age: 7-13 years). Average decoding ability with below average comprehension of language in children is an important problem of academic and public health significance. The outcome of this study will throw more light on this important subgroup of children. In addition, it will test the efficacy of an intervention that can, in the long-run, help NT and disabled children with reading problems to achieve academic success. Findings may provide important preliminary steps in using V/V intervention in schools.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF ALABAMA	301 ROSE ADMIN BLDG	TUSCALOOSA	AL	35487	TUSCALOOSA	USA	Research Related to Deafness and Communication Disorders	000	6	11/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $525,569 )
2022	2022	UNIVERSITY OF ALABAMA	301 ROSE ADMIN BLDG	TUSCALOOSA	AL	35487	TUSCALOOSA	USA	Research Related to Deafness and Communication Disorders	000	6	8/25/2022	NON-COMPETING CONTINUATION	$525,569
														Subtotal = $525,569

Issue Date FY: 2021 ( Subtotal = $534,333 )
2021	2021	UNIVERSITY OF ALABAMA	301 ROSE ADMIN BLDG	TUSCALOOSA	AL	35487	TUSCALOOSA	USA	Research Related to Deafness and Communication Disorders	000	5	8/10/2021	NON-COMPETING CONTINUATION	$534,333
														Subtotal = $534,333

Issue Date FY: 2020 ( Subtotal = $555,824 )
2020	2020	UNIVERSITY OF ALABAMA	301 ROSE ADMIN BLDG	TUSCALOOSA	AL	35487	TUSCALOOSA	USA	Research Related to Deafness and Communication Disorders	005	4	8/11/2020	NON-COMPETING CONTINUATION	$546,359
2020	2019	UNIVERSITY OF ALABAMA	301 ROSE ADMIN BLDG	TUSCALOOSA	AL	35487	TUSCALOOSA	USA	Research Related to Deafness and Communication Disorders	004	3	5/4/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$328,698
2020	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	003	2	5/4/2020	NON-COMPETING CONTINUATION	-$898
2020	2019	UNIVERSITY OF ALABAMA	301 ROSE ADMIN BLDG	TUSCALOOSA	AL	35487	TUSCALOOSA	USA	Research Related to Deafness and Communication Disorders	001	3	11/19/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$563,746
2020	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	2	11/18/2019	NON-COMPETING CONTINUATION	-$554,281
2020	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	002	1	5/4/2020	NEW	-$327,800
														Subtotal = $555,824

Issue Date FY: 2019 ( Subtotal = $555,179 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	2	8/27/2019	NON-COMPETING CONTINUATION	$555,179
2019	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	1	2/26/2019	NEW	$0
														Subtotal = $555,179

Issue Date FY: 2018 ( Subtotal = $564,897 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	1	8/21/2018	NEW	$564,897
														Subtotal = $564,897

Grand Total All Awards = $2,735,802

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The Efficacy of a Visualizing Reading Intervention on Improving the Brain's Reading Network in Children with Autism

Award Number: R01DC016303

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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