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Sensorimotor integration in the auditory dorsal stream

Award Number: R01DC014989
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2015
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Sensorimotor integration in the auditory dorsal stream - Project Summary/Abstract Two cortical pathways originate from early core and belt areas of auditory cortex: a ventral pathway subserving identification of sounds, and a dorsal pathway that was originally defined – similar to the visual system – as a processing stream for space and motion. It has been proposed that the auditory dorsal pathway should be reframed in a wider sense as a processing stream for sensorimotor integration and control (Rauschecker, 2011). This broader function explicitly includes spatial processing but also extends to the processing of auditory-motor sequences, including spoken speech and musical melodies in humans. In this long-term project, we will test the expanded model of the auditory dorsal stream by training rhesus monkeys to produce sound sequences on a new behavioral apparatus (“monkey piano”) developed in our laboratory (Archakov et al., 2020). By pressing a lever, the monkey produces a tone of a specific pitch; by pressing several levers in succession, the monkey produces a melody. After an animal has learned to reliably play the same sequence, auditory-responsive brain regions are identified through whole-brain functional magnetic resonance imaging (fMRI) while the animal is alert and listens to the learned self-produced sequence. Control stimuli include melodies the monkey has been passively exposed to, and novel melodies that the monkey has never heard before. Results from the previous funding cycle show that listening to the self-produced melody activates not only auditory areas but also motor regions of the brain, thus demonstrating the existence of internal models linking perception and action. The locations of activated regions will now guide electrophysiological recording with linear microelectrode arrays (LMAs). We will record neuronal responses in auditory and motor regions of cortex to passive listening of the sound sequences and compare them to neuronal activity obtained when the monkey actively produces the sequence with and without sound. Finally, we will add video of a monkey playing the sound sequence on the monkey piano and study multisensory interactions along the dorsal stream using fMRI and LMAs. In particular, responses in caudal auditory belt and parabelt will be compared with those in premotor cortex and posterior parietal cortex in simultaneous recordings. Our studies, using alert monkeys trained in a behavioral task, will contribute to the understanding of unified principles of perception and cognition across sensory systems and their interactions with the motor system in the form of internal models. Investigating the auditory dorsal stream in a nonhuman primate will provide essential information on the origin of human communication, including speech and music. Our studies are relevant for higher–level processing disorders of speech and its production, such as apraxia of speech, non-fluent aphasia, and specific language disorders that involve inadequate coordination between sensory and motor systems. The results will also improve our understanding of sensorimotor disorders, such as ataxia, which may be caused by stroke or neurodegenerative disease, thus leading to better therapies and rehabilitation strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	10	3/4/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $393,945 )
2025	2025	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	10	5/7/2025	NON-COMPETING CONTINUATION	$393,945
														Subtotal = $393,945

Issue Date FY: 2024 ( Subtotal = $393,945 )
2024	2024	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	9	5/15/2024	NON-COMPETING CONTINUATION	$393,945
														Subtotal = $393,945

Issue Date FY: 2023 ( Subtotal = $420,465 )
2023	2023	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	8	6/21/2023	NON-COMPETING CONTINUATION	$420,465
														Subtotal = $420,465

Issue Date FY: 2022 ( Subtotal = $420,465 )
2022	2022	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	7	7/25/2022	NON-COMPETING CONTINUATION	$420,465
2022	2021	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	002	6	8/18/2022	COMPETING CONTINUATION	$67,063
2022	2020	GEORGETOWN UNIVERSITY	MAIN CAMPUS	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	001	5	8/18/2022	SUPPLEMENT FOR EXPANSION	-$67,063
														Subtotal = $420,465

Issue Date FY: 2021 ( Subtotal = $517,508 )
2021	2021	GEORGETOWN UNIVERSITY (THE)	37TH AND O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	001	6	5/31/2021	COMPETING CONTINUATION	$517,508
2021	2020	GEORGETOWN UNIVERSITY (THE)	37TH AND O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	5	5/31/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $517,508

Issue Date FY: 2020 ( Subtotal = $475,889 )
2020	2020	GEORGETOWN UNIVERSITY (THE)	37TH AND O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	002	5	7/3/2020	SUPPLEMENT FOR EXPANSION	$77,824
2020	2020	GEORGETOWN UNIVERSITY (THE)	37TH & O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	5	11/21/2019	NON-COMPETING CONTINUATION	$358,259
2020	2020	GEORGETOWN UNIVERSITY (THE)	37TH & O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	001	5	1/15/2020	NON-COMPETING CONTINUATION	$39,806
														Subtotal = $475,889

Issue Date FY: 2019 ( Subtotal = $442,714 )
2019	2019	GEORGETOWN UNIVERSITY (THE)	37TH & O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	4	11/14/2018	NON-COMPETING CONTINUATION	$442,714
														Subtotal = $442,714

Issue Date FY: 2018 ( Subtotal = $539,317 )
2018	2018	GEORGETOWN UNIVERSITY (THE)	37TH & O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	001	3	4/3/2018	NON-COMPETING CONTINUATION	$53,933
2018	2018	GEORGETOWN UNIVERSITY (THE)	37TH & O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	3	11/14/2017	NON-COMPETING CONTINUATION	$485,384
														Subtotal = $539,317

Issue Date FY: 2017 ( Subtotal = $531,759 )
2017	2017	GEORGETOWN UNIVERSITY (THE)	37TH & O ST NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	001	2	5/24/2017	NON-COMPETING CONTINUATION	$53,176
2017	2017	GEORGETOWN UNIVERSITY (THE)	37TH & O STS NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	2	11/2/2016	NON-COMPETING CONTINUATION	$478,583
														Subtotal = $531,759

Issue Date FY: 2016 ( Subtotal = $530,826 )
2016	2016	GEORGETOWN UNIVERSITY	37TH & O STREETS, NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	001	1	11/12/2015	NEW	$0
2016	2016	GEORGETOWN UNIVERSITY	37TH & O STREETS, NW	WASHINGTON	DC	20057	DISTRICT OF COLUMBIA	USA	Research Related to Deafness and Communication Disorders	000	1	11/10/2015	NEW	$530,826
														Subtotal = $530,826

Grand Total All Awards = $4,666,833

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Sensorimotor integration in the auditory dorsal stream

Award Number: R01DC014989

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2015

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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