Thursday, November 21, 2024 11/21/2024

Targeting of sensory axons in the olfactory bulb

Award Number: R01DC012854
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT The objective of this proposal is to understand how the first elements of olfactory circuitry are correctly wired together during embryonic development. Odorant sensing neurons project axons from the olfactory epithelium to the olfactory bulb in the brain. Each olfactory sensory neuron in the epithelium chooses a single odorant receptor to express from a very large gene repertoire. Remarkably, all the sensory neurons that have chosen the same odorant receptor to express extend axons that converge together in specific reproducible locations within the olfactory bulb. This research proposal addresses how olfactory sensory axons locate their specific targets in the brain. This project takes advantage of the relative simplicity of the zebrafish olfactory system and its developmental and experimental accessibility to study the guidance of sensory neurons between the olfactory epithelium and the bulb. In the first Aim, single cell RNA sequencing is used to identify cell surface or secreted proteins that are differentially expressed between groups of olfactory sensory neurons whose axons target different and distinct regions in the olfactory bulb. These are candidate genes involved in targeting, and their function will be assessed by knocking them down one at a time and testing whether OSN axons target their correct locations in the olfactory bulb. In the second Aim, we will examine the role an important family of axon guidance cues, the slits, play in directing olfactory sensory axons to their appropriate target regions in the bulb. These studies build towards a systems level understanding of how an important functional circuit is assembled during development. This knowledge will be essential in the formulation of therapies for the regeneration and repair of olfactory circuitry in aging or anosmic patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	11	10/10/2024	COMPETING CONTINUATION	$0
2025	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	10	10/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $501,127 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	11	6/5/2024	COMPETING CONTINUATION	$501,127
2024	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	10	6/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $501,127

Issue Date FY: 2022 ( Subtotal = $489,639 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	10	6/22/2022	NON-COMPETING CONTINUATION	$489,639
														Subtotal = $489,639

Issue Date FY: 2021 ( Subtotal = $604,183 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	9	6/18/2021	SUPPLEMENT FOR EXPANSION	$105,673
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	9	5/18/2021	NON-COMPETING CONTINUATION	$489,639
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	9	5/20/2021	SUPPLEMENT FOR EXPANSION	$8,871
														Subtotal = $604,183

Issue Date FY: 2020 ( Subtotal = $596,047 )
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	8	5/22/2020	NON-COMPETING CONTINUATION	$596,047
														Subtotal = $596,047

Issue Date FY: 2019 ( Subtotal = $587,179 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	003	7	7/25/2019	SUPPLEMENT FOR EXPANSION	$97,540
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	7	6/8/2019	NON-COMPETING CONTINUATION	$489,639
2019	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	6	11/30/2018	COMPETING CONTINUATION	$137,030
2019	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	5	11/30/2018	NON-COMPETING CONTINUATION	-$137,030
														Subtotal = $587,179

Issue Date FY: 2018 ( Subtotal = $505,316 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	6	6/27/2018	COMPETING CONTINUATION	$505,316
														Subtotal = $505,316

Issue Date FY: 2017 ( Subtotal = $431,835 )
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	002	5	6/16/2017	NON-COMPETING CONTINUATION	$431,835
2017	2016	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	001	4	11/8/2016	EXTENSION WITH OR WITHOUT FUNDS	$27,340
2017	2015	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	3	11/8/2016	NON-COMPETING CONTINUATION	-$27,340
														Subtotal = $431,835

Issue Date FY: 2016 ( Subtotal = $431,835 )
2016	2016	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	4	5/13/2016	EXTENSION WITH OR WITHOUT FUNDS	$431,835
														Subtotal = $431,835

Issue Date FY: 2015 ( Subtotal = $427,517 )
2015	2015	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	3	6/11/2015	NON-COMPETING CONTINUATION	$427,517
														Subtotal = $427,517

Issue Date FY: 2014 ( Subtotal = $436,085 )
2014	2014	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	2	6/6/2014	NON-COMPETING CONTINUATION	$436,085
														Subtotal = $436,085

Issue Date FY: 2013 ( Subtotal = $440,165 )
2013	2013	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Related to Deafness and Communication Disorders	000	1	7/8/2013	NEW	$440,165
														Subtotal = $440,165

Grand Total All Awards = $5,450,928

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Targeting of sensory axons in the olfactory bulb

Award Number: R01DC012854

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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