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Perceptual implications of cochlear implant electrode-neuron interfaces

Award Number: R01DC012142
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2012
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Perceptual implications of cochlear implant electrode-neuron interfaces - Project Summary/Abstract Cochlear implants are highly successful neural prostheses that enhance or restore audition to severely hearing-impaired adults and children. Sound from the environment is converted into electrical pulses and conveyed to the auditory nerve by an array of electrodes. The cochlear implant provides important spectral and temporal information to the listener. However, speech perception performance varies considerably among cochlear implant listeners, particularly in noisy environments and for complex stimuli. This variability exists even for children who receive their cochlear implants early in development (<2 years old). Recent evidence suggests that children have a higher density of healthy auditory neurons, which are the target of stimulation through an implant. There is also a critical period for auditory developmental plasticity. The interaction of these factors and the chronic electrical stimulation of a cochlear implant are not well understood, especially for early-implanted children. Despite these known differences between adults and the immature auditory systems of children, cochlear implant research has focused on adults. In adults, the most promising methods for optimizing programming strategies include focusing the electrical field emitted by each electrode to stimulate a more restricted population of neurons and deactivating less effective electrodes. Very few attempts have been made to optimize programming strategies specifically for children, and recent evidence suggests children would benefit more than adults from focused stimulation. Moreover, when new programming strategies are implemented, there is limited data about the timecourse needed to assess their effectiveness. Three aims are proposed: 1) Determine the underlying mechanisms for spectral resolution in children and adults with cochlear implants by comparing peripheral physiological and behavioral tuning across the lifespan; 2) Quantify short-term changes (over hours) in speech perception in children and adults when using optimized programming strategies with selective channel deactivation with and without focused stimulation; and 3) Quantify long-term changes (over weeks) in speech perception in children and adults using the same optimized strategies as in Aim 2. The results of the proposed studies are expected to advance our understanding of how the implanted auditory system develops, how cochlear implants should be programmed to best deliver spectrally challenging signals, and the timecourse of acclimatization to changes in programming strategies. These findings could guide clinical decision making about when to make programming adjustments, what types of adjustments to make, and how long patients need to reach peak performance following adjustments. The results from these studies could ultimately lead to improved functional outcomes for children and adults with cochlear implants.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $582,301 )
2025	2025	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	15	5/23/2025	NON-COMPETING CONTINUATION	$582,301
														Subtotal = $582,301

Issue Date FY: 2024 ( Subtotal = $578,121 )
2024	2024	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	14	6/4/2024	NON-COMPETING CONTINUATION	$578,121
														Subtotal = $578,121

Issue Date FY: 2023 ( Subtotal = $601,151 )
2023	2023	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	13	7/26/2023	NON-COMPETING CONTINUATION	$601,151
2023	2021	MASSACHUSETTS EYE AND EAR INFIRMARY	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	11	6/5/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $601,151

Issue Date FY: 2022 ( Subtotal = $562,403 )
2022	2022	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	12	9/16/2022	COMPETING CONTINUATION	$562,403
2022	2021	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	11	9/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $562,403

Issue Date FY: 2021 ( Subtotal = $361,250 )
2021	2021	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	11	3/17/2021	NON-COMPETING CONTINUATION	$361,250
														Subtotal = $361,250

Issue Date FY: 2020 ( Subtotal = $361,250 )
2020	2020	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	10	3/18/2020	NON-COMPETING CONTINUATION	$361,250
														Subtotal = $361,250

Issue Date FY: 2019 ( Subtotal = $374,844 )
2019	2019	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	9	6/6/2019	NON-COMPETING CONTINUATION	$361,250
2019	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Research Related to Deafness and Communication Disorders	003	7	7/16/2019	NON-COMPETING CONTINUATION	-$47,700
2019	2018	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	8	5/16/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$159,377
2019	2018	MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC.	243 CHARLES ST	BOSTON	MA	02114	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	004	8	7/16/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$47,700
2019	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Research Related to Deafness and Communication Disorders	000	7	5/16/2019	NON-COMPETING CONTINUATION	-$145,783
														Subtotal = $374,844

Issue Date FY: 2018 ( Subtotal = $321,095 )
2018	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Research Related to Deafness and Communication Disorders	000	7	4/12/2018	NON-COMPETING CONTINUATION	$321,095
														Subtotal = $321,095

Issue Date FY: 2017 ( Subtotal = $320,642 )
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Research Related to Deafness and Communication Disorders	001	6	3/27/2017	COMPETING CONTINUATION	$320,642
2017	2017	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Research Related to Deafness and Communication Disorders	003	6	7/25/2017	COMPETING CONTINUATION	$101,595
2017	2016	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Research Related to Deafness and Communication Disorders	002	5	7/25/2017	EXTENSION WITH OR WITHOUT FUNDS	-$101,595
2017	2016	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Research Related to Deafness and Communication Disorders	000	5	3/27/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $320,642

Issue Date FY: 2016 ( Subtotal = $372,124 )
2016	2016	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Research Related to Deafness and Communication Disorders	000	5	1/13/2016	EXTENSION WITH OR WITHOUT FUNDS	$372,124
														Subtotal = $372,124

Issue Date FY: 2015 ( Subtotal = $371,268 )
2015	2015	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Research Related to Deafness and Communication Disorders	000	4	1/15/2015	NON-COMPETING CONTINUATION	$371,268
														Subtotal = $371,268

Issue Date FY: 2014 ( Subtotal = $386,250 )
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Research Related to Deafness and Communication Disorders	000	3	1/23/2014	NON-COMPETING CONTINUATION	$347,625
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Research Related to Deafness and Communication Disorders	001	3	2/10/2014	NON-COMPETING CONTINUATION	$38,625
														Subtotal = $386,250

Issue Date FY: 2013 ( Subtotal = $366,938 )
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Research Related to Deafness and Communication Disorders	001	2	5/16/2013	NON-COMPETING CONTINUATION	$19,313
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Research Related to Deafness and Communication Disorders	000	2	1/24/2013	NON-COMPETING CONTINUATION	$347,625
														Subtotal = $366,938

Issue Date FY: 2012 ( Subtotal = $384,644 )
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Research Related to Deafness and Communication Disorders	000	1	1/27/2012	NEW	$384,644
														Subtotal = $384,644

Grand Total All Awards = $5,944,281

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Perceptual implications of cochlear implant electrode-neuron interfaces

Award Number: R01DC012142

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2012

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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