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Identity and Neural Encoding of Social Odors

Award Number: R01DC010381
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2009
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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View Award Description

Identity and Neural Encoding of Social Odors - ABSTRACT Mammals use pheromones to find mates, regulate reproduction, and organize social behavior. The identification of new pheromones, purified from natural sources, has repeatedly triggered new discoveries about the genes, cells, and circuits essential for social behavior. Recently, my lab identified two novel pheromones present in male mouse urine. These pheromones play an essential role in at least one behavior, the acceleration of puberty in juvenile females. However, several features of these new pheromones, and the responses of the neurons that detect them, suggest an even wider role. Structural clues present in these new compounds hint at a previously-unsuspected mechanism for their detection involving multiple sensory systems, receptor genes, circuit mechanisms, and metabolic pathways. We propose to (1) determine whether a multisensory complex involving both volatile and nonvolatile cues coordinate the discovery, detection, and recognition of these vital cues, (2) identify the receptor genes involved in their detection and consequent behaviors, and (3) test whether stereotyped circuit features contribute to the production and plasticity of suitable behavioral responses. We believe that the new opportunities afforded by these novel pheromones will provide new tools to probe fundamental mechanisms regulating mammalian physiology and behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $407,016 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research Related to Deafness and Communication Disorders	000	14	6/27/2025	NON-COMPETING CONTINUATION	$407,016
														Subtotal = $407,016

Issue Date FY: 2024 ( Subtotal = $465,086 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	13	6/21/2024	NON-COMPETING CONTINUATION	$465,086
														Subtotal = $465,086

Issue Date FY: 2023 ( Subtotal = $419,382 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research Related to Deafness and Communication Disorders	002	12	6/22/2023	NON-COMPETING CONTINUATION	$419,382
2023	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	001	11	12/2/2022	COMPETING CONTINUATION	$2
2023	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	10	12/2/2022	NON-COMPETING CONTINUATION	-$2
														Subtotal = $419,382

Issue Date FY: 2022 ( Subtotal = $433,390 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research Related to Deafness and Communication Disorders	000	11	6/3/2022	COMPETING CONTINUATION	$433,390
														Subtotal = $433,390

Issue Date FY: 2020 ( Subtotal = $324,063 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research Related to Deafness and Communication Disorders	000	10	7/1/2020	NON-COMPETING CONTINUATION	$324,063
														Subtotal = $324,063

Issue Date FY: 2019 ( Subtotal = $324,063 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research Related to Deafness and Communication Disorders	000	9	6/12/2019	NON-COMPETING CONTINUATION	$324,063
														Subtotal = $324,063

Issue Date FY: 2018 ( Subtotal = $324,063 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research Related to Deafness and Communication Disorders	000	8	6/8/2018	NON-COMPETING CONTINUATION	$324,063
														Subtotal = $324,063

Issue Date FY: 2017 ( Subtotal = $324,063 )
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Research Related to Deafness and Communication Disorders	000	7	6/21/2017	NON-COMPETING CONTINUATION	$324,063
														Subtotal = $324,063

Issue Date FY: 2016 ( Subtotal = $324,063 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	6	6/6/2016	COMPETING CONTINUATION	$324,063
														Subtotal = $324,063

Issue Date FY: 2013 ( Subtotal = $294,061 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	5	7/25/2013	NON-COMPETING CONTINUATION	$294,061
														Subtotal = $294,061

Issue Date FY: 2012 ( Subtotal = $309,537 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	4	7/27/2012	NON-COMPETING CONTINUATION	$309,537
														Subtotal = $309,537

Issue Date FY: 2011 ( Subtotal = $247,629 )
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	3	7/21/2011	NON-COMPETING CONTINUATION	$247,629
														Subtotal = $247,629

Issue Date FY: 2010 ( Subtotal = $255,816 )
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	2	7/29/2010	NON-COMPETING CONTINUATION	$255,816
														Subtotal = $255,816

Issue Date FY: 2009 ( Subtotal = $258,400 )
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	1	9/30/2009	NEW	$258,400
														Subtotal = $258,400

Grand Total All Awards = $4,710,632

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Identity and Neural Encoding of Social Odors

Award Number: R01DC010381

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2009

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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