Thursday, December 26, 2024 12/26/2024

Functional development of hair cells and neurons in the inner ear

Award Number: R01DC008853
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project summary Hair cells of the inner ear are the primary receptors of the auditory system. They transduce mechanical information, associated with sound waves, into electro-mechanical (outer hair cells) and electro-chemical (Inner hair cells) signals, which lead to amplification of the initial signal and activation of afferent neuronal fibers, respectively. While hair cells and neuronal fibers appear before birth in mice, development and maturation of the hair cells, neurons and synapses proceeds until hearing onset, ~postnatal day 12. This process is believed to be dynamic and modulated by hair cell activity. In particular, recent work has shown that lack of hair cell transmission, due to absence of functional synapses or defective mechanosensation, leads to altered neuronal maturation and specification. Successful outcomes for new therapies, including gene therapy, aimed at restoring hair cell function after birth, may depend on restoration of auditory circuits, including mature and functional hair cell synapses and neuronal fibers. Here we propose to assess how disruption or loss of sensory transduction in several mouse models affects hair cell function, synaptic maturation and spiral ganglion specification. Furthermore, we will determine if inner ear gene therapy is capable of reversing any of these observed changes and identify the conditions for optimal recovery of auditory function. We will combine state-of-the-art technologies to address these important questions, including high-resolution imaging, electrophysiology, single cell RNA sequencing and localization of RNA transcripts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $475,716 )
2025	2025	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	15	11/18/2024	NON-COMPETING CONTINUATION	$475,716
														Subtotal = $475,716

Issue Date FY: 2024 ( Subtotal = $538,657 )
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	14	11/15/2023	NON-COMPETING CONTINUATION	$484,792
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	14	5/2/2024	NON-COMPETING CONTINUATION	$53,865
														Subtotal = $538,657

Issue Date FY: 2023 ( Subtotal = $571,758 )
2023	2023	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	13	1/13/2023	NON-COMPETING CONTINUATION	$57,175
2023	2023	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	13	11/18/2022	NON-COMPETING CONTINUATION	$514,583
														Subtotal = $571,758

Issue Date FY: 2022 ( Subtotal = $543,464 )
2022	2022	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	12	4/22/2022	NON-COMPETING CONTINUATION	$54,346
2022	2022	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	12	11/17/2021	NON-COMPETING CONTINUATION	$489,118
														Subtotal = $543,464

Issue Date FY: 2021 ( Subtotal = $575,994 )
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	11	10/26/2020	COMPETING CONTINUATION	$575,994
														Subtotal = $575,994

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	10	12/19/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $369,750 )
2017	2017	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	10	7/20/2017	NON-COMPETING CONTINUATION	$369,750
2017	2016	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	9	1/24/2017	EXTENSION WITH OR WITHOUT FUNDS	$72,151
2017	2015	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	8	1/24/2017	NON-COMPETING CONTINUATION	-$72,151
														Subtotal = $369,750

Issue Date FY: 2016 ( Subtotal = $369,750 )
2016	2016	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	9	7/20/2016	EXTENSION WITH OR WITHOUT FUNDS	$369,750
														Subtotal = $369,750

Issue Date FY: 2015 ( Subtotal = $366,052 )
2015	2015	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	8	7/16/2015	NON-COMPETING CONTINUATION	$366,052
														Subtotal = $366,052

Issue Date FY: 2014 ( Subtotal = $369,750 )
2014	2014	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	7	7/22/2014	NON-COMPETING CONTINUATION	$369,750
														Subtotal = $369,750

Issue Date FY: 2013 ( Subtotal = $369,750 )
2013	2013	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	6	8/6/2013	COMPETING CONTINUATION	$369,750
														Subtotal = $369,750

Issue Date FY: 2011 ( Subtotal = $348,728 )
2011	2011	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	6/22/2011	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$304,509
2011	2011	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	5	6/23/2011	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$44,219
														Subtotal = $348,728

Issue Date FY: 2010 ( Subtotal = $314,576 )
2010	2010	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Research Related to Deafness and Communication Disorders	000	4	6/15/2010	NON-COMPETING CONTINUATION	$314,576
														Subtotal = $314,576

Issue Date FY: 2009 ( Subtotal = $476,630 )
2009	2009	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Research Related to Deafness and Communication Disorders	001	3	6/16/2009	NON-COMPETING CONTINUATION	$317,753
2009	2009	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Trans-NIH Recovery Act Research Support	000	2	7/15/2009	SUPPLEMENT FOR EXPANSION	$158,877
														Subtotal = $476,630

Issue Date FY: 2008 ( Subtotal = $317,753 )
2008	2008	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Research Related to Deafness and Communication Disorders	000	2	6/18/2008	NON-COMPETING CONTINUATION	$317,753
														Subtotal = $317,753

Issue Date FY: 2007 ( Subtotal = $321,938 )
2007	2007	UNIVERSITY OF VIRGINIA	PO BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Research Related to Deafness and Communication Disorders	000	1	6/15/2007	NEW	$321,938
														Subtotal = $321,938

Grand Total All Awards = $6,330,266

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Functional development of hair cells and neurons in the inner ear

Award Number: R01DC008853

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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