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Regulation of taste neuron morphology and function

Award Number: R01DC007176
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Regulation of taste neuron morphology and function - Project Summary: Taste-transducing cells detect chemicals in our food and communicate this information to peripheral taste ganglion neurons (taste neurons), which carry this information to the brain. The axons of taste neurons vary in branching characteristics, some branching little and others branching a great deal. However, it is unclear how these differing morphologies underly plasticity and/or function. Our goal here is to clarify the relationship between taste neuron morphology, plasticity, genetic type, and function in order to gain insight into the peripheral organization of the taste system. Taste neuron morphology may underlie differences in connectivity, but is also likely regulated by plasticity. Even in adults, taste receptor cells undergo continuous renewal and must constantly attract and connect to nerve fibers, and some variation in neuron morphology likely occurs as part of this process. Additionally, differences between neurons in their branching likely have functional importance. For example, simply branched neurons can only connect with a few taste-transducing cells, while heavily branched neurons likely connect to many more taste-transducing cells. Currently, the significance of these differences in convergence are unclear. In this project, we propose to investigate factors that regulate differences in taste neuron morphology and branching characteristics between neurons and relate these factors to neuron function. Specifically, in Aim 1, we will determine which aspects of the axon morphologies of taste neurons are stable and which change over time. In Aim 2, we will determine which aspects of neuron morphologies are determined by an intrinsic factor (i.e., cell type) and how this factor correlates with function. Finally, in Aim 3, we will determine which aspects of neuron morphologies are determined by extrinsic (i.e., neurotrophins) developmental factors and how these features relate to neuron function. We hypothesize that branching inside the taste bud is regulated by plasticity, while branching outside the taste bud is regulated by a combination of intrinsic and extrinsic features, which influence taste neuron sensitivity and breadth of tuning.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $372,933 )
2025	2025	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	20	2/14/2025	NON-COMPETING CONTINUATION	$372,933
														Subtotal = $372,933

Issue Date FY: 2024 ( Subtotal = $504,131 )
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	002	19	2/22/2024	SUPPLEMENT FOR EXPANSION	$60,157
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	18	12/28/2023	SUPPLEMENT FOR EXPANSION	$29,604
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	19	2/22/2024	NON-COMPETING CONTINUATION	$372,933
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	003	19	5/7/2024	NON-COMPETING CONTINUATION	$41,437
														Subtotal = $504,131

Issue Date FY: 2023 ( Subtotal = $414,370 )
2023	2023	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	18	3/13/2023	NON-COMPETING CONTINUATION	$414,370
2023	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	002	17	6/9/2023	COMPETING CONTINUATION	$152,340
2023	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	16	6/9/2023	NON-COMPETING CONTINUATION	-$152,340
														Subtotal = $414,370

Issue Date FY: 2022 ( Subtotal = $449,691 )
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	17	2/22/2022	COMPETING CONTINUATION	$449,691
2022	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	16	2/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $449,691

Issue Date FY: 2020 ( Subtotal = $409,502 )
2020	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	16	5/29/2020	NON-COMPETING CONTINUATION	$395,799
2020	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	15	11/7/2019	SUPPLEMENT FOR EXPANSION	$13,703
														Subtotal = $409,502

Issue Date FY: 2019 ( Subtotal = $395,799 )
2019	2019	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	15	6/13/2019	NON-COMPETING CONTINUATION	$395,799
														Subtotal = $395,799

Issue Date FY: 2018 ( Subtotal = $395,799 )
2018	2018	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	14	6/21/2018	NON-COMPETING CONTINUATION	$395,799
														Subtotal = $395,799

Issue Date FY: 2017 ( Subtotal = $395,799 )
2017	2017	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	002	13	6/13/2017	NON-COMPETING CONTINUATION	$395,799
2017	2016	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	12	1/13/2017	COMPETING CONTINUATION	$228,389
2017	2015	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	11	1/13/2017	NON-COMPETING CONTINUATION	-$228,389
														Subtotal = $395,799

Issue Date FY: 2016 ( Subtotal = $442,258 )
2016	2016	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	12	7/8/2016	COMPETING CONTINUATION	$442,258
2016	2015	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	11	7/6/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $442,258

Issue Date FY: 2015 ( Subtotal = $424,418 )
2015	2015	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	11	5/12/2015	NON-COMPETING CONTINUATION	$424,418
														Subtotal = $424,418

Issue Date FY: 2014 ( Subtotal = $425,408 )
2014	2014	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	10	5/9/2014	SUPPLEMENT FOR EXPANSION	$41,511
2014	2014	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	10	5/7/2014	NON-COMPETING CONTINUATION	$383,897
														Subtotal = $425,408

Issue Date FY: 2013 ( Subtotal = $364,702 )
2013	2013	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	9	5/16/2013	NON-COMPETING CONTINUATION	$364,702
														Subtotal = $364,702

Issue Date FY: 2012 ( Subtotal = $383,897 )
2012	2012	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	8	5/8/2012	NON-COMPETING CONTINUATION	$383,897
														Subtotal = $383,897

Issue Date FY: 2011 ( Subtotal = $426,080 )
2011	2011	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	7	4/25/2011	COMPETING CONTINUATION	$426,080
2011	2011	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	002	7	6/6/2011	COMPETING CONTINUATION	$0
2011	2010	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	6	4/21/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $426,080

Issue Date FY: 2010 ( Subtotal = $102,147 )
2010	2010	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	6	2/3/2010	NON-COMPETING CONTINUATION	$102,147
2010	2009	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Trans-NIH Recovery Act Research Support	001	5	5/14/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $102,147

Issue Date FY: 2009 ( Subtotal = $431,114 )
2009	2009	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	001	5	3/18/2009	NON-COMPETING CONTINUATION	$30,919
2009	2009	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	5	2/11/2009	NON-COMPETING CONTINUATION	$278,261
2009	2009	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Trans-NIH Recovery Act Research Support	002	5	7/15/2009	SUPPLEMENT FOR EXPANSION	$121,934
														Subtotal = $431,114

Issue Date FY: 2008 ( Subtotal = $309,180 )
2008	2008	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Research Related to Deafness and Communication Disorders	000	4	2/14/2008	NON-COMPETING CONTINUATION	$309,180
														Subtotal = $309,180

Grand Total All Awards = $7,638,457

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Regulation of taste neuron morphology and function

Award Number: R01DC007176

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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