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Neural Mechanisms of Vestibular Function

Award Number: R01DC004260
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Neural Mechanisms of Vestibular Function - PROJECT SUMMARY We investigate an important function of the vestibular system, and its multisensory properties, in spatial navigation, specifically head direction (HD) cells. HD cells encode directional heading like a compass and these properties are generated through a ring attractor network that is defined by orienting landmarks and updated using self-motion velocity cues. The goal of this renewal application is to establish the principles and circuits linking vestibular signals to HD cells in the anterior thalamus, through three aims. In the first two aims we will thoroughly test theory-driven hypotheses about the self-motion signal that updates the ring attractor. We will disentangle two contributions to HD tuning strength: self-motion velocity input, and brain state, which we hypothesize exerts a tonic modulatory role on the intrinsic properties of the attractor itself. We will show that passive rotations are as effective in updating the HD attractor as active foraging, and will test model-driven hypotheses about their multisensory properties. In Aim 3 we will genetically and optogenetically manipulate large or discrete regions of the cerebellum while monitoring the activity of HD cells in anterodorsal and laterodorsal thalamus. The hypothesized role of multisensory cerebellar signals is 2-fold: to help maintain internal models about 1) rotation velocity, and 2) gravity. The former updates the firing and the latter defines the 3D tuning of HD cells. Collectively, these experiments will provide a long-overdue, thorough and quantitative understanding of the multisensory properties of one of the most important components of the spatial navigation circuit. Our strength is an interdisciplinary approach based on a quantitative understanding of both multisensory and computational neuroscience, which promises novel insights into the organization of the spatial properties of HD cells and their links with the vestibular system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	26	10/17/2023	NON-COMPETING CONTINUATION	$0
2024	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	26	5/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $589,263 )
2023	2023	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	26	8/11/2023	NON-COMPETING CONTINUATION	$589,263
														Subtotal = $589,263

Issue Date FY: 2022 ( Subtotal = $589,263 )
2022	2022	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	25	8/12/2022	NON-COMPETING CONTINUATION	$589,263
														Subtotal = $589,263

Issue Date FY: 2021 ( Subtotal = $601,388 )
2021	2021	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	002	24	8/20/2021	NON-COMPETING CONTINUATION	$601,388
2021	2020	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	23	6/17/2021	COMPETING CONTINUATION	$209,302
2021	2019	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	22	6/17/2021	NON-COMPETING CONTINUATION	-$209,302
														Subtotal = $601,388

Issue Date FY: 2020 ( Subtotal = $643,030 )
2020	2020	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	23	8/4/2020	COMPETING CONTINUATION	$643,030
														Subtotal = $643,030

Issue Date FY: 2019 ( Subtotal = $628,016 )
2019	2019	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	004	22	8/28/2019	NON-COMPETING CONTINUATION	$620,350
2019	2018	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	21	1/11/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$630,240
2019	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	20	1/9/2019	NON-COMPETING CONTINUATION	-$622,574
2019	2018	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Research Related to Deafness and Communication Disorders	003	21	5/14/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$463,445
2019	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	002	19	5/14/2019	NON-COMPETING CONTINUATION	-$463,445
														Subtotal = $628,016

Issue Date FY: 2018 ( Subtotal = $622,574 )
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	20	8/20/2018	NON-COMPETING CONTINUATION	$622,574
2018	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	19	3/14/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $622,574

Issue Date FY: 2017 ( Subtotal = $647,094 )
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	19	4/21/2017	NON-COMPETING CONTINUATION	$582,387
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	19	5/24/2017	NON-COMPETING CONTINUATION	$64,707
														Subtotal = $647,094

Issue Date FY: 2016 ( Subtotal = $724,081 )
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	18	3/17/2016	NON-COMPETING CONTINUATION	$724,081
														Subtotal = $724,081

Issue Date FY: 2015 ( Subtotal = $704,004 )
2015	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	17	3/4/2015	COMPETING CONTINUATION	$642,266
2015	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	002	17	3/9/2015	SUPPLEMENT FOR EXPANSION	$67,147
2015	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	16	3/4/2015	NON-COMPETING CONTINUATION	-$5,409
														Subtotal = $704,004

Issue Date FY: 2014 ( Subtotal = $540,778 )
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	16	11/5/2013	NON-COMPETING CONTINUATION	$486,696
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	16	2/10/2014	NON-COMPETING CONTINUATION	$54,082
														Subtotal = $540,778

Issue Date FY: 2013 ( Subtotal = $521,499 )
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	000	15	11/1/2012	NON-COMPETING CONTINUATION	$494,052
2013	2013	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	001	15	5/10/2013	NON-COMPETING CONTINUATION	$27,447
														Subtotal = $521,499

Issue Date FY: 2012 ( Subtotal = $519,967 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	001	13	1/25/2012	NON-COMPETING CONTINUATION	$45,390
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	003	13	8/7/2012	NON-COMPETING CONTINUATION	-$538,364
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	13	12/9/2011	NON-COMPETING CONTINUATION	$500,448
2012	2012	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Research Related to Deafness and Communication Disorders	002	14	8/7/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$512,493
														Subtotal = $519,967

Issue Date FY: 2011 ( Subtotal = $561,239 )
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	001	12	5/27/2011	NON-COMPETING CONTINUATION	$39,140
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	12	10/28/2010	NON-COMPETING CONTINUATION	$522,099
														Subtotal = $561,239

Issue Date FY: 2010 ( Subtotal = $581,777 )
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	11	11/17/2009	COMPETING CONTINUATION	$581,777
2010	2008	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	001	10	11/17/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $581,777

Issue Date FY: 2008 ( Subtotal = $313,598 )
2008	2008	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Research Related to Deafness and Communication Disorders	000	10	7/21/2008	NON-COMPETING CONTINUATION	$313,598
														Subtotal = $313,598

Grand Total All Awards = $11,236,498

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Neural Mechanisms of Vestibular Function

Award Number: R01DC004260

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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