Tuesday, April 23, 2024 4/23/2024

Experimental_Theoretical_Studies_of_Cochlear_Mechanisms

Award Number: R01DC000238
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Based on its strategic location, the tectorial membrane (TM) has long been believed to play an essential role in hearing, but the important cochlear mechanisms remain unclear. We propose research to improve our understanding of the functional role of the TM in determining (1) the remarkable properties of normal hearing — including its exquisite sensitivity and frequency selectivity — as well as (2) the hearing loss associated with genetic mutations of the TM and other cochlear pathologies. The proposed research is organized with three related aims. Aim 1: We propose to characterize TM material properties that determine local interactions between the TM, hair bundles, and surrounding ¿uid. We will measure the poroelastic and electrokinetic properties of the TM that interact with the hair bundles at micro- and nano-scales. Aim 2: We propose to measure radial and transverse modes of TM motion that stimulate motions of inner and outer hair cells. Recent studies have challenged the conventional notion that hair bundle motions are generated exclusively by shearing motions of the TM (and subtectorial ¿uid) relative to the reticular lamina. In addition to radial modes of motion (e.g., resonance models), complex linkages between transverse and radial modes of TM motion are thought to be signi¿cant, especially for low-frequency stimulation of inner hair cells. Aim 3: We propose to characterize TM traveling waves and tuning in humans compared to mice, gerbils and guinea pigs. While the cross-sectional structure of the mammal cochlea is highly conserved across species, the sensitivity and frequency selectivity of hearing di¿ers greatly. Recently, the sharp frequency tuning in Tectb-/- mutant mice relative to wild-type mice has been linked to di¿erences in longitudinal coupling via TM traveling waves. We propose to test the generality of the relation between wave properties and tuning across mammalian species, including humans. We will measure TM material properties (e.g., shearing sti¿ness and viscous moduli), morphology (e.g., width, thickness, number and orientation of radial ¿bers), and TM wave properties in mice, gerbils, guinea pigs, and humans. Results from these three aims will increase our understanding of the cochlear mechanisms that underlie both normal and abnormal hearing. This knowledge has important practical applications for the delineation of inner-ear disorders (and concomitant suggestions for treatment) and for the design of speech-processing devices such as cochlear implants, hearing aids, and speech-recognition systems.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $332,220 )
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	38	11/28/2023	NON-COMPETING CONTINUATION	$332,220
														Subtotal = $332,220

Issue Date FY: 2023 ( Subtotal = $369,690 )
2023	2023	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	37	1/11/2023	COMPETING CONTINUATION	$7,912
2023	2023	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	37	10/27/2022	COMPETING CONTINUATION	$361,778
														Subtotal = $369,690

Issue Date FY: 2021 ( Subtotal = $378,820 )
2021	2021	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	36	10/27/2020	NON-COMPETING CONTINUATION	$340,938
2021	2021	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	36	1/7/2021	NON-COMPETING CONTINUATION	$37,882
														Subtotal = $378,820

Issue Date FY: 2020 ( Subtotal = $378,820 )
2020	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	35	11/1/2019	NON-COMPETING CONTINUATION	$340,938
2020	2020	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	35	1/15/2020	NON-COMPETING CONTINUATION	$37,882
														Subtotal = $378,820

Issue Date FY: 2019 ( Subtotal = $378,820 )
2019	2019	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	34	11/8/2018	NON-COMPETING CONTINUATION	$378,820
														Subtotal = $378,820

Issue Date FY: 2018 ( Subtotal = $378,820 )
2018	2018	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	33	4/3/2018	NON-COMPETING CONTINUATION	$37,882
2018	2018	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	33	11/2/2017	NON-COMPETING CONTINUATION	$340,938
														Subtotal = $378,820

Issue Date FY: 2017 ( Subtotal = $385,633 )
2017	2017	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	32	1/31/2017	COMPETING CONTINUATION	$385,633
2017	2016	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	31	3/27/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $385,633

Issue Date FY: 2016 ( Subtotal = $301,247 )
2016	2016	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	31	1/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$30,124
2016	2016	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	31	10/23/2015	EXTENSION WITH OR WITHOUT FUNDS	$271,123
														Subtotal = $301,247

Issue Date FY: 2015 ( Subtotal = $299,251 )
2015	2015	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	30	1/13/2015	NON-COMPETING CONTINUATION	$27,204
2015	2015	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	30	11/3/2014	NON-COMPETING CONTINUATION	$272,047
														Subtotal = $299,251

Issue Date FY: 2014 ( Subtotal = $303,235 )
2014	2014	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	29	2/5/2014	NON-COMPETING CONTINUATION	$30,448
2014	2014	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	29	11/20/2013	NON-COMPETING CONTINUATION	$272,787
														Subtotal = $303,235

Issue Date FY: 2013 ( Subtotal = $288,951 )
2013	2013	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	28	10/25/2012	NON-COMPETING CONTINUATION	$273,744
2013	2013	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	28	5/10/2013	NON-COMPETING CONTINUATION	$15,207
														Subtotal = $288,951

Issue Date FY: 2012 ( Subtotal = $305,147 )
2012	2012	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	002	27	1/12/2012	COMPETING CONTINUATION	$0
2012	2012	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	27	1/6/2012	COMPETING CONTINUATION	-$10,720
2012	2012	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	27	12/7/2011	COMPETING CONTINUATION	$315,867
														Subtotal = $305,147

Issue Date FY: 2011 ( Subtotal = $235,021 )
2011	2011	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	26	11/1/2010	NON-COMPETING CONTINUATION	$218,511
2011	2011	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	26	5/27/2011	NON-COMPETING CONTINUATION	$16,510
														Subtotal = $235,021

Issue Date FY: 2010 ( Subtotal = $243,439 )
2010	2010	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	25	1/21/2010	NON-COMPETING CONTINUATION	$22,131
2010	2010	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	25	11/6/2009	NON-COMPETING CONTINUATION	$221,308
														Subtotal = $243,439

Issue Date FY: 2009 ( Subtotal = $246,531 )
2009	2009	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	001	24	3/16/2009	NON-COMPETING CONTINUATION	$24,653
2009	2009	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	24	11/14/2008	NON-COMPETING CONTINUATION	$221,878
														Subtotal = $246,531

Issue Date FY: 2008 ( Subtotal = $247,143 )
2008	2008	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	23	11/20/2007	NON-COMPETING CONTINUATION	$247,143
														Subtotal = $247,143

Issue Date FY: 2007 ( Subtotal = $250,997 )
2007	2007	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	22	12/7/2006	COMPETING CONTINUATION	$250,997
														Subtotal = $250,997

Issue Date FY: 2004 ( Subtotal = $422,444 )
2004	2004	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	21	5/28/2004	NON-COMPETING CONTINUATION	$422,444
														Subtotal = $422,444

Grand Total All Awards = $8,147,557

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Experimental_Theoretical_Studies_of_Cochlear_Mechanisms

Award Number: R01DC000238

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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