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Assessing the Abuse Liability of 6-Methyl Nicotine

Award Number: R01DA065318
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Assessing the Abuse Liability of 6-Methyl Nicotine - Summary Electronic nicotine delivery systems (i.e., ENDS) use in the U.S. and around the world remains the most prevalent form of nicotine use among adolescents and young adults and poses a significant public health concern. An emerging issue in this area is the use of synthetic nicotine analogs in ENDS by manufacturers in order to bypass regulatory considerations focusing on nicotine alone. This proposal will test the hypothesis that one such analog, 6-methyl nicotine, is biologically, pharmacologically and behaviorally similar to nicotine, with potentially increased risk of dependence and toxicity in animal models. In Aim 1, we will determine the Determine the rewarding and aversive properties of 6-methyl nicotine and compare it to nicotine. In Aim 2, we will compare the abuse liability of 6-methyl nicotine and nicotine in translationally validated rodent behavioral models. In Aim 3 we will compare the pharmacokinetic profile and associated parameters of 6- methyl nicotine and nicotine in mice. The findings from this proposal will have direct and immediate translational value to inform public health, public policy and regulatory decisions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $657,471 )
2026	2026	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	1	8/19/2026	NEW	$657,471
														Subtotal = $657,471

Grand Total All Awards = $657,471

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Assessing the Abuse Liability of 6-Methyl Nicotine

Award Number: R01DA065318

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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