Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Mechanistic studies of opiate withdrawal-induced sleep disturbances

Award Number: R01DA061306
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2029

Group Awards By:

View Award Description

Mechanistic studies of opiate withdrawal-induced sleep disturbances - PROJECT SUMMARY The majority of patients with Opioid Use Disorder (OUD) report sleep problems such as insomnia. Sleep disruption commonly occurs during opiate withdrawal and has been considered as a major factor that contributes to relapse. However, little is known about the underlying mechanisms, and the circuits/neurons/genes that are involved. One of major component of both the opioid withdrawal and arousal circuitry resides in the monoaminergic nuclei—the locus coeruleus (LC), which is known to abundantly express µ-opioid receptors, mediates opioid withdrawal symptoms, and promote wakefulness. In the proposed project, we will combine activity-dependent labelling and intersectional strategies to specifically target the wake-active populations of LC noradrenergic (LCNE-Wake) neurons and determine whether they are critical for morphine withdrawal-induced sleep disturbances. In Aim 1, using cutting-edge systems neuroscience tools, we will determine whether spontaneous withdrawal from chronic morphine administration disrupts the neuronal activity and membrane properties of LCNE-Wake neurons, and functionally and molecularly characterize these dysfunctional neurons. In Aim 2, we will further evaluate the functional role of major presynaptic inputs of LC, gigantocellular reticular nucleus (Gi) of medulla in withdrawal-induced sleep disturbances, test whether activation of GABAergic neurons in Gi can sufficiently mitigate the dysregulated sleep, and lastly map the spatial transcriptomic signatures of Gi-LC neurobiological pathway during morphine withdrawal. Successful completion of these aims will advance our understanding of the circuit mechanisms underlying OUD-associated sleep disturbances, potentially leading to the development of effective therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $414,450 )
2026	2026	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Drug Use and Addiction Research Programs	000	3	4/29/2026	NON-COMPETING CONTINUATION	$414,450
														Subtotal = $414,450

Issue Date FY: 2025 ( Subtotal = $414,450 )
2025	2025	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Drug Use and Addiction Research Programs	000	2	4/21/2025	NON-COMPETING CONTINUATION	$414,450
														Subtotal = $414,450

Issue Date FY: 2024 ( Subtotal = $414,450 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Drug Use and Addiction Research Programs	000	1	7/10/2024	NEW	$414,450
														Subtotal = $414,450

Grand Total All Awards = $1,243,350

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mechanistic studies of opiate withdrawal-induced sleep disturbances

Award Number: R01DA061306

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer