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Pharmacology of Stimulant Choice

Award Number: R01DA055825
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Pharmacology of Stimulant Choice - This new R01 application proposes a systematic series of experiments focused on drug-choice procedures in male and female rats to evaluate the muscarinic acetylcholine receptor (mAChR)1 agonist VU0364572 as a candidate medication for treatment of cocaine and methamphetamine use disorder. This application is founded on the premise that stimulant use disorder in humans can be studied using preclinical assays of drug-vs-food choice that model clinical aspects of behavioral misallocation and decision making between concurrently available drugs and an alternative nondrug reinforcer. We propose to determine 1) VU0364572 effects on cocaine-food and cocaine-social choice, 2) VU0364572 effects on methamphetamine-food and methamphetamine-social choice, and 3) VU0364572 effects on nucleus accumbens and prefrontal cortex dopamine release using dLight.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $349,313 )
2025	2025	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	3	2/27/2025	NON-COMPETING CONTINUATION	$314,381
2025	2025	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	3	4/10/2025	NON-COMPETING CONTINUATION	$34,932
														Subtotal = $349,313

Issue Date FY: 2024 ( Subtotal = $349,313 )
2024	2024	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	2	4/25/2024	NON-COMPETING CONTINUATION	$34,932
2024	2024	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	2	2/23/2024	NON-COMPETING CONTINUATION	$314,381
														Subtotal = $349,313

Issue Date FY: 2023 ( Subtotal = $349,313 )
2023	2023	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	1	4/5/2023	NEW	$349,313
														Subtotal = $349,313

Grand Total All Awards = $1,047,939

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Pharmacology of Stimulant Choice

Award Number: R01DA055825

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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