Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Regulation of Gene Expression in the Human Habenula in Comorbid Opioid Addiction and Depression

Award Number: R01DA055823
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2027

Group Awards By:

View Award Description

Regulation of Gene Expression in the Human Habenula in Comorbid Opioid Addiction and Depression - PROJECT SUMMARY/ABSTRACT Drug addiction is highly comorbid with neuropsychiatric disorders, especially major depressive disorder (MDD). Both conditions are moderately heritable and exacerbated by environmental factors, particularly stressful life events, suggesting combined genetic and epigenetic liability. Furthermore, both illnesses feature dysregulation of dopaminergic (DA) and serotonergic (5HT) systems modulating motivation and cognitive function. The habenula (Hb) is one of the few brain regions controlling both DA and 5HT systems and is a highly organized central node for reward circuits governing motivated behavior and affective states. Hb dysfunction is associated with impaired mood regulation and substance use disorder (SUD), but the genetic and epigenetic mechanisms mediating this dysfunction are unknown. Given the close relationship between brain structure and function, assigning gene expression to functionally distinct anatomical subdivisions and cell populations within the human Hb would significantly advance our understanding of how Hb dysregulation contributes to neuropsychiatric disorders and SUD. Towards this end, we propose to employ 10x Genomics Multi-ome and Visium technologies to generate corresponding single cell and spatial molecular reference maps of human Hb to identify genetically-defined and topographically-organized cell types across medial and lateral subdivisions of this brain region. We will also generate transcriptomic data from homogenate human Hb in patients with MDD and comorbid MDD/opioid use disorder (OUD), and contrast these gene expression patterns to those derived from matched neurotypical controls. We will integrate complimentary topographic and cell type- specific reference maps with homogenate data from patients with depression and addiction to implicate specific Hb cell populations and subregions in illness state and genetic risk for these highly comorbid conditions. By generating the first molecular neuroanatomical atlas of the human habenula, we will facilitate refined annotation of cell types with brain architecture in a key integration hub of brain reward circuitry that can be targeted for prevention and treatment of debilitating neuropsychiatric and substance use disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $680,018 )
2025	2025	THE LIEBER INSTITUTE	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	4	4/16/2025	NON-COMPETING CONTINUATION	$680,018
														Subtotal = $680,018

Issue Date FY: 2024 ( Subtotal = $671,089 )
2024	2024	THE LIEBER INSTITUTE	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	3	6/5/2024	NON-COMPETING CONTINUATION	$671,089
														Subtotal = $671,089

Issue Date FY: 2023 ( Subtotal = $646,796 )
2023	2023	LIEBER INSTITUTE, INC.	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	2	4/17/2023	NON-COMPETING CONTINUATION	$646,796
														Subtotal = $646,796

Issue Date FY: 2022 ( Subtotal = $667,421 )
2022	2022	LIEBER INSTITUTE, INC.	855 N WOLFE ST STE 300	BALTIMORE	MD	21205	BALTIMORE CITY	USA	Drug Use and Addiction Research Programs	000	1	6/22/2022	NEW	$667,421
														Subtotal = $667,421

Grand Total All Awards = $2,665,324

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Regulation of Gene Expression in the Human Habenula in Comorbid Opioid Addiction and Depression

Award Number: R01DA055823

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer