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Street Experiences, Affect, and Coping: Harnessing Computational Models for the Development of a Cellphone-Based Intervention to Prevent Drug Use among Youth Experiencing Homelessness

Award Number: R01DA054969
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Street Experiences, Affect, and Coping: Harnessing Computational Models for the Development of a Cellphone-Based Intervention to Prevent Drug Use among Youth Experiencing Homelessness - ABSTRACT Youth experiencing homelessness (YEH) face many significant risks that are detrimental to their long-term well- being and survival, including engaging in negative coping behaviors such as alcohol and drug use. 89% of YEH report lifetime alcohol use, 77% marijuana use, and 48% report methamphetamine use. Drug and alcohol use prevalence rates are 2 to 3 times higher among YEH than in their housed peers, leading to poorer mental health and HIV outcomes for this population. Proximal risk factors for substance use in YEH include street victimization: 39% and 94% have been sexually or physically victimized, respectively; poor mental health: 80% and 74% meet diagnostic criteria for PTSD and depression, respectively; and risky social networks: 62% of YEH report drug use with a network member. Another risk factor for substance is affect regulation. Studies of general population youth find that those with greater negative affect have higher rates of substance use. The role of affect regulation has rarely been examined for YEH; thus, mediating mechanisms are unclear. It is possible that proximal risk factors increase negative affect, leading to greater substance use among YEH. Understanding these linkages is key to developing predictive models of coping. This project uses a socio-ecological framework to examine linkages between Proximal risk factors, Affect regulation, and Coping behaviors. Specifically, we will identify factors that influence positive vs. negative coping behavior for YEH to develop a data-driven intervention that: 1) is relevant to this vulnerable population, and provides individualized support, and 2) can be sustainable outside the research setting. Our team has pioneered the use of cellphones for ecological momentary assessment (EMA) in public health research (Khan), and with YEH (Tyler and Olson). Increased cellphone ownership among YEH alongside growth in urban WiFi hotspot coverage together create a public health opportunity leveraged in this project's aims: 1) determine whether affect regulation mediates the relationship between YEHs’ proximal risk factors and coping behaviors, achieved by analyzing survey data and EMA data on Proximal risk factors, Affect regulation, and Coping behaviors collected via app-based responsive EMA (rEMA) in an observational cohort study of N=300 YEH over 60 days; 2) develop a data-driven app-based just-in-time personal support intervention (JIT-PSI) that delivers responsive messaging to mitigate negative coping in favor of positive coping. This aim is achieved by developing predictive models of coping behavior based on machine learning analyses of Aim 1’s survey and rEMA data; and conducting focus groups with N=30 YEH and meetings with N=15 agency staff to design intervention messaging content responsive to a range of coping behaviors; 3) test the feasibility and acceptability of the JIT-PSI, achieved by an observational cohort study of N=300 YEH over 60 days, using surveys, alongside cellphone based rEMA, and JIT intervention delivery. Leveraging growing number of public free WiFi hotspots and shrinking cellphone hardware costs, this project will yield significant public health impacts by developing a sustainable, JIT behavioral intervention for the prevention of drug use among YEH.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $712,518 )
2025	2025	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Drug Use and Addiction Research Programs	000	4	6/18/2025	NON-COMPETING CONTINUATION	$712,518
														Subtotal = $712,518

Issue Date FY: 2024 ( Subtotal = $713,399 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST	LINCOLN	NE	68503	LANCASTER	USA	Drug Use and Addiction Research Programs	000	3	5/17/2024	NON-COMPETING CONTINUATION	$713,399
														Subtotal = $713,399

Issue Date FY: 2023 ( Subtotal = $675,410 )
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Drug Use and Addiction Research Programs	000	2	6/21/2023	NON-COMPETING CONTINUATION	$675,410
														Subtotal = $675,410

Issue Date FY: 2022 ( Subtotal = $641,411 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Drug Use and Addiction Research Programs	000	1	8/15/2022	NEW	$641,411
														Subtotal = $641,411

Grand Total All Awards = $2,742,738

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Street Experiences, Affect, and Coping: Harnessing Computational Models for the Development of a Cellphone-Based Intervention to Prevent Drug Use among Youth Experiencing Homelessness

Award Number: R01DA054969

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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