Tuesday, January 13, 2026 1/13/2026

Extensions of Mendelian Randomization Methodology for Combined Genomic and Methylomic Analysis

Award Number: R01DA049867
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Extensions of Mendelian Randomization Methodology for Combined Genomic and Methylomic Analysis - Project Summary This project aims to develop and apply novel statistical approaches to address key causal questions in the of substance use, abuse and dependence. The development will focus on extending Mendelian Randomization methodology to new data types that test its key assumptions. These developments include: estimating and controlling for biases due to non- random mating; analyses of data from unrelated but genotyped individuals; extension to longitudinal data; multivariate network models; and multiple-group analyses to test for sex, age and other group differences. These new methods will be applied to unique longitudinal phenotype, genotype and methylation data on smokers and non- smokers from the Netherlands Twin Register, and data from the UK biobank. Precise identification of causal pathways will enable evidence- based prevention and treatment methods to be devised and implemented.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	5	12/3/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $315,229 )
2024	2024	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	5	5/27/2024	NON-COMPETING CONTINUATION	$315,229
														Subtotal = $315,229

Issue Date FY: 2023 ( Subtotal = $323,183 )
2023	2023	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	4	5/18/2023	NON-COMPETING CONTINUATION	$323,183
														Subtotal = $323,183

Issue Date FY: 2022 ( Subtotal = $556,052 )
2022	2022	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	3	8/12/2022	SUPPLEMENT FOR EXPANSION	$232,869
2022	2022	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	3	5/5/2022	NON-COMPETING CONTINUATION	$323,183
														Subtotal = $556,052

Issue Date FY: 2021 ( Subtotal = $355,900 )
2021	2021	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	2	5/11/2021	NON-COMPETING CONTINUATION	$355,900
														Subtotal = $355,900

Issue Date FY: 2020 ( Subtotal = $374,370 )
2020	2020	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	1	6/23/2020	NEW	$374,370
														Subtotal = $374,370

Grand Total All Awards = $1,924,734

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Extensions of Mendelian Randomization Methodology for Combined Genomic and Methylomic Analysis

Award Number: R01DA049867

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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