Tuesday, October 15, 2024 10/15/2024

Lateral Hypothalamic Circuits for Feeding and Reinforcement

Award Number: R01DA038168
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract: Motivated behaviors such as feeding and reward-seeking are critical for an organism's survival. These processes require distributed neuronal networks and supporting cell types in multiple brain regions to be tightly regulated and tuned in order to orchestrate behavioral output. The lateral hypothalamic area (LHA) has long been identified as a critical neuroanatomical substrate for motivated behavior. Despite decades of research, the molecular identity of defined LHA cell types remains poorly understood. Additionally, while LHA neurons have been previously shown to encode appetitive and consummatory behaviors via distinct cellular ensembles, it remains unknown how distinct LHA output neurons contribute to these processes. Here we propose to continue to study the neural circuits of the LHA, and to identify how distinct cell types contribute to feeding and reinforcement. Using an interdisciplinary approach to leverage cutting edge tools such as single cell transcriptional profiling, two photon calcium imaging, and viral we aim to undercover key circuit elements, and novel circuit specific gene expression patterns that can be leveraged for future therapeutic interventions for addiction and other neuropsychiatric disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $430,038 )
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	000	10	3/5/2024	NON-COMPETING CONTINUATION	$387,035
2024	2024	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	001	10	4/24/2024	NON-COMPETING CONTINUATION	$43,003
														Subtotal = $430,038

Issue Date FY: 2023 ( Subtotal = $458,114 )
2023	2023	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	000	9	3/1/2023	NON-COMPETING CONTINUATION	$458,114
														Subtotal = $458,114

Issue Date FY: 2022 ( Subtotal = $408,836 )
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	001	8	3/18/2022	NON-COMPETING CONTINUATION	$40,885
2022	2022	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	000	8	3/8/2022	NON-COMPETING CONTINUATION	$367,951
														Subtotal = $408,836

Issue Date FY: 2021 ( Subtotal = $439,595 )
2021	2021	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	001	7	4/23/2021	COMPETING CONTINUATION	$439,595
2021	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	000	6	2/1/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $439,595

Issue Date FY: 2019 ( Subtotal = $21,634 )
2019	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	001	6	4/9/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$359,817
2019	2018	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Drug Abuse and Addiction Research Programs	003	6	7/29/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$49,369
2019	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Abuse and Addiction Research Programs	000	5	4/9/2019	NON-COMPETING CONTINUATION	-$338,183
2019	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Abuse and Addiction Research Programs	002	4	7/29/2019	NON-COMPETING CONTINUATION	-$49,369
														Subtotal = $21,634

Issue Date FY: 2018 ( Subtotal = $338,183 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Abuse and Addiction Research Programs	000	5	6/27/2018	NON-COMPETING CONTINUATION	$338,183
														Subtotal = $338,183

Issue Date FY: 2017 ( Subtotal = $338,183 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Abuse and Addiction Research Programs	000	4	6/29/2017	NON-COMPETING CONTINUATION	$338,183
														Subtotal = $338,183

Issue Date FY: 2016 ( Subtotal = $407,818 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Abuse and Addiction Research Programs	000	3	7/28/2016	NON-COMPETING CONTINUATION	$407,818
														Subtotal = $407,818

Issue Date FY: 2015 ( Subtotal = $406,866 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Abuse and Addiction Research Programs	000	2	6/30/2015	NON-COMPETING CONTINUATION	$333,110
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Abuse and Addiction Research Programs	001	2	7/13/2015	SUPPLEMENT FOR EXPANSION	$73,756
														Subtotal = $406,866

Issue Date FY: 2014 ( Subtotal = $295,200 )
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Drug Abuse and Addiction Research Programs	000	1	6/10/2014	NEW	$295,200
														Subtotal = $295,200

Grand Total All Awards = $3,544,467

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Lateral Hypothalamic Circuits for Feeding and Reinforcement

Award Number: R01DA038168

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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