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Incentive salience and the neuropsychological underpinnings of cue-induced smoking relapse

Award Number: R01DA032581
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2012
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Incentive salience and the neuropsychological underpinnings of cue-induced smoking relapse - PROJECT SUMMARY Progress in basic neuroscience has improved our understanding of addiction neurobiology, but what has proven difficult is translating this knowledge into effective relapse prevention treatments. Identifying the neurobiological mechanisms underlying relapse will likely promote the development of better targeted therapeutic interventions to prevent it. In our previous funding cycle, we showed that smokers with larger brain responses to cigarette- related cues than pleasant stimuli are more vulnerable to relapse than smokers with the opposite brain reactivity profile. The objective of this renewal is to identify the neuropsychological mechanisms underlying these brain reactivity profiles and determine how these mechanisms affect vulnerability to cue-induced smoking relapse. Our central hypothesis is that the brain reactivity profiles that we isolated in smokers reflect individual differences in the tendency to attribute incentive salience to cues predicting rewards, a trait that increases vulnerability to cue- induced behaviors. Our hypothesis is based on the incentive sensitization theory and it is supported by preclinical findings and our own preliminary data. Animal models show that rats prone to attributing incentive salience to discrete food-related cues (called “sign-trackers”) are more vulnerable to cue-induced drug seeking behavior than rats not prone to do so (called “goal-trackers”). Our preliminary data show that the same neuropsychological trait predicts smoking relapse in smokers and cue-induced eating in the general population. We plan to test our hypothesis by pursuing two specific aims: 1) Identify the neuropsychological underpinnings of cue-induced behaviors. We will use the neurophysiological profiles derived from our newly developed cued food delivery task to classify 100 smokers and 100 nonsmokers as sign-trackers or goal-trackers, and predict cue-induced smoking and eating behaviors in the two groups. Our working hypotheses are that a) sign-trackers (both smokers and nonsmokers) will be more prone than goal-trackers to cue-induced eating and b) smokers categorized as sign-trackers in the cued food delivery task will be more prone than goal-trackers to cue-induced smoking in a laboratory model of smoking lapse behavior. 2) Determine the effects of nicotine withdrawal on cue-induced neurobehavioral responses. All participants will undergo two laboratory sessions. At session 2, smokers will be nicotine deprived for 24 hours. We hypothesize that nicotine deprivation will increase cue-induced smoking and eating behaviors in sign-trackers but not in goal-trackers. Our innovative neurobehavioral approach will advance bi-directional translation by allowing us to tie individual neurophysiological profiles to cue-induced be- haviors in humans. This project is significant because it will fundamentally advance our understanding of the mechanisms underlying impulse control disorders, the first step toward identifying new targets for personalized prevention and treatment interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	8	4/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $359,579 )
2024	2024	THE UNIVERISTY OF TEXAS MD ANDERSON CANCER CENTER, A COMPONENT OF THE UNIVERISTY OF TEXAS SYSTEM	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	8	4/23/2024	NON-COMPETING CONTINUATION	$359,579
														Subtotal = $359,579

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	7	3/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $359,579 )
2022	2022	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	7	4/27/2022	NON-COMPETING CONTINUATION	$359,579
														Subtotal = $359,579

Issue Date FY: 2021 ( Subtotal = $365,980 )
2021	2021	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	6	4/27/2021	NON-COMPETING CONTINUATION	$365,980
														Subtotal = $365,980

Issue Date FY: 2020 ( Subtotal = $366,677 )
2020	2020	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	5	7/9/2020	COMPETING CONTINUATION	$366,677
														Subtotal = $366,677

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2014	UNIVERSITY OF OKLAHOMA	865 RESEARCH PKWY STE 530	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	000	4	12/1/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = -$200,000 )
2017	2014	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	001	4	1/4/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$228,933
2017	2014	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	006	4	6/19/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$28,933
2017	2014	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	005	3	6/19/2017	NON-COMPETING CONTINUATION	-$28,933
2017	2014	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	002	3	3/23/2017	NON-COMPETING CONTINUATION	$228,933
2017	2014	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	004	3	3/24/2017	NON-COMPETING CONTINUATION	-$200,000
2017	2014	UNIVERSITY OF OKLAHOMA	1100 N LINDSAY SCB 219	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Drug Use and Addiction Research Programs	003	4	3/23/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$228,933
2017	2014	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	3	1/4/2017	NON-COMPETING CONTINUATION	-$228,933
														Subtotal = -$200,000

Issue Date FY: 2016 ( Subtotal = $200,000 )
2016	2014	UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER	POST OFFICE BOX 26901	OKLAHOMA CITY	OK	73126	OKLAHOMA	USA	Drug Use and Addiction Research Programs	000	4	6/2/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$200,000
														Subtotal = $200,000

Issue Date FY: 2014 ( Subtotal = $337,725 )
2014	2014	UNIV OF TEXAS SYS CANCER CTR, M D ANDERSON HOSP/TUM INS	1515 HOLCOMBE BLVD, ROOM 202	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	3	6/11/2014	NON-COMPETING CONTINUATION	$337,725
														Subtotal = $337,725

Issue Date FY: 2013 ( Subtotal = $324,216 )
2013	2013	UNIV OF TEXAS SYS CANCER CTR, M D ANDERSON HOSP/TUM INS	1515 HOLCOMBE BLVD, ROOM 202	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	2	6/12/2013	NON-COMPETING CONTINUATION	$324,216
														Subtotal = $324,216

Issue Date FY: 2012 ( Subtotal = $337,725 )
2012	2012	UNIV OF TEXAS SYS CANCER CTR, M D ANDERSON HOSP/TUM INS	1515 HOLCOMBE BLVD, ROOM 202	HOUSTON	TX	77030	HARRIS	USA	Drug Use and Addiction Research Programs	000	1	7/6/2012	NEW	$337,725
														Subtotal = $337,725

Grand Total All Awards = $2,451,481

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Incentive salience and the neuropsychological underpinnings of cue-induced smoking relapse

Award Number: R01DA032581

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2012

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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